Antibacterial

<p>MGB-BP-3 is a synthetic antibiotic with bactericidal activity that inhibits bacterial DNA replication and can be used to study recurrent C. difficile infections.</p>

<p>Sulfamethoxazole-d4 (Ro4-2130 D4) is a deuterium labeled Sulfamethoxazole, isotope tracing. Sulfamethoxazole is a sulfonamide antimicrobial agent.</p>

<p>CRAMP-18 (mouse) is an antibacterial peptide with no hemolytic activity. It exhibits significant inhibitory activity against Gram-negative bacteria, including S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) also shows potential for research in antifungal, antibacterial, and antitumor applications.</p>

<p>Deferasirox (Fe3+ chelate) is an iron chelator with anticancer activity and can be used to study iron overload.</p>

<p>D-(+)-Melezitose can be used to identify indole-positive and indole-negative Klebsiella clinical isolates.</p>

<p>3-oxo-C14-HSL is a quorum sensing signal that regulates genes and metabolism in bacteria, affecting biofilm and putisolvin production.</p>

<p>Polymyxin B1: potent lipopeptide against multidrug-resistant Gram-negative bacteria; from Bacillus polymyxa.</p>

<p>Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole.</p>

<p>Sulfapyridine D4 a deuterium labeled Sulfapyridine. Sulfapyridine is a agent of sulfonamide antibacterial.</p>

<p>Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi.</p>

<p>Balofloxacin is a fluoroquinolone antibiotic with oral activity.</p>

<p>Deuterium-labeled Sulfamethazine, an antimicrobial for treating animal diseases.</p>

<p>5-Hydroxypyrazine-2-Carboxylic Acid is a metabolite of anti-tuberculosis drug pyrazinamide.</p>

<p>Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative bacteria.</p>

<p>G907 is an antagonist of the ATP-binding cassette (ABC) transporter protein MsbA with bactericidal activity. G907 inhibits MsbA in E. coli.</p>

<p>Metronidazole-d4 is a deuterium labeled compound isotopic tracing.Metronidazole is an antibiotic and antiprotozoal oral and BBB penetration anaerobic bacteria.</p>

<p>Cefacetrile (Cephacetrile) is a cephalosporin antibiotic with antimicrobial activity for the study of Gramnegative infections.</p>

<p>Muramic acid is a prevalent constituent found in the cell walls of Gram-positive bacteria, serving as a distinguishing marker for such bacteria[1].</p>

<p>Iron (III) hexacyanoferrate (II) is a useful organic compound for research related to life sciences.</p>

<p>Chlorhexidine digluconate is a disinfectant with antibacterial activity that induces apoptosis and can be used to study bacterial infections.</p>

<p>Cefozopran hydrochloride (SCE-2787 hydrochloride) is a fourth-generation cephalosporin.</p>

<p>4-Acetamidophenyl acetate is an acetaminophen impurity, COX-2 inhibitor (IC50: 25.8 μM), and strong NAT2 inhibitor.</p>

<p>Enrofloxacin-d5 is a deuterium marker for Enrofloxacins.(BAY-Vp2674) is an antibiotic that acts against Mycoplasma bovis and has a MIC90 of 0.312 μg/mL.</p>

<p>Etoposide Phosphate is a selective and orally active topoisomerase II inhibitor and anticancer chemotherapy drug that apoptosise, the p53, and G2/M</p>

<p>Cefpiramide sodium (SM-1652; Wy-44635) is a Pseudomonas-active cephalosporin. It has a broad spectrum of antibacterial activity.</p>

<p>Lincomycin (U-10149) is a antibiotic against most susceptible gram-positive and cell wall-less bacteria .</p>

<p>Hydroxymetronidazole (Metronidazole-OH) is a nitroimidazole compound and metabolite of Metronidazole, commonly used in poultry research for bacterial and protozoal diseases, and in studies of swine dysentery and genital trichomoniasis in cattle.</p>

<p>Spectinomycin, a broad-spectrum antibiotic, halts protein synthesis in various bacteria by targeting ribosomes.</p>

<p>EDTA disodium dihydrate chelates metals, inhibits proteases, and aids in protein purification; doesn't affect cellulase.</p>

<p>Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor.</p>

<p>Bismuth subcarbonate, a bismuth-based semiconductor, has antibacterial uses, gastric protection, and applications in sensors and photocatalysts.</p>

<p>Terizidone is a derivate of cycloserine with bacteriostatic activity.</p>

<p>Phenazine is a dibenzo annulated pyrazine and the parent substance of many dyestuffs.</p>

<p>Linezolid D3, a deuterium-labeled version of Linezolid, is a synthetic antibiotic designed to halt the