Antibacterial

<p>Biotin protein ligase-IN-1 (Compound Bio-9) is an inhibitor of biotin protein ligase (BPL) with a Kd of 7 nM. This compound exhibits antimicrobial activity, with minimum inhibitory concentration (MIC) values of 0.2 μM against Staphylococcus aureus (including MRSA and MSSA) and 20 μM against Mycobacterium tuberculosis.</p>

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>

<p>QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.</p>

<p>KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.</p>

<p>Ascr#18: nematode hormone boosts infection resistance in plants like Arabidopsis, tomato, potato, barley.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.</p>

<p>Thaxtomin A is a plant toxin that causes the death of plant cells.</p>

<p>RvD4, derived from docosahexaenoic acid, reduces neutrophil infiltration and promotes phagocytosis/clearance by human cells.</p>

<p>Arugomycin is an anthracycline natural product that functions as an antibiotic effective against Gram-positive bacteria. It has the ability to intercalate into DNA, giving it potential as an antitumor agent.</p>

<p>Kapurimycin A2 is an antitumor antibiotics.</p>

<p>Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.</p>

<p>NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.</p>

<p>ML338 is a potent inhibitor of dormant M. tuberculosis with IC90 of 1 μM and IC99 of 4 μM, aiding in tuberculosis research.</p>

<p>MMV1578877 is an inhibitor of Mycobacterium ulcerans with an IC50 of 0.37 μM. It is applicable in research related to Buruli ulcer (BU).</p>

<p>Ansatrienin B: antibiotic, antifungal, inhibits PTH-induced calcium release and protein synthesis, enhances certain chemotherapies.</p>

<p>Antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections</p>

<p>dmDNA31: a rifamycin antibiotic, inhibits bacterial RNA polymerase, strongly kills Staphylococcus aureus.</p>

<p>Actinorhodin is a blue pigment and a redox-active microbial secondary metabolite. It is a potent, antibacterial, pH-responsive antibiotic (antibiotic) exhibiting antimicrobial activity against Gram-positive bacteria.</p>

<p>Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.</p>

<p>Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.</p>

<p>Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity.</p>

<p>Flambalactone is a degradation product formed by methanolysis of the antibiotic flambamycin.</p>

<p>Flambamycin is an antibiotic isolated from Streptomyces hygroscopicus.</p>

<p>Setomimycin is an antibiotic against Gram positive bacteria, including mycobacteria.</p>

<p>Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.</p>

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>Efflux pump-IN-4 inhibits AcrB, enhancing antibiotic potency without harming bacterial membranes or nematodes.</p>

<p>Protein kinase G inhibitor-2 exhibits antibacterial, antiviral, and antitumor activities.</p>

<p>Baquiloprim: an antibiotic that inhibits bacterial dihydrofolate reductases; fights Gram-negative and Gram-positive bacteria.</p>

<p>Tomopenem is a penem antibiotic.</p>

<p>Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba &amp;amp; Aplysina aerophoba.</p>

<p>BAL30072: Antibiotic effective against MDR Acinetobacter (4 μg/mL) and P. aeruginosa (8 μg/mL); a monocyclic beta-lactam.</p>

<p>Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.</p>

<p>Hikizimycin is a potent anthelmintic and antibacterial natural product.</p>

<p>Protactin, a new antibiotic metabolite, is a possible precursor of the actinomycins.</p>

<p>Loloatin B 10 is a bioactive chemical.</p>

<p>Arylomycin B2 is an antibiotic and a potent inhibitor of signal peptidase I (SPase I), exhibiting activity against Gram-positive bacteria.</p>

<p>Kapurimycin A3 is an antitumor antibiotics.</p>

<p>Aurein 2.6, an antibiotic antimicrobial peptide, exhibits activity against various Gram-positive bacteria with minimum inhibitory concentrations (MIC) of 25, 25</p>

<p>Saccharothrixin F, an extensively oxygenated variant within the saccharothrixin class, exhibits antibacterial and anti-inflammatory properties.</p>

<p>EcAMP3, a hairpin-like peptide, exhibits both antifungal and antibacterial properties.</p>

<p>Hp1404 is a novel cationic antimicrobial peptide with specific inhibitory activity against Gram-positive bacteria, including Laburnetin-resistant Staphylococcus aureus (MRSA). Its antibacterial properties, low toxicity, and low likelihood of inducing resistance make it a useful candidate for antimicrobial agent research.</p>

<p>IN-2-LF, an inhibitor of lethal factor, also demonstrates inhibitory activity against furin, possessing an IC50 of 2 μM. Moreover, when used alongside D6R [1], IN-2-LF significantly enhances protection from anthrax lethal toxin.</p>

<p>Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.</p>

<p>Impurity B in Cefpodoxime Proxetil, a broad-spectrum oral antibiotic, is a third-generation cephalosporin.</p>

<p>Tibezonium iodide, an oropharyngeal disinfectant, possesses antibacterial properties that aid in preventing mouth infections [1].</p>

<p>DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE</p>

<p>Isodihydroauroglaucin is a useful organic compound for research related to life sciences. The catalog number is T124274 and the CAS number is 74886-31-0.</p>

<p>Anthracen-1-amine exhibits inhibitory activity against Escherichia coli.</p>

<p>Human Immunoglobulin G (HumanIgG) is an immunoglobulin that plays a protective role in humoral immunity by generating antibody responses against specific pathogens, such as Bacteroides forsythus and Prevotella intermedia. It serves as an antibody standard for quantification in enzyme-linked immunosorbent assays (ELISA). Additionally, Human Immunoglobulin G antibody levels are utilized in research on rheumatoid arthritis (RA) and periodontal disease.</p>

