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DNA/RNA Synthesis

DNA/RNA Synthesis

Inhibitors of DNA and RNA synthesis are compounds that interfere with the replication and transcription processes in cells, thereby preventing the production of essential genetic material. These inhibitors can target various enzymes and proteins involved in nucleic acid synthesis, making them valuable tools for studying the mechanisms of replication, transcription, and translation. They are also used in developing treatments for infections and cancer. At CymitQuimica, we offer a broad spectrum of DNA/RNA synthesis inhibitors to support your research in molecular biology, virology, and therapeutic development.

Found 763 products of "DNA/RNA Synthesis"

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  • RNase L ligand 3
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    RNase L ligand 3

    CAS:
    RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.
    Formula:C27H27N3OS
    Color and Shape:Solid
    Molecular weight:441.59

    Ref: TM-T210787

  • 6-N-Hydroxylaminopurine
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    6-N-Hydroxylaminopurine

    CAS:
    6-N-Hydroxylaminopurine is a base analog with mutagenic activity.
    Formula:C5H5N5O
    Molecular weight:151.13

    Ref: TM-T210412

  • Deoxythymidine-5'-triphosphate-d15
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    Deoxythymidine-5'-triphosphate-d15

    CAS:
    Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.
    Formula:C10H15Li2N2O14P3
    Color and Shape:Solid
    Molecular weight:509.13

    Ref: TM-T211806

  • Eprociclovir Na
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    Eprociclovir Na

    CAS:
    Eprociclovir Na (A-5021) is 15x stronger than acyclovir at inhibiting herpesviruses, showing promise for EHV1 and herpetic keratitis treatment.
    Formula:C11H14N5NaO3
    Color and Shape:Solid
    Molecular weight:287.25

    Ref: TM-T69817

  • DIDS
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    DIDS

    CAS:
    <p>DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.</p>
    Formula:C16H10N2O6S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:454.52

    Ref: TM-T20694

  • Methyl 3-oxodecanoate
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    Methyl 3-oxodecanoate

    CAS:
    <p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>
    Formula:C11H20O3
    Color and Shape:Solid
    Molecular weight:200.275

    Ref: TM-T206384

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    CYP2C19-IN-1

    <p>CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.</p>
    Formula:C26H26N2O6S
    Color and Shape:Solid
    Molecular weight:494.56

    Ref: TM-T63337

  • DNA polymerase-IN-6
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    DNA polymerase-IN-6

    CAS:
    DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.
    Formula:C26H28ClFN8O4
    Color and Shape:Solid
    Molecular weight:571.003

    Ref: TM-T204284

  • Antimalarial agent 44
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    Antimalarial agent 44

    Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.
    Formula:C37H37N5O7
    Color and Shape:Solid
    Molecular weight:663.72

    Ref: TM-T201453

  • WRN inhibitor 13
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    WRN inhibitor 13

    CAS:
    WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.
    Formula:C16H20N2O5S
    Color and Shape:Solid
    Molecular weight:352.405

    Ref: TM-T204389

  • Metesind Glucuronate
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    Metesind Glucuronate

    CAS:
    <p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>
    Formula:C29H34N4O10S
    Color and Shape:Solid
    Molecular weight:630.67

    Ref: TM-T24454

  • NSC 641396
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    NSC 641396

    CAS:
    NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.
    Formula:C18H13NO3
    Color and Shape:Solid
    Molecular weight:291.301

    Ref: TM-T204449

  • KWR095
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    KWR095

    CAS:
    <p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>
    Formula:C33H31ClF3N9O4
    Color and Shape:Solid
    Molecular weight:710.105

    Ref: TM-T205595

  • TREX1-IN-3
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    TREX1-IN-3

    CAS:
    <p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Color and Shape:Solid
    Molecular weight:490.898

    Ref: TM-T205254

  • HPH-15
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    HPH-15

    CAS:
    <p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>
    Formula:C19H31N3S4
    Color and Shape:Solid
    Molecular weight:429.73

    Ref: TM-T205327

  • PCNA-IN-1
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    PCNA-IN-1

    CAS:
    <p>PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.</p>
    Formula:C19H18I3NO3
    Color and Shape:Solid
    Molecular weight:689.065

    Ref: TM-T204170

  • TREX1-IN-4
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    TREX1-IN-4

    CAS:
    <p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Color and Shape:Solid
    Molecular weight:490.898

    Ref: TM-T205208

  • NRTT-IN-1
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    NRTT-IN-1

    CAS:
    <p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>
    Formula:C28H24FN5O5
    Color and Shape:Solid
    Molecular weight:529.519

    Ref: TM-T205482

  • 2-CEES
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    2-CEES

    CAS:
    <p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>
    Formula:C4H9ClS
    Color and Shape:Solid
    Molecular weight:124.632

    Ref: TM-T204286

  • MTH1 activator-1
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    MTH1 activator-1

