DNA/RNA Synthesis

<p>5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innate</p>

<p>Carboxy pyridostatin trifluoroacetate salt exhibits higher molecular specificity for RNA over DNA G4s.</p>

<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>

<p>Hemsloside Ma 1 is a useful organic compound for research related to life sciences. The catalog number is T123850 and the CAS number is 95851-41-5.</p>

<p>Thio-ITP (6-Thioinosine 5'-triphosphate) inhibits RNA polymerases I &amp; II with Ki of 40.9 &amp; 38.0 μM.</p>

<p>7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase) and reduces TPase activity in a concentration-dependent manner, with an IC50 value of 40 μM. Additionally, 7-Deazaxanthine exhibits significant anti-angiogenic properties.</p>

<p>Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.</p>

<p>5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.</p>

<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>

<p>5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.</p>

<p>RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .</p>

<p>FR 901463 is a biochemical.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.</p>

<p>m7GpppGmpG, a trinucleotide 5′ cap analog, exhibits capping efficiencies of 86% for the RNAs obtained [1].</p>

<p>Maleuric acid is an anti-mitotic agent for research and boosts growth and fertility in flora and fauna.</p>

<p>16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.</p>

<p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.</p>

<p>wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.</p>

<p>T-2513 inhibits topoisomerase I by covalently bonding to its DNA complex, blocking DNA replication and causing cell death.</p>

<p>HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.</p>

<p>DMT-dU-CE Phosphoramidite is a nucleoside molecule commonly used for the synthesis and sequencing of DNA.</p>

<p>5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].</p>

<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>

<p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>

<p>WRN inhibitor 15 (Compound 9) is a WRN inhibitor with antitumor properties, displaying IC50 values of 37.9, 40.2, and 46.6 μM in PC3, LNCaP, and HeLa cells, respectively, making it suitable for prostate cancer research.</p>

<p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>

<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>

<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>

<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>

<p>LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.</p>

<p>Orotidine 5'-monophosphate trisodium, a pyrimidine nucleotide, is synthesized through the de novo DNA synthesis pathway by various microorganisms, including M.</p>

<p>M7GpppApG is a trinucleotide mRNA 5' cap analog utilized for in vitro RNA synthesis [1].</p>

<p>Nucleoside Derivatives - Indole nucleosides; Nucleoside Phosphoramidites</p>

<p>5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects.</p>

<p>5'-DMTr-T-Methyl phosphonamidite is a Nucleoside Derivative - phosphonamidite.</p>

<p>DMTr-TNA-5MeU-amidite is a Nucleoside Phosphoramidite.</p>

<p>5'-O-DMTr-N6-Fmoc-dA-phosphoramidite is a Nucleoside Phosphoramidite.</p>

<p>Nucleoside Phosphoramidites; Nucleoside Derivatives - LNA-related nucleosides</p>

<p>1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.</p>

<p>3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons.</p>

<p>Nucleoside Derivatives - LNA-related nucleosides; Nucleoside Phosphoramidites</p>

<p>5’-O-DMT-3’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>5'-DMTr-dA(Bz)-Methyl phosphonamidite is a Nucleoside Derivative - phosphonamidite.</p>

<p>Phosphoramidite (a modified phosphoramidite monomer) is utilized in the synthesis of oligonucleotides.</p>

<p>5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.</p>

<p>3'-F-3'-dA(Bz)-2'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - Fluoro-modified nucleoside.</p>

<p>DMT-dC(ac) Phosphoramidite is a phosphoramidite monomer that has been modified for use in oligonucleotide synthesis.</p>

<p>5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative that finds utility in oligonucleotide synthesis.</p>