Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
Found 62 products of "Gamma-secretase"
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BMS-932481
CAS:BMS-932481 is a γ-secretase modulator.Formula:C24H24FN7OColor and Shape:SolidMolecular weight:445.49Yhhu-3792 hydrochloride
CAS:Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].Formula:C24H25ClN4O2Color and Shape:SolidMolecular weight:436.93GSM-1
CAS:GSM-1 is a modulator of γ-Secretase.Formula:C26H31ClF3NO2Color and Shape:SolidMolecular weight:481.98BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Formula:C26H26F4N4O3Color and Shape:SolidMolecular weight:518.5HDAC6-IN-9
CAS:HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.Formula:C19H16N2O3Purity:98.84%Color and Shape:SolidMolecular weight:320.34γ-Secretase modulator 11 hydrochloride
CAS:<p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>Formula:C28H23ClF2N4O2Color and Shape:SolidMolecular weight:520.96DAPM
CAS:DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Formula:C20H20F2N2O4Purity:99.76%Color and Shape:SolidMolecular weight:390.38PF-06442609
CAS:PF-06442609 is an orally active γ-secretase modulator with an IC50 value of 6 nM for Aβ42. It exhibits good CNS permeability.Formula:C24H24F4N4O3Molecular weight:492.47BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Formula:C29H29FN6O4SColor and Shape:SolidMolecular weight:576.64PF-06648671
CAS:PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.Formula:C25H23ClF4N4O3Purity:98%Color and Shape:SolidMolecular weight:538.92Notch inhibitor 1
CAS:Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.Formula:C26H25F7N4O3Purity:98%Color and Shape:SolidMolecular weight:574.49Aβ42-IN-1
CAS:Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).Formula:C29H27ClN4O2Purity:98%Color and Shape:SolidMolecular weight:499
