Antibacterial

BABX inhibits FAS-II, affecting fatty acid production in S. aureus/E. coli, and blocks LXRα agonist binding. IC50: 11.4/35.3 μg/ml. MIC: 0.2-0.4 μg/ml.

Biotin protein ligase-IN-1 (Compound Bio-9) is an inhibitor of biotin protein ligase (BPL) with a Kd of 7 nM. This compound exhibits antimicrobial activity, with minimum inhibitory concentration (MIC) values of 0.2 μM against Staphylococcus aureus (including MRSA and MSSA) and 20 μM against Mycobacterium tuberculosis.

Parvodicin C2, a glycopeptide antibiotic derived from A. parvosata and part of the parvodicin complex, serves as a component of the A40926 antibiotic complex utilized as a precursor for synthesizing dalbavancin. It exhibits activity against methicillin-sensitive and methicillin-resistant strains of S. aureus, S. epidermidis, S. saprophyticus, S. hemolyticus, and E. faecalis.

BO-1, a benzoate ester, exhibits antibacterial properties, effectively inhibiting multidrug-resistant Staphylococcus aureus.

6-Deoxy-8-O-methylrabelomycin is a useful organic compound for research related to life sciences.

3'-Hydroxyxanthyletin is a useful organic compound for research related to life sciences and the catalog number is T125640.

ML338 is a potent inhibitor of dormant M. tuberculosis with IC90 of 1 μM and IC99 of 4 μM, aiding in tuberculosis research.

(R)-Eucomol, a flavonoid derivative, exhibits slight antibacterial properties and demonstrates cytotoxic activity against KB and P-388 cells [1].

Baquiloprim: an antibiotic that inhibits bacterial dihydrofolate reductases; fights Gram-negative and Gram-positive bacteria.

Vecantoxatug is a humanized monoclonal antibody designed to target Clostridium tetani toxin (TeNT, a neurotoxin). It specifically binds to the tetanus toxin, preventing the toxin from interacting with cell receptors and thus exhibits antitoxin activity. Vecantoxatug holds potential for tetanus research.

Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics.

Elf18 is an N-terminal segment of the bacterial elongation factor Tu. In Arabidopsis, it acts as a pathogen-associated molecular pattern (PAMP) recognized by pattern recognition receptors (PRR), thereby triggering an immune response.

Caprazene is a precursor molecule of semi-synthetic antibacterial antibiotics and an anti-mycobacterial compound used for tuberculosis and Mycobacterium avium complex infection research. It can be isolated from the acid-treated caprazamycin (CPZ) A-G mixture.

Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.

Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

Corallopyronin A is an antibiotic that can be isolated from *Corallococcus coralloides* [1].

Enopeptin A: depsipeptide antibiotic with unique amino acids, combats Gram-positive/negative bacteria, not antifungal.

Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.

Cervinomycin A2 is an antibiotic effective against anaerobic bacteria, isolated from the Streptomyces genus, specifically Cervinomycetes. It exhibits strong inhibitory effects on Clostridium perfringens, Peptostreptococcus, and Bacteroides fragilis.

Antibacterialagent 272 (Compound Z22) is a potential antibacterial agent that targets the DNA and DNA-topoisomerase II (DNA-Topo II) complex. It exhibits strong antibacterial activity, with a minimum inhibitory concentration (MIC) of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853. Antibacterialagent 272 binds by intercalating between DNA base pairs, disrupting the normal function of bacterial DNA, and is suitable for research into bacterial infectious diseases.

Valanimycin is a biochemical.

17-hydroxy Venturicidin A: Streptomyces-derived macrolide with antibiotic and antifungal properties.

PMAP-23 is an antimicrobial peptide (AMP) with biological activity, derived from porcine myeloid cells.

LF11 displays antimicrobial activity.

Contezolid acefosamil sodium (MRX-4) is an oral antibiotic for drug-resistant Gram-positive cSSTIs, with low myelosuppression and MAOI risks.

Urease, made by various bacteria, aids pathogen virulence and is key to Helicobacter pylori's stomach colonization.

Enzyme-IN-2 (compound 15) serves as a potent urease inhibitor, exhibiting anti-ureolytic activity with a K i of 2.36 µM and an IC 50 of 0.75 µM [1].

Antibacterial agent 41 (example 3) is a antibacterial agent.

Arylomycin B6 is a lipoglycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.

Xinjiachalcone A, from Glycyrrhiza inflata, kills H. pylori effectively (MIC: 12.5-50 μM, 17 strains).

