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DNA/RNA Synthesis

DNA/RNA Synthesis

Inhibitors of DNA and RNA synthesis are compounds that interfere with the replication and transcription processes in cells, thereby preventing the production of essential genetic material. These inhibitors can target various enzymes and proteins involved in nucleic acid synthesis, making them valuable tools for studying the mechanisms of replication, transcription, and translation. They are also used in developing treatments for infections and cancer. At CymitQuimica, we offer a broad spectrum of DNA/RNA synthesis inhibitors to support your research in molecular biology, virology, and therapeutic development.

Found 706 products of "DNA/RNA Synthesis"

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  • (R)-CSN5i-3
    Targetmol
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    (R)-CSN5i-3

    CAS:
    <p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>
    Formula:C28H29F2N5O2
    Purity:99.76% - 99.97%
    Color and Shape:Solid
    Molecular weight:505.56

    Ref: TM-T12620

  • DIDS
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    DIDS

    CAS:
    <p>DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.</p>
    Formula:C16H10N2O6S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:454.52

    Ref: TM-T20694

  • Epolactaene
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    Epolactaene

    CAS:
    <p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases &amp; human DNA topoisomerase II.</p>
    Formula:C21H27NO6
    Color and Shape:Solid
    Molecular weight:389.44

    Ref: TM-T70284

  • 5-Methylcytosine hydrochloride
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    5-Methylcytosine hydrochloride

    CAS:
    <p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>
    Formula:C5H8ClN3O
    Color and Shape:Solid
    Molecular weight:161.59

    Ref: TM-T201054

  • Antiviral agent 67
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    Antiviral agent 67

    CAS:
    <p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>
    Formula:C19H19N3O
    Color and Shape:Solid
    Molecular weight:305.374

    Ref: TM-T206310

  • DHX9-IN-19
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    DHX9-IN-19

    CAS:
    <p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>
    Formula:C20H21ClN4O4S2
    Color and Shape:Solid
    Molecular weight:480.988

    Ref: TM-T204732

  • L-2'-Fd4C
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    L-2'-Fd4C

    CAS:
    <p>L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].</p>
    Formula:C9H10FN3O3
    Color and Shape:Solid
    Molecular weight:227.19

    Ref: TM-T60285

  • Ladirubicin
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    Ladirubicin

    CAS:
    <p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>
    Formula:C29H31NO11S
    Color and Shape:Solid
    Molecular weight:601.62

    Ref: TM-T32534

  • CymitQuimica logo
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    Pol I-IN-1

    <p>Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition</p>
    Formula:C23H22N4O2
    Color and Shape:Solid
    Molecular weight:386.45

    Ref: TM-T61720

  • Polθ-IN-8
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    Polθ-IN-8

    CAS:
    <p>Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.</p>
    Formula:C22H22ClN7O3S
    Color and Shape:Solid
    Molecular weight:499.97

    Ref: TM-T207723

  • CB 30900
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    CB 30900

    CAS:
    <p>CB30900 is a novel and effective thymidylate synthase inhibitor.</p>
    Formula:C31H32FN5O9
    Color and Shape:Solid
    Molecular weight:637.61

    Ref: TM-T30760

  • DENV-IN-6
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    DENV-IN-6

    CAS:
    <p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>
    Formula:C23H26ClFN4OS
    Color and Shape:Solid
    Molecular weight:461

    Ref: TM-T62908

  • APE1-IN-3
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    APE1-IN-3

    CAS:
    <p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>
    Formula:C17H16O4
    Color and Shape:Solid
    Molecular weight:284.31

    Ref: TM-T89919

  • GTSE1-IN-1
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    GTSE1-IN-1

    CAS:
    <p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>
    Formula:C21H24FN7
    Color and Shape:Solid
    Molecular weight:393.46

    Ref: TM-T200127

  • WRN inhibitor 11
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    WRN inhibitor 11

