DNA/RNA Synthesis
Inhibitors of DNA and RNA synthesis are compounds that interfere with the replication and transcription processes in cells, thereby preventing the production of essential genetic material. These inhibitors can target various enzymes and proteins involved in nucleic acid synthesis, making them valuable tools for studying the mechanisms of replication, transcription, and translation. They are also used in developing treatments for infections and cancer. At CymitQuimica, we offer a broad spectrum of DNA/RNA synthesis inhibitors to support your research in molecular biology, virology, and therapeutic development.
Found 798 products of "DNA/RNA Synthesis"
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L-2'-Fd4C
CAS:L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].Formula:C9H10FN3O3Color and Shape:SolidMolecular weight:227.193'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite
CAS:3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite serves as a precursor of adenosine nucleotide monomers used in the solid-phase synthesis of oligonucleotides, particularly for modifying oligonucleotides such as terminally modified DNA strands. It features Trityl (Tr), Cyanoethyl (CE), and Dimethylformamidine (DMF) protective groups, classifying it as a ddNTP adenosine nucleoside suitable for applications like oligonucleotide solid-phase synthesis, probe design, and chain termination sequencing.Formula:C41H50N9O3PColor and Shape:SolidMolecular weight:747.87Pol I-IN-1
Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibitionFormula:C23H22N4O2Color and Shape:SolidMolecular weight:386.45CB 30900
CAS:CB30900 is a novel and effective thymidylate synthase inhibitor.Formula:C31H32FN5O9Color and Shape:SolidMolecular weight:637.61DENV-IN-6
CAS:DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.Formula:C23H26ClFN4OSColor and Shape:SolidMolecular weight:4613′-Amino-2′,3′-dideoxy-CTP
CAS:3′-Amino-2′,3′-dideoxy-CTP is an analog of nucleoside triphosphates. It selectively inhibits DNA polymerase β.Formula:C9H17N4O12P3Color and Shape:SolidMolecular weight:466.17GHP-88309
CAS:GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.Formula:C16H11FN2OColor and Shape:SolidMolecular weight:266.27VPC-80051
CAS:VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.Formula:C16H13F2N3OColor and Shape:SolidMolecular weight:301.291Xanthosine-5'-Triphosphate trisodium
CAS:Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).Formula:C10H12N4Na3O15P3Color and Shape:SolidMolecular weight:590.111RNase L ligand 3
CAS:RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.Formula:C27H27N3OSColor and Shape:SolidMolecular weight:441.59GTSE1-IN-1
CAS:GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Formula:C21H24FN7Color and Shape:SolidMolecular weight:393.466-N-Hydroxylaminopurine
CAS:6-N-Hydroxylaminopurine is a base analog with mutagenic activity.Formula:C5H5N5OMolecular weight:151.13Deoxythymidine-5'-triphosphate-d15
CAS:Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.Formula:C10H15Li2N2O14P3Color and Shape:SolidMolecular weight:509.13Eprociclovir Na
CAS:Eprociclovir Na (A-5021) is 15x stronger than acyclovir at inhibiting herpesviruses, showing promise for EHV1 and herpetic keratitis treatment.Formula:C11H14N5NaO3Color and Shape:SolidMolecular weight:287.25RAD51-IN-6
CAS:RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)Formula:C27H40N3O5PSColor and Shape:SolidMolecular weight:549.66RECTAS-2.0
CAS:RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.