    CAS:
    MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.
    Formula:C29H23F3N4O2
    Color and Shape:Solid
    Molecular weight:516.514

    Ref: TM-T204503

  • WRN inhibitor 11
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    WRN inhibitor 11

    CAS:
    WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.
    Formula:C34H35ClF3N9O5
    Color and Shape:Solid
    Molecular weight:742.15

    Ref: TM-T201262

  • Polθ-IN-6
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    Polθ-IN-6

    CAS:
    Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.
    Formula:C25H23N3O3S
    Color and Shape:Solid
    Molecular weight:445.53

    Ref: TM-T200918

  • WRN inhibitor 12
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    WRN inhibitor 12

    CAS:
    WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.
    Formula:C33H33ClF3N9O5
    Color and Shape:Solid
    Molecular weight:728.12

    Ref: TM-T201316

  • Polθ-IN-5
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    Polθ-IN-5

    CAS:
    <p>Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.</p>
    Formula:C23H18ClF2N7O3S
    Color and Shape:Solid
    Molecular weight:545.95

    Ref: TM-T200913

  • 12(S)-HETE
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    12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Formula:C20H32O3
    Color and Shape:Solid
    Molecular weight:320.47

    Ref: TM-T37047

  • PolQi1
    Targetmol
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    PolQi1

    CAS:
    <p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>
    Formula:C18H14ClF5N4O2
    Purity:98.97%
    Color and Shape:Solid
    Molecular weight:448.77

    Ref: TM-T89335

  • Werner syndrome RecQ helicase-IN-2
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    Werner syndrome RecQ helicase-IN-2

    CAS:
    Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.
    Formula:C32H34F3N9O5
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:681.67

    Ref: TM-T72108

  • 5-Fluorouridine 5'-phosphate
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    5-Fluorouridine 5'-phosphate

    CAS:
    <p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>
    Formula:C9H12FN2O9P
    Color and Shape:Solid
    Molecular weight:342.172

    Ref: TM-T205644

  • ATIC-IN-2
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    ATIC-IN-2

    CAS:
    <p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>
    Formula:C4H4N4O3S
    Color and Shape:Solid
    Molecular weight:188.165

    Ref: TM-T204433

  • Bersiporocin
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    Bersiporocin

    CAS:
    <p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>
    Formula:C15H19Cl2N3O
    Purity:98.88% - 99.79%
    Color and Shape:Solid
    Molecular weight:328.24

    Ref: TM-T39739

  • CymitQuimica logo
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    Antitumor agent-74

    Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.
    Formula:C26H23FN6
    Color and Shape:Solid
    Molecular weight:438.5

    Ref: TM-T62509

  • CymitQuimica logo
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    4,5'-Dimethylangelicin-NHS

    NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.
    Formula:C21H19NO7S
    Color and Shape:Solid
    Molecular weight:429.44

    Ref: TM-T62365

  • BAY-364
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    BAY-364

    CAS:
    BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+
    Formula:C23H19N3O4
    Color and Shape:Solid
    Molecular weight:401.41

    Ref: TM-T73451

  • D-G23
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    D-G23

    CAS:
    <p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>
    Formula:C19H22N4O3
    Color and Shape:Solid
    Molecular weight:354.403

    Ref: TM-T206763

  • APE1-IN-3
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    APE1-IN-3

    CAS:
    <p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>
    Formula:C17H16O4
    Color and Shape:Solid
    Molecular weight:284.31

    Ref: TM-T89919

  • Adafosbuvir
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    Adafosbuvir

    CAS:
    <p>Adafosbuvir has antiviral activity.</p>
    Formula:C22H29FN3O10P
    Color and Shape:Solid
    Molecular weight:545.457

    Ref: TM-T26560

  • L-2'-Fd4C
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    L-2'-Fd4C

    CAS:
    L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].
    Formula:C9H10FN3O3
    Color and Shape:Solid
    Molecular weight:227.19

    Ref: TM-T60285

  • CymitQuimica logo
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    Pol I-IN-1

    Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition
    Formula:C23H22N4O2
    Color and Shape:Solid
    Molecular weight:386.45

    Ref: TM-T61720

  • CB 30900
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    CB 30900

    CAS:
    CB30900 is a novel and effective thymidylate synthase inhibitor.
    Formula:C31H32FN5O9
    Color and Shape:Solid
    Molecular weight:637.61

    Ref: TM-T30760

  • DENV-IN-6
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    DENV-IN-6

    CAS:
    <p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>
    Formula:C23H26ClFN4OS
    Color and Shape:Solid
    Molecular weight:461

    Ref: TM-T62908

  • RAD51-IN-6
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    RAD51-IN-6

    CAS:
    RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)
    Formula:C27H40N3O5PS
    Color and Shape:Solid
    Molecular weight:549.66

    Ref: TM-T63883

  • RAD51-IN-5
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    RAD51-IN-5

    CAS:
    <p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>
    Formula:C26H38N4O5S2
    Color and Shape:Solid
    Molecular weight:550.73