<p>Tryptophanase, a bacterial enzyme, catalyzes the degradation of tryptophan into indole, pyruvate, and ammonia [1].</p>

<p>Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.</p>

<p>LL-C 10037alpha is a gamma-aminoepoxysemiquinone isolated from Streptomyces.</p>

<p>JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.</p>

<p>Compound Fr13643, with CAS No. 622-62-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13643 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Desferriferribactin is a biogenetic precursor of pyoverdin.</p>

<p>Compound 15015-57-3, with CAS No. 15015-57-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 15015-57-3 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Ibezapolstat hydrochloride is an antibacterial agent.</p>

<p>Avilamycin A: antibiotic, combats C. perfringens and B. hyodysenteriae, lowers mortality in poultry.</p>

<p>(R)-Mucronulatol is a natural product that can be used as a reference standard. The CAS number of (R)-Mucronulatol is 57128-11-7.</p>

<p>Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.</p>

<p>Penicillin V: orally active antibiotic against Streptococci, C. difficile, and S. aureus; treats otitis, sinusitis, pharyngitis, tonsillitis.</p>

<p>Homo-BacPROTAC6, a ClpC1 NTD BacPROTAC degrader, effectively targets ClpC2, while Homo-BacPROTAC7 has been shown to efficiently kill M. tuberculosis [1].</p>

<p>PhoPS is a photoactivatable β-lactamase inhibitor. Upon exposure to light, PhoPS releases the active β-lactamase inhibitor Sulbactam. This compound is capable of inhibiting the synthesis of bacterial cell walls and the formation of biofilms in Escherichia coli, thereby exhibiting antibacterial activity.</p>

<p>DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.</p>

<p>Urdamycin B, an antibiotic derived from the metabolic products of Streptomyces fradiae, effectively inhibits fungi and bacteria, and exhibits anti-proliferative activity against mouse leukemia cells L1210. Its potential uses include research on cancer, bacterial, and fungal infections [1] [2].</p>

<p>Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.</p>

<p>Zelkovamycin, a cyclic peptide antibiotic, blocks X. oryzae, P. oryzae, S. aureus, A. laidlawii growth at 0.01-300 μg/ml concentration.</p>

<p>Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.</p>

<p>Nafcillin sodium: an antibiotic, β-lactamase inhibitor, treats staph infections.</p>

<p>(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) serves as an antitubercular agent, displaying a minimum inhibitory concentration (</p>

<p>PR-39 TFA, a peptide, noncompetitively inhibits proteasomes, spurring angiogenesis and reducing inflammation and mouse myocardial infarct size.</p>

<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>

<p>Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.</p>

<p>Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>elomycin is a cyclic depsipeptide antibiotic with activity against Gram-positive bacteria.</p>

<p>Amythiamicin D is a thiopeptide antibiotic that effectively inhibits the growth of various Gram-positive bacteria, but it is ineffective against Gram-negative bacteria such as Escherichia coli.</p>

<p>Bombinin H4 is an antimicrobial peptide originating from the skin of the moth species Bombina variegata.</p>

<p>Pristinamycin, from Streptomyces pristinaespiralis, is a streptogramin antibiotic targeting Gram-positive and resistant bacteria like MRSA.</p>

<p>DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM</p>

<p>Compound PDK0270, with CAS No. 551-16-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0270 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.</p>

<p>Dapdiamide A is an antibiotic identified in the Pantoea agglomerans CU0119 strain, displaying antibacterial activity and offering potential for research in anti-infective treatments.</p>

<p>Bipolamine G is an antibacterial polyketide alkaloid [1] .</p>

<p>Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1].</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).</p>

<p>FtsZ-IN-5: Potent inhibitor blocking bacterial division, low resistance and toxicity, enhances FtsZ polymerization.</p>

<p>Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB), with a MIC value of 6.25 µg/mL against MTB H37Rv. It demonstrates potent antitubercular activity by inhibiting mycolic acid biosynthesis, which is crucial for maintaining bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 holds potential for research in antitubercular agents.</p>

<p>Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.</p>

<p>Compound 16 is an antimicrobial with 4-8 μg/mL MIC, effective on gram-positive/negative bacteria and has anti-inflammatory properties.</p>

<p>LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.</p>

<p>Diaporthein B, a potent pimarane diterpene, inhibits M. tuberculosis (MIC: 3.1 μg/mL) and combats colon cancer cells (IC50: 1.5-3 μM/L).</p>

<p>3-Phenyl-1H-indole has antibacterial activity and can inhibit Klebsiella pneumoniae, Escherichia coli, Candida albicans, Staphylococcus aureus, etc.</p>

<p>Mupirocin calcium, an antibiotic from Pseudomonas fluorescens, halts bacterial protein and RNA synthesis.</p>

<p>(-)-Cleistenolide, an α,β-unsaturated δ-lactone derived from Cleistochlamys kirkii Oliver, exhibits antibacterial and antitumor activity [1].</p>

<p>Emeguisin A, a depsidone from E. unguis, fights S. aureus, MRSA, C. neoformans (MIC 0.5 μg/ml), and P. falciparum (IC50 2.2 μM).</p>

<p>Amycolatopsin A, a macrolide from Amycolatopsis, fights M. bovis/tuberculosis and some cancers, not effective on common bacteria.</p>

<p>Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.</p>