Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
Found 59 products of "Gamma-secretase"
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CB-103
CAS:<p>CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.</p>Formula:C15H18N2OPurity:99.44%Color and Shape:SolidMolecular weight:242.32Demcizumab
CAS:<p>Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.</p>Purity:> 95%Color and Shape:LiquidMolecular weight:145.34 kDaBrontictuzumab
CAS:<p>Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.</p>Purity:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Color and Shape:LiquidRovalpituzumab
CAS:<p>Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.</p>Purity:> 95%Color and Shape:LiquidMolecular weight:145.02 kDaBMS-906024
CAS:<p>BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.</p>Formula:C26H26F6N4O3Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:556.5Navicixizumab
CAS:<p>Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.</p>Color and Shape:LiquidSPL-707
CAS:<p>SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).</p>Formula:C27H28FN5O4Purity:98%Color and Shape:SolidMolecular weight:505.54γ-Secretase modulator 10
CAS:<p>γ-Secretase modulator 10 is a novel γ-secretase modulator.</p>Formula:C25H23F3N4O2Color and Shape:SolidMolecular weight:468.48CIA-1 (Free base)
CAS:<p>CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.</p>Formula:C17H19N3O2SPurity:99%Color and Shape:SolidMolecular weight:329.42RBPJ Inhibitor-1
CAS:<p>RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell</p>Formula:C17H14FN3O2Purity:99.58%Color and Shape:SoildMolecular weight:311.31Notch 1 TFA
<p>Notch 1 TFA encodes a member of the NOTCH family of proteins.</p>Formula:C64H98N15F3O25S3Purity:98%Color and Shape:SolidMolecular weight:1614.81SAHM1
CAS:<p>Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.</p>Formula:C94H162N36O23SPurity:98%Color and Shape:SolidMolecular weight:2196.58FRM-024
CAS:<p>FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment of</p>Formula:C22H22ClN5O2Color and Shape:SolidMolecular weight:423.9PSEN1-IN-2
<p>PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.</p>Formula:C20H18ClFN2O3SColor and Shape:SolidMolecular weight:420.885β-Cholanic acid
CAS:<p>5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.</p>Formula:C24H40O2Purity:98.91% - 99.89%Color and Shape:SoildMolecular weight:360.57PSEN1-IN-1
<p>PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50</p>Formula:C20H19ClF3NO3SColor and Shape:SolidMolecular weight:445.88Legumain inhibitor 1
CAS:<p>Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.</p>Formula:C23H25N5O4SPurity:98.14%Color and Shape:SolidMolecular weight:467.54Enoticumab
CAS:<p>Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.</p>Purity:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Color and Shape:Liquidγ-secretase modulator 3
CAS:<p>Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.</p>Formula:C24H23FN4OSPurity:98%Color and Shape:SolidMolecular weight:434.53IMR-1
CAS:<p>IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Formula:C15H15NO5S2Purity:97.96% - 98.38%Color and Shape:SolidMolecular weight:353.41LY900009
CAS:<p>LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.</p>Formula:C23H27N3O4Purity:97.07%Color and Shape:SolidMolecular weight:409.48JI130
CAS:<p>JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.</p>Formula:C23H24N2O3Purity:99.61%Color and Shape:SolidMolecular weight:376.45FLI-06
CAS:<p>FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).</p>Formula:C25H30N2O5Purity:99.81% - ≥98%Color and Shape:SolidMolecular weight:438.52γ-secretase modulator 1 hydrochloride
CAS:<p>gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].</p>Formula:C24H25ClN4OSPurity:98%Color and Shape:SolidMolecular weight:453IMR-1A
CAS:<p>IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Formula:C13H11NO5S2Purity:97.1% - 99.76%Color and Shape:SolidMolecular weight:325.36MK-0752 Sodium
CAS:<p>Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.</p>Formula:C21H21ClF2NaO4SColor and Shape:SolidMolecular weight:465.89RO7185876
CAS:<p>RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.</p>Formula:C25H28F3N7Purity:99.50%Color and Shape:SolidMolecular weight:483.532Dilpacimab
CAS:<p>Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.</p>Purity:95% - 95%Color and Shape:LiquidTarlatamab
CAS:<p>"Tarlatamab (AMG-757), a BiTE antibody, targets DLL3, prevalent in SCLC tumors with scant normal tissue expression, and shows promise for SCLC research."</p>Color and Shape:LiquidTarextumab