    CAS:
    <p>WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.</p>
    Formula:C34H35ClF3N9O5
    Color and Shape:Solid
    Molecular weight:742.15

    Ref: TM-T201262

  • 2-CEES
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    2-CEES

    CAS:
    <p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>
    Formula:C4H9ClS
    Color and Shape:Solid
    Molecular weight:124.632

    Ref: TM-T204286

  • D-G23
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    D-G23

    CAS:
    <p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>
    Formula:C19H22N4O3
    Color and Shape:Solid
    Molecular weight:354.403

    Ref: TM-T206763

  • MTH1 activator-1
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    MTH1 activator-1

    CAS:
    <p>MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.</p>
    Formula:C29H23F3N4O2
    Color and Shape:Solid
    Molecular weight:516.514

    Ref: TM-T204503

  • NRTT-IN-1
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    NRTT-IN-1

    CAS:
    <p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>
    Formula:C28H24FN5O5
    Color and Shape:Solid
    Molecular weight:529.519

    Ref: TM-T205482

  • 12(S)-HETE
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    12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Formula:C20H32O3
    Color and Shape:Solid
    Molecular weight:320.47

    Ref: TM-T37047

  • Polθ-IN-5
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    Polθ-IN-5

    CAS:
    <p>Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.</p>
    Formula:C23H18ClF2N7O3S
    Color and Shape:Solid
    Molecular weight:545.95

    Ref: TM-T200913

  • Werner syndrome RecQ helicase-IN-2
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    Werner syndrome RecQ helicase-IN-2

    CAS:
    <p>Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.</p>
    Formula:C32H34F3N9O5
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:681.67

    Ref: TM-T72108

  • WRN inhibitor 12
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    WRN inhibitor 12

    CAS:
    <p>WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.</p>
    Formula:C33H33ClF3N9O5
    Color and Shape:Solid
    Molecular weight:728.12

    Ref: TM-T201316

  • Uridine 3',5'-diphosphate
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    Uridine 3',5'-diphosphate

    CAS:
    <p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>
    Formula:C9H14N2O12P2
    Color and Shape:Solid
    Molecular weight:404.16

    Ref: TM-T87599

  • Bersiporocin
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    Bersiporocin

    CAS:
    <p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>
    Formula:C15H19Cl2N3O
    Purity:98.88% - 99.79%
    Color and Shape:Solid
    Molecular weight:328.24

    Ref: TM-T39739

  • ATIC-IN-2
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    ATIC-IN-2

    CAS:
    <p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>
    Formula:C4H4N4O3S
    Color and Shape:Solid
    Molecular weight:188.165

    Ref: TM-T204433

  • Polθ-IN-6
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    Polθ-IN-6

    CAS:
    <p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>
    Formula:C25H23N3O3S
    Color and Shape:Solid
    Molecular weight:445.53

    Ref: TM-T200918

  • GSK_WRN4
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    GSK_WRN4

    CAS:
    <p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>
    Formula:C16H20N2O4S
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:336.41

    Ref: TM-T200332

  • AB25583
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    AB25583

    CAS:
    <p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>
    Formula:C22H17ClN4O3S
    Color and Shape:Solid
    Molecular weight:452.91

    Ref: TM-T200101

  • 2'-(2-Nitrobenzyl)-ATP
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    2'-(2-Nitrobenzyl)-ATP

    CAS:
    <p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>
    Formula:C17H21N6O15P3
    Color and Shape:Solid
    Molecular weight:642.30

    Ref: TM-T207643

  • RAD51-IN-6
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    RAD51-IN-6

    CAS:
    <p>RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)</p>
    Formula:C27H40N3O5PS
    Color and Shape:Solid
    Molecular weight:549.66

    Ref: TM-T63883

  • Polθ-IN-7
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    Polθ-IN-7

    CAS:
    <p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>
    Formula:C28H35F3N6O2
    Color and Shape:Solid
    Molecular weight:544.612