Formula:C18H17ClN4O4Color and Shape:SolidMolecular weight:388.805BAY-364
CAS:BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+Formula:C23H19N3O4Color and Shape:SolidMolecular weight:401.41KL-50
CAS:KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.Formula:C7H7FN6O2Color and Shape:SolidMolecular weight:226.17Werner syndrome RecQ helicase-IN-2
CAS:Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formula:C32H34F3N9O5Purity:99.02%Color and Shape:SolidMolecular weight:681.67Antimalarial agent 44
Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.Formula:C37H37N5O7Color and Shape:SolidMolecular weight:663.72GR 122222X
CAS:GR 122222X is an inhibitor of topoisomerase II.Formula:C26H35N5O11SPurity:98%Color and Shape:SolidMolecular weight:625.65LN-439A
CAS:LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.Formula:C24H26FN3O4Color and Shape:SolidMolecular weight:439.48Polθ-IN-7
CAS:Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.Formula:C28H35F3N6O2Color and Shape:SolidMolecular weight:544.612DHX9-IN-19
CAS:DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.Formula:C20H21ClN4O4S2Color and Shape:SolidMolecular weight:480.988Antitumor agent-74
Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.Formula:C26H23FN6Color and Shape:SolidMolecular weight:438.5Polθ-IN-8
CAS:Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.Formula:C22H22ClN7O3SColor and Shape:SolidMolecular weight:499.97Dencatistat
CAS:Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.Formula:C24H27N7O5SPurity:98.85%Color and Shape:SolidMolecular weight:525.58Antiviral agent 67
CAS:Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.Formula:C19H19N3OColor and Shape:SolidMolecular weight:305.374CYP2C19-IN-1
CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.Formula:C26H26N2O6SColor and Shape:SolidMolecular weight:494.56Plevitrexed
CAS:Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.Formula:C26H25FN8O4Purity:98%Color and Shape:SolidMolecular weight:532.53PCNA-IN-1
CAS:PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.Formula:C19H18I3NO3Color and Shape:SolidMolecular weight:689.065DNA polymerase-IN-6
CAS:DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.Formula:C26H28ClFN8O4Color and Shape:SolidMolecular weight:571.003WRN inhibitor 13
CAS:WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.Formula:C16H20N2O5SColor and Shape:SolidMolecular weight:352.4052-CEES
CAS:2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.Formula:C4H9ClSColor and Shape:SolidMolecular weight:124.632And1 degrader 1
CAS:And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.Formula:C26H27Cl2N3OColor and Shape:SolidMolecular weight:468.42RAD51-IN-8
RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.Formula:C16H14Cl2FN3O2Color and Shape:SolidMolecular weight:370.21iPAF1C
CAS:iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].
Formula:C27H26BrFN4OColor and Shape:SolidMolecular weight:521.42DIDS
CAS:DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.Formula:C16H10N2O6S4Purity:98%Color and Shape:SolidMolecular weight:454.52Antitumor agent-75
Antitumor agent-75 is a novel and potent antitumor agent.Formula:C26H23FN6Color and Shape:SolidMolecular weight:438.5Methyl 3-oxodecanoate
CAS:Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.
Formula:C11H20O3Color and Shape:SolidMolecular weight:200.275HRO761
CAS:HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Formula:C31H31ClF3N9O5Purity:98.74% - 99.62%Color and Shape:SolidMolecular weight:702.08Ref: TM-T72107
1mg57.00€5mg118.00€10mg167.00€25mg280.00€50mg475.00€100mg708.00€1mL*10mM (DMSO)778.00€CTPS1-IN-1
CAS:CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Formula:C21H22N6O4S2Purity:99.46%Color and Shape:SolidMolecular weight:486.57SR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Formula:C26H32O2Purity:98.65%Color and Shape:SolidMolecular weight:376.53Ref: TM-T23384
1mg87.00€5mg144.00€10mg216.00€25mg376.00€50mg620.00€100mg938.00€1mL*10mM (DMSO)159.00€5'-O-DMT-N6-ibu-dA
CAS:5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Formula:C35H37N5O6Color and Shape:SolidMolecular weight:623.715'-DMT-3'-TBDMS-ibu-rG
CAS:5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Formula:C41H51N5O8SiColor and Shape:SolidMolecular weight:769.96Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Formula:C11H13N3O5Purity:98%Color and Shape:SolidMolecular weight:267.24NSC639828
CAS:NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Formula:C18H13BrClN5O3Color and Shape:SolidMolecular weight:462.69MitoE10
CAS:MitoE10 is an effective mitochondrial targeting antioxidant.Formula:C42H55O5PSColor and Shape:SolidMolecular weight:702.92
