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Aurora Kinase

Aurora Kinase

Aurora kinase inhibitors target the Aurora kinases, a family of serine/threonine kinases that play a critical role in the regulation of mitosis. These kinases are essential for proper chromosome alignment, segregation, and cytokinesis during cell division. Abnormal Aurora kinase activity can lead to uncontrolled cell proliferation and cancer. By inhibiting Aurora kinases, these compounds can induce cell cycle arrest and apoptosis in cancer cells, making them valuable tools in cancer research and therapy. At CymitQuimica, we offer a wide range of high-quality Aurora kinase inhibitors to support your research in cell cycle regulation, mitosis, and oncology.

Found 94 products of "Aurora Kinase"

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  • VE-465
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    VE-465

    CAS:
    <p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>
    Formula:C22H28N8OS
    Color and Shape:Solid
    Molecular weight:452.58

    Ref: TM-T29101

  • RET-IN-19
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    RET-IN-19

    CAS:
    <p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>
    Formula:C28H28N6O4S
    Color and Shape:Solid
    Molecular weight:544.62

    Ref: TM-T63837

  • BI-831266
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    BI-831266

    CAS:
    <p>BI-831266 is a potent and selective Aurora kinase B inhibitor.</p>
    Formula:C27H38ClN7O2
    Color and Shape:Solid
    Molecular weight:528.09

    Ref: TM-T68234

  • Aurora kinase inhibitor-9
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    Aurora kinase inhibitor-9

    CAS:
    <p>Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.</p>
    Formula:C19H17Cl2N3O4S
    Color and Shape:Solid
    Molecular weight:454.33

    Ref: TM-T62789

  • Aurora kinase inhibitor-10
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    Aurora kinase inhibitor-10

    CAS:
    <p>Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.</p>
    Formula:C21H19F5N6O4S
    Color and Shape:Solid
    Molecular weight:546.47

    Ref: TM-T63853

  • L 888607 Racemate
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    L 888607 Racemate

    CAS:
    <p>L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.</p>
    Formula:C19H15ClFNO2S
    Color and Shape:Solid
    Molecular weight:375.84

    Ref: TM-T15829

  • Ilorasertib hydrochloride
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    Ilorasertib hydrochloride

    CAS:
    <p>Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:</p>
    Formula:C25H22ClFN6O2S
    Purity:98.45%
    Color and Shape:Solid
    Molecular weight:525

    Ref: TM-T11638

  • Binucleine 2
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    Binucleine 2

    CAS:
    <p>Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.</p>
    Formula:C13H11ClFN5
    Color and Shape:Solid
    Molecular weight:291.71

    Ref: TM-T36801

  • FAK/aurora kinase-IN-1
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    FAK/aurora kinase-IN-1

    CAS:
    <p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>
    Formula:C23H24ClN7O3
    Color and Shape:Solid
    Molecular weight:481.93

    Ref: TM-T86400

  • Tripolin A
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    Tripolin A

    CAS:
    <p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>
    Formula:C15H11NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:253.25

    Ref: TM-T8537

  • Aurora Kinases-IN-2
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    Aurora Kinases-IN-2

    CAS:
    <p>Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.</p>
    Formula:C22H18ClN5O3
    Color and Shape:Solid
    Molecular weight:435.86

    Ref: TM-T62484

  • Aurora A/PKC-IN-1
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    Aurora A/PKC-IN-1

    CAS:
    <p>Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.</p>
    Formula:C16H14N6OSe2
    Color and Shape:Solid
    Molecular weight:464.24

    Ref: TM-T62945

  • OM-137
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    OM-137

    CAS:
    <p>OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.</p>
    Formula:C13H14N4O3S
    Color and Shape:Solid
    Molecular weight:306.34

    Ref: TM-T71875

  • GRK6-IN-1
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    GRK6-IN-1

    CAS:
    <p>GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.</p>
    Formula:C22H23ClN6O2
    Purity:99.37%
    Color and Shape:Solid
    Molecular weight:438.91

    Ref: TM-T62518

  • CD532
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    CD532

    CAS:
    <p>CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.</p>
    Formula:C26H25F3N8O
    Purity:99.49%
    Color and Shape:Solid
    Molecular weight:522.52

    Ref: TM-T50110

  • Chiauranib
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    Chiauranib

    CAS:
    <p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>
    Formula:C27H21N3O3
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:435.47

    Ref: TM-T35570

  • Aurora kinase inhibitor-8
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    Aurora kinase inhibitor-8

    CAS:
    <p>Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.</p>
    Formula:C30H29N7O3
    Color and Shape:Solid
    Molecular weight:535.6

    Ref: TM-T63773

  • AAPK-25
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    AAPK-25

    CAS:
    <p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>
    Formula:C21H13Cl2N3O2S
    Purity:97.05%
    Color and Shape:Solid
    Molecular weight:442.32

    Ref: TM-T10215

  • GSK2646264
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    GSK2646264

    CAS:
    <p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>
    Formula:C24H26N2O2
    Color and Shape:Solid
    Molecular weight:374.48

    Ref: TM-T61527

  • Aurora Kinases-IN-4
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    Aurora Kinases-IN-4

    CAS:
    <p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>
    Formula:C26H28N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:468.55

    Ref: TM-T78753