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Aurora Kinase

Aurora Kinase

Aurora kinase inhibitors target the Aurora kinases, a family of serine/threonine kinases that play a critical role in the regulation of mitosis. These kinases are essential for proper chromosome alignment, segregation, and cytokinesis during cell division. Abnormal Aurora kinase activity can lead to uncontrolled cell proliferation and cancer. By inhibiting Aurora kinases, these compounds can induce cell cycle arrest and apoptosis in cancer cells, making them valuable tools in cancer research and therapy. At CymitQuimica, we offer a wide range of high-quality Aurora kinase inhibitors to support your research in cell cycle regulation, mitosis, and oncology.

Found 111 products of "Aurora Kinase"

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  • Aurora B inhibitor 1
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    Aurora B inhibitor 1

    CAS:
    Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.
    Formula:C25H26ClF2N7O2
    Purity:98.37%
    Color and Shape:Solid
    Molecular weight:529.97

    Ref: TM-T12010

  • Aurora A inhibitor 1
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    Aurora A inhibitor 1

    CAS:
    Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)
    Formula:C25H28ClF2N5O2
    Color and Shape:Solid
    Molecular weight:503.97

    Ref: TM-T63436

  • Aurora inhibitor 1
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    Aurora inhibitor 1

    CAS:
    Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).
    Formula:C23H25N9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.57

    Ref: TM-T10412

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    Hesperadin hydrochloride

    Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.
    Formula:C29H33ClN4O3S
    Color and Shape:Solid
    Molecular weight:553.12

    Ref: TM-T63905

  • SCH-1473759
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    SCH-1473759

    CAS:
    SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).
    Formula:C20H26N8OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:426.54

    Ref: TM-T16862

  • 6K465
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    6K465

    CAS:
    6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.
    Formula:C26H33ClFN9O
    Purity:99.78%
    Color and Shape:Solid
    Molecular weight:542.05

    Ref: TM-T85508

  • BET/Aurora kinase-IN-1
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    BET/Aurora kinase-IN-1

    CAS:
    BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.
    Formula:C25H30FN7O
    Color and Shape:Solid
    Molecular weight:463.55

    Ref: TM-T205073

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    Aurora A inhibitor 4

    CAS:
    Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.
    Formula:C22H23N5O3
    Molecular weight:405.45

    Ref: TM-T204214

  • BRD-7880
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    BRD-7880

    CAS:
    BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.
    Formula:C32H38N4O7
    Color and Shape:Solid
    Molecular weight:590.67

    Ref: TM-T70600

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    Aurora/LIM kinase-IN-1

    Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.
    Formula:C16H20N6O
    Color and Shape:Solid
    Molecular weight:312.37

    Ref: TM-T60783

  • PF-03814735
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    PF-03814735

    CAS:
    PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
    Formula:C23H25F3N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.48

    Ref: TM-T6936

    1mg
    Discontinued
    Discontinued product