Antibiotic

<p>Ikarugamycin, an antibiotic, is an inhibitor of clathrin-mediated endocytosis (CME).</p>

<p>Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.</p>

<p>Kazusamycin A is a new antitumor antibiotic.</p>

<p>Gliovirin: a fungicide from T. harzianum, combats P. ultimum and T. brucei, inactive against various fungi/bacteria, reduces COX-2 and IL-2 expression.</p>

<p>Formycin B is a model nucleoside analog.</p>

<p>Leucinostatin B is a peptide antibiotic from Paecilomyces lilacinus A-267.</p>

<p>Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.</p>

<p>Mandipropamid specifically induces complex formation between PYR1 and abscisic acid-insensitive hexameric mutants.</p>

<p>PD 116779 is a new antitumor antibiotic in the class os benz[a]anthraquinone.</p>

<p>Kijimicin is a polyether antibiotic and human immunodeficiency virus inhibitor in acutely and chronically infected cells.</p>

<p>Chloroorienticin A is an antibiotic in the class of glycopeptide.</p>

<p>Etimicin sulfate, a fourth-generation aminoglycoside antibiotic, is now widely used in clinical settings because of its high efficacy and low toxicity.</p>

<p>Anthramycin: a PBD family antibiotic with antitumor effects and CNS cholecystokinin antagonist properties in mice.</p>

<p>Kijanimicin: antitumor, antibiotic with unique activity against Gram-positive, anaerobic bacteria, and malaria.</p>

<p>Protorubradirin is an antibiotic that can be isolated from the non-pigmented Streptomyces achromogenes var. rubradiris alongside Rubradirin. It exhibits inhibitory activity against HIV reverse transcriptase. In vitro studies show that Protorubradirin also inhibits strains of Staphylococcus aureus and Streptococcus. In infected mice, subcutaneous administration of Protorubradirin demonstrates in vivo efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may significantly reduce its activity compared to Rubradirin, possibly due to its C-nitroso sugar decomposing more rapidly in acidic gastric conditions.</p>

<p>Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP)</p>

<p>PD 124895 is an antitumor antibiotic isolated from the fermentation broth of Streptomyces sp.</p>

<p>Oligomycin E, a Streptomyces metabolite, has weak antifungal properties but strong Gram-positive and HeLa cell antitumor effects (IC50=14 ng/ml).</p>

<p>(+)-Macrosphelide A, from Microsphaeropsis, thwarts HL-60 cell adhesion and SKOV3 cancer growth, fights Gram-positive bacteria, not Gram-negatives or fungi.</p>

<p>Oligomycin C is an antifungal agent isolated from Streptomyces strain.</p>