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Gamma-secretase

Gamma-secretase

Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.

Found 59 products of "Gamma-secretase"

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  • GSM-1
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    GSM-1

    CAS:
    <p>GSM-1 is a modulator of γ-Secretase.</p>
    Formula:C26H31ClF3NO2
    Color and Shape:Solid
    Molecular weight:481.98

    Ref: TM-T24116

  • Gossypolone
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    Gossypolone

    CAS:
    <p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>
    Formula:C30H26O10
    Purity:96.66%
    Color and Shape:Solid
    Molecular weight:546.52

    Ref: TM-T31987

  • γ-Secretase modulator 11 hydrochloride
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    γ-Secretase modulator 11 hydrochloride

    CAS:
    <p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>
    Formula:C28H23ClF2N4O2
    Color and Shape:Solid
    Molecular weight:520.96

    Ref: TM-T63638

  • PF-06648671
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    PF-06648671

    CAS:
    <p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>
    Formula:C25H23ClF4N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.92

    Ref: TM-T24621

  • DAPM
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    DAPM

    CAS:
    <p>DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.</p>
    Formula:C20H20F2N2O4
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:390.38

    Ref: TM-T86161

  • CymitQuimica logo
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    BPN-15606 besylate

    <p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>
    Formula:C29H29FN6O4S
    Color and Shape:Solid
    Molecular weight:576.64

    Ref: TM-T64081

  • Notch inhibitor 1
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    Notch inhibitor 1

    CAS:
    <p>Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.</p>
    Formula:C26H25F7N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:574.49

    Ref: TM-T16341

  • Aβ42-IN-1
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    Aβ42-IN-1

    CAS:
    <p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>
    Formula:C29H27ClN4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:499

    Ref: TM-T10211

  • HDAC6-IN-9
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    HDAC6-IN-9

    CAS:
    <p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>
    Formula:C19H16N2O3
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:320.34

    Ref: TM-T60856