    Ref: TM-T204135

  • KL-50
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    KL-50

    CAS:
    <p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>
    Formula:C7H7FN6O2
    Color and Shape:Solid
    Molecular weight:226.17

    Ref: TM-T200136

  • N-Nitrosonornicotine
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    N-Nitrosonornicotine

    CAS:
    <p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>
    Formula:C9H11N3O
    Color and Shape:Solid
    Molecular weight:177.2

    Ref: TM-T201694

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS:
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Formula:C27H23N3O6
    Color and Shape:Solid
    Molecular weight:485.49

    Ref: TM-T87635

  • And1 degrader 1
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    And1 degrader 1

    CAS:
    <p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>
    Formula:C26H27Cl2N3O
    Color and Shape:Solid
    Molecular weight:468.42

    Ref: TM-T200443

  • LN-439A
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    LN-439A

    CAS:
    <p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>
    Formula:C24H26FN3O4
    Color and Shape:Solid
    Molecular weight:439.48

    Ref: TM-T200435

  • 2,5-Di-tert-butyl-1,4-benzoquinone
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    2,5-Di-tert-butyl-1,4-benzoquinone

    CAS:
    <p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>
    Formula:C14H20O2
    Color and Shape:Solid
    Molecular weight:220.31

    Ref: TM-T201504

  • Xanthosine-5'-Triphosphate trisodium
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    Xanthosine-5'-Triphosphate trisodium

    CAS:
    <p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>
    Formula:C10H12N4Na3O15P3
    Color and Shape:Solid
    Molecular weight:590.111

    Ref: TM-TXB-00592

  • RECTAS-2.0
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    RECTAS-2.0

    CAS:
    <p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G&gt;A mutation, intended for research in Fabry disease.</p>
    Formula:C18H17ClN4O4
    Color and Shape:Solid
    Molecular weight:388.805

    Ref: TM-T206725

  • GR 122222X
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    GR 122222X

    CAS:
    <p>GR 122222X is an inhibitor of topoisomerase II.</p>
    Formula:C26H35N5O11S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:625.65

    Ref: TM-T24100

  • GHP-88309
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    GHP-88309

    CAS:
    <p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>
    Formula:C16H11FN2O
    Color and Shape:Solid
    Molecular weight:266.27

    Ref: TM-T204819

  • VPC-80051
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    VPC-80051

    CAS:
    <p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>
    Formula:C16H13F2N3O
    Color and Shape:Solid
    Molecular weight:301.291

    Ref: TM-T204737

  • iPAF1C
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    iPAF1C

    CAS:
    <p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>
    Formula:C27H26BrFN4O
    Color and Shape:Solid
    Molecular weight:521.42

    Ref: TM-T86731

  • PolQi1
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    PolQi1

    CAS:
    <p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>
    Formula:C18H14ClF5N4O2
    Purity:98.97%
    Color and Shape:Solid
    Molecular weight:448.77

    Ref: TM-T89335

  • (Rac)-Plevitrexed
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    (Rac)-Plevitrexed

    CAS:
    <p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>
    Formula:C26H25FN8O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:532.53

    Ref: TM-T12674

  • 5-Fluorouridine 5'-phosphate
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    5-Fluorouridine 5'-phosphate

    CAS:
    <p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>
    Formula:C9H12FN2O9P
    Color and Shape:Solid
    Molecular weight:342.172

    Ref: TM-T205644

  • CTPS1-IN-1
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    CTPS1-IN-1

    CAS:
    <p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>
    Formula:C21H22N6O4S2
    Purity:99.46%
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T86105

  • HRO761
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    HRO761

    CAS:
    <p>HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.</p>
    Formula:C31H31ClF3N9O5
    Purity:98.74% - 99.62%
    Color and Shape:Solid
    Molecular weight:702.08

    Ref: TM-T72107

  • SR 11302
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    SR 11302

    CAS:
    <p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>
    Formula:C26H32O2
    Purity:98.65%
    Color and Shape:Solid
    Molecular weight:376.53

    Ref: TM-T23384