CAS:<p>Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.</p>Purity:95%Color and Shape:Liquidγ-secretase modulator 1
CAS:<p>gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.</p>Formula:C24H24N4OSPurity:99.75% - 99.96%Color and Shape:SolidMolecular weight:416.54JI051
CAS:<p>JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.</p>Formula:C22H24N2O3Purity:≥98% - ≥98.0%Color and Shape:SolidMolecular weight:364.44BPN-15606
CAS:<p>BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.</p>Formula:C23H23FN6OColor and Shape:SolidMolecular weight:418.47Yhhu-3792
CAS:<p>Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.</p>Formula:C24H24N4O2Color and Shape:SolidMolecular weight:400.47ELN318463 racemate
CAS:<p>ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.</p>Formula:C19H20BrClN2O3SPurity:99.69%Color and Shape:SolidMolecular weight:471.8γ-secretase modulator 2
CAS:<p>Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.</p>Formula:C25H22F4N6O2Purity:98%Color and Shape:SolidMolecular weight:514.47Aβ42-IN-2
CAS:<p>Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].</p>Formula:C24H26N6O2Purity:98.09% - 99.87%Color and Shape:SolidMolecular weight:430.5ELN318463
CAS:<p>ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.</p>Formula:C19H20BrClN2O3SPurity:98%Color and Shape:SolidMolecular weight:471.8CIA-1 hcl(452087-38-6 Free base)
CAS:<p>CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of</p>Formula:C17H20ClN3O2SPurity:99.02%Color and Shape:SolidMolecular weight:365.88γ-Secretase modulator 4
CAS:<p>γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.</p>Formula:C23H19FN4O2Purity:98%Color and Shape:SolidMolecular weight:402.42tCFA15
CAS:<p>tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.</p>Formula:C24H44O2Purity:98%Color and Shape:SolidMolecular weight:364.61RR-11a analog
CAS:<p>RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).</p>Formula:C22H29N5O8Purity:98.80%Color and Shape:SolidMolecular weight:491.49γ-Secretase modulator 11
CAS:<p>5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and</p>Formula:C28H22F2N4O2Color and Shape:SolidMolecular weight:484.5LY-411575 isomer 1
CAS:<p>LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.</p>Formula:C26H23F2N3O4Purity:98%Color and Shape:SolidMolecular weight:479.48Aβ42-IN-1 free base
CAS:<p>Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091</p>Formula:C29H26N4O2Purity:98%Color and Shape:SolidMolecular weight:462.54RR-11a
CAS:<p>RR-11a is a synthetic enzyme Legumain inhibitor.</p>Formula:C24H28N6O10Purity:98%Color and Shape:SolidMolecular weight:560.51BMS-983970
CAS:<p>BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.</p>Formula:C26H26F4N4O3Color and Shape:SolidMolecular weight:518.5BT-GSI
<p>BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.</p>Formula:C26H46BrN5O10P2Color and Shape:SolidMolecular weight:730.52Yhhu-3792 hydrochloride
CAS:<p>Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].</p>Formula:C24H25ClN4O2Color and Shape:SolidMolecular weight:436.93BMS-932481
CAS:<p>BMS-932481 is a γ-secretase modulator.</p>Formula:C24H24FN7OColor and Shape:SolidMolecular weight:445.49GSM-1
CAS:<p>GSM-1 is a modulator of γ-Secretase.</p>Formula:C26H31ClF3NO2Color and Shape:SolidMolecular weight:481.98Gossypolone
CAS:<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Formula:C30H26O10Purity:96.66%Color and Shape:SolidMolecular weight:546.52γ-Secretase modulator 11 hydrochloride
CAS:<p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>Formula:C28H23ClF2N4O2Color and Shape:SolidMolecular weight:520.96PF-06648671
CAS:<p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>Formula:C25H23ClF4N4O3Purity:98%Color and Shape:SolidMolecular weight:538.92DAPM
CAS:<p>DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.</p>Formula:C20H20F2N2O4Purity:99.76%Color and Shape:SolidMolecular weight:390.38BPN-15606 besylate
<p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>Formula:C29H29FN6O4SColor and Shape:SolidMolecular weight:576.64Notch inhibitor 1
CAS:<p>Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.</p>Formula:C26H25F7N4O3Purity:98%Color and Shape:SolidMolecular weight:574.49Aβ42-IN-1
CAS:<p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formula:C29H27ClN4O2Purity:98%Color and Shape:SolidMolecular weight:499HDAC6-IN-9
CAS:<p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>Formula:C19H16N2O3Purity:98.84%Color and Shape:SolidMolecular weight:320.34