    Ref: TM-T63892

  • EFdA-TP tetrasodium
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    EFdA-TP tetrasodium

    CAS:
    EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.
    Formula:C12H11FN5Na4O12P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:621.12

    Ref: TM-T72461

  • CymitQuimica logo
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    ddCTP trisodium

    ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.
    Formula:C9H13N3Na3O12P3
    Color and Shape:Solid
    Molecular weight:517.1

    Ref: TM-T63602

  • GSK_WRN4
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    GSK_WRN4

    CAS:
    <p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>
    Formula:C16H20N2O4S
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:336.41

    Ref: TM-T200332

  • iPAF1C
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    iPAF1C

    CAS:
    <p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>
    Formula:C27H26BrFN4O
    Color and Shape:Solid
    Molecular weight:521.42

    Ref: TM-T86731

  • GTSE1-IN-1
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    GTSE1-IN-1

    CAS:
    <p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>
    Formula:C21H24FN7
    Color and Shape:Solid
    Molecular weight:393.46

    Ref: TM-T200127

  • Uridine 3',5'-diphosphate
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    Uridine 3',5'-diphosphate

    CAS:
    <p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>
    Formula:C9H14N2O12P2
    Color and Shape:Solid
    Molecular weight:404.16

    Ref: TM-T87599

  • 5-Iminodaunorubicin hydrochloride
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    5-Iminodaunorubicin hydrochloride

    CAS:
    <p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>
    Formula:C27H31ClN2O9
    Color and Shape:Solid
    Molecular weight:563.00

    Ref: TM-T72115

  • RAD51-IN-7
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    RAD51-IN-7

    CAS:
    RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)
    Formula:C25H31N5O4S2
    Color and Shape:Solid
    Molecular weight:529.67

    Ref: TM-T63728

  • DHX9-IN-9
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    DHX9-IN-9

    CAS:
    <p>DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].</p>
    Formula:C21H21ClFN5O3S2
    Color and Shape:Solid
    Molecular weight:510

    Ref: TM-T86205

  • T-2513 hydrochloride
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    T-2513 hydrochloride

    CAS:
    T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.
    Formula:C25H28ClN3O5
    Color and Shape:Solid
    Molecular weight:485.96

    Ref: TM-T63225

  • (Rac)-Plevitrexed
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    (Rac)-Plevitrexed

    CAS:
    (Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).
    Formula:C26H25FN8O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:532.53

    Ref: TM-T12674

  • GR 122222X
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    GR 122222X

    CAS:
    GR 122222X is an inhibitor of topoisomerase II.
    Formula:C26H35N5O11S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:625.65

    Ref: TM-T24100

  • Zorubicin
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    Zorubicin

    CAS:
    <p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>
    Formula:C34H35N3O10
    Color and Shape:Solid
    Molecular weight:645.66

    Ref: TM-T69130

  • CTPS1-IN-1
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    CTPS1-IN-1

    CAS:
    CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.
    Formula:C21H22N6O4S2
    Purity:99.46%
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T86105

  • HRO761
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    HRO761

    CAS:
    HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
    Formula:C31H31ClF3N9O5
    Purity:98.74% - 99.62%
    Color and Shape:Solid
    Molecular weight:702.08

    Ref: TM-T72107

  • SR 11302
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    SR 11302

    CAS:
    <p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>
    Formula:C26H32O2
    Purity:98.65%
    Color and Shape:Solid
    Molecular weight:376.53

    Ref: TM-T23384

  • NSC639828
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    NSC639828

    CAS:
    NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.
    Formula:C18H13BrClN5O3
    Color and Shape:Solid
    Molecular weight:462.69

    Ref: TM-T38742

    ne
    Discontinued
    Discontinued product
  • Ethynylcytidine
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    Ethynylcytidine

    CAS:
    <p>Ethynylcytidine is a nucleoside antimetabolite.</p>
    Formula:C11H13N3O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.24

    Ref: TM-TQ0006

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • 5'-DMT-3'-TBDMS-ibu-rG
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    5'-DMT-3'-TBDMS-ibu-rG

    CAS:
    <p>5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.</p>
    Formula:C41H51N5O8Si
    Color and Shape:Solid
    Molecular weight:769.96

    Ref: TM-T40919

    ne
    Discontinued
    Discontinued product
  • 5'-O-DMT-N6-ibu-dA
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    5'-O-DMT-N6-ibu-dA

    CAS:
    5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.
    Formula:C35H37N5O6
    Color and Shape:Solid
    Molecular weight:623.71

    Ref: TM-T39332

    ne
    Discontinued
    Discontinued product
  • MitoE10
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    MitoE10

    CAS:
    <p>MitoE10 is an effective mitochondrial targeting antioxidant.</p>
    Formula:C42H55O5PS
    Color and Shape:Solid
    Molecular weight:702.92

    Ref: TM-T33406

    25mg
    Discontinued
    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product