WU-FA-01, a hydrogenated WU-FA-00 derivative, has potent antibacterial effects on Gram-positive strains and anti-inflammatory properties.

D13-9001, an antibiotic, inhibits AcrB and MexB with KDs of 1.15μM in E. coli and 3.57μM in P. aeruginosa.

Bottromycin A2, an antibiotic from Streptomyces, halts protein synthesis and targets MRSA, VRE (MIC: 1, 0.5 μg/ml).

Tebipenem pivoxil HCl: oral antibiotic that targets PBPs to block bacterial cell wall synthesis.

The compound exhibits excellent antifungal and antiviral activities, including against HIV.

Compound IA-8, an aryl isoxazoline derivative, exhibits insecticidal efficacy against M. separate [1].

Bactenecin TFA, a 12-aa bovine peptide, disrupts membranes, stops bacterial/fungal growth, and hampers biofilms.

Tuberculosis inhibitor 9 (compound 3d), a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, exhibits potent activity against Mycobacterium tuberculosis and

Aldgamycin G is a Macrolide antibiotic against Gram-positive bacteria isolated from Streptomyces avidinii.

Cis-β-Terpineol, a monoterpene derived from the aerial parts of Anthemis turcomanica, exhibits antibacterial activity as evidenced by studies on the stems,

Lankacidinol A is a metabolite of macrolide antibiotic.

Salvinolone is a natural product that can be used as a reference standard.

Dicloxacillin, a β-Lactam antibiotic, targets beta-lactamase bacteria like Staphylococcus aureus, defeating penicillin resistance.

Ro 09-1428, a parenteral cephalosporin, has high antipseudomonal activity.

Antitubercular agent-41是一种抗菌剂。

Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. It exhibits antibacterial properties against both Gram-positive and Gram-negative bacteria, demonstrates inhibitory effects on fungi, and possesses moderate hemolytic activity on human red blood cells. Macropin is utilized in research for anti-infective therapies.

Sirpefenicol (ZTS-00007928), a phenicol antibacterial for treating animal bacterial infections.

Meloxicillin: a liver-excreted penicillin effective against Gram-negative and some Gram-positive bacteria; treats biliary infections.

Bio-AMS (TFA) inhibits bacterial biotin protein ligase, targets M. tuberculosis, and stops fatty acid/lipid synthesis.

Dihydronovobiocin: a coumarin antibiotic; fights S. aureus, S. haemolyticus, and others; inhibits DNA gyrase B (IC50: 64.5 nM).

Antibacterial Agent 42 boosts Ceftazidime's efficacy by lowering its MIC.

Flucloxacillin, an antibiotic, effectively combats both gram-positive and gram-negative bacteria [1] [2].

Sitafloxacin monohydrate (DU6859a) is a potent fluoroquinolone antibiotic with broad-spectrum anti-bacterial and anti-chlamydial effects.

Uvaretin demonstrates potent antibacterial activity against B. subtilis (EC50: 8.7 μM) and S. epidermidis (IC50: 7.9 μM).

HYNIC-UBI29-41 is composed of the bifunctional chelator HYNIC and the antimicrobial peptide UBI 29-41. It retains the antimicrobial properties of UBI 29-41, showing strong affinity for both Gram-positive and Gram-negative bacteria. When labeled with the radioactive element Technetium (99mTc), HYNIC-UBI29-41 can be used as an imaging agent for detecting bacterial infections in mouse models.

Ashimycin B is a streptomycin analogue that exhibits broad-spectrum antibacterial activity.

Gilvocarcin V, a metabolite from Actinomycete DO-38, exhibits potent antibacterial, antifungal, and antiviral activity.

NL3 is an inhibitor of bacterial cystathionine gamma-lyase, exhibiting IC50 values of 0.7 μM for [bCSE] and 3.4 μM for [hCSE]. It is applicable in research focused on antibacterial activity and overcoming bacterial resistance.

Melimine, a hybrid antimicrobial peptide derived from Melittin and Protamine, exhibits broad-spectrum activity against various microorganisms, including

Antibacterial agent 127 (Compound 23) is a potent antibacterial agent [1] .

Agent 38 from patent WO2015063714A1 (C) serves as an antibacterial for scientific study.

Kalimantacin A: a potent antibiotic effective against MRSA and other staphylococci.

SCH 38519, a fungal metabolite, inhibits thrombin, serotonin in platelets, and bacteria growth.

Antibacterialagent 233 (Compound 7c) demonstrates inhibitory activity against Helicobacter pylori, with a minimum inhibitory concentration (MIC) ranging from 0.4 to 1.6 μg/mL. It inhibits jack bean urease with an IC50 of 0.27 μg/mL, alters the permeability of the H. pylori cell membrane, and leads to the leakage of cellular contents. Antibacterialagent 233 shows metabolic stability in both whole blood and artificial gastric fluid. Additionally, it exhibits antitumor activity against U2OS in mice.

Compd 3j (Antibacterial agent 149) is a laccase inhibitor that exhibits potent fungicidal activity, particularly useful in researching rice sheath blight [1].

Nafcillin sodium: an antibiotic, β-lactamase inhibitor, treats staph infections.

Bryostatin 1, a marine macrolide, permeates CNS and modulates PKC, with strong affinity for Munc13-1 (Ki: 8.07 nM and 0.45 nM).

Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.

Quinaldopeptin: a quinomycin antibiotic, combats various bacteria, cytotoxic to cells, aids in P388 leukemia mouse survival, intercalates DNA.

Antituberculosis agent-9 (Compound 5a), an orally administered compound, demonstrates potent antitubercular activity, exhibiting a minimum inhibitory

(R)-Ofloxacin is a R-isomer of Ofloxacin, an antibiotic used to treat a number of bacterial infections.

Antituberculosis agent-5 is a small molecule used for high-throughput assays.

Antitubercular agent-9 exhibits potent activity against tuberculosis, demonstrating a minimum inhibitory concentration (MIC) range of 1.03-2.32 μM.

MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate that forms part of the antibody-antibiotic conjugate (AAC) molecule. It is synthesized by conjugating the linker with the antibiotic Gemcitabine. This compound is useful in studying the immunotherapy of bacterial infections and developing novel antibacterial drugs.

FR-202306 is a inhibitor of peptide deformylase (PDF).

Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)

Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.

Antituberculosis agent-13 (Compound 11) demonstrates antituberculosis activity, effectively inhibiting both wild-type and mutant strains of Mycobacterium tuberculosis, with an IC50 range of 4-62.5 nM. Additionally, Antituberculosis agent-13 exhibits anti-leukemia properties, inhibiting MOLM-13 with an IC50 of 3.8 μM.

MurA-IN-5 (compound 4c) demonstrates a minimum inhibitory concentration (MIC) of 1.95 μg/mL against Escherichia coli and exhibits significant potency as a MurA inhibitor with an IC50 of 3.77 μg/mL. It also shows antibiofilm activity against various microorganisms, indicating its potential in combating biofilm-related infections.

Antibacterial 128, a siderophore-Ciprofloxacin blend with cleavable linker, targets P. aeruginosa and B. pseudomallei.

FtsZ-IN-7: strong FtsZ inhibitor, blocks bacterial cell division, low resistance risk, minimal toxicity to mammals.

Abbeymycin is an antibiotic

Ro 24-6778 is a dual action cephalosporin with antimicrobial activity.

(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol, from Angelica sinensis, inhibits Aeromonas hydrophila and acts as an anticoagulant and antibiotic.

Chartreusin is an antibiotic. It also has anticancer activity.

Desacetylcefotaxime, a Cefotaxime metabolite, has strong antimicrobial effects against various bacteria.

Acetyl-L-homoserine lactone, a 2-carbon HSL, is inert in quorum sensing and does not trigger responses in E. coli or E. carotovora assays.

Clostomycin B2 is a bioactive chemical.

Picromycin is a macrolide antibiotic and PREP inhibitor effective against gram-positive bacteria, including mycobacteria.

TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks

Antibacterial agent 61 (example 27) is a antibacterial agent.

Methdilazine: oral antibiotic, histamine antagonist, fights mycobacterium (MIC 5-15 μg/mL) for infectious disease research.

Azidocillin, a semi-synthetic oral β-lactam antibiotic, treats various bacterial infections including osteitis and septicemia.

Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.

Antimicrobial agent-35 (Compound c9) demonstrates antibacterial activity, effectively inhibiting S. aureus, E. coli, E. faecalis, and S. maltophilia with a MIC of 0.5-2 μg/mL. Additionally, Antimicrobial agent-35 shows cytotoxicity towards HT-22 cells, with an IC50 value of 130.4 μg/mL.

Arylomycin A3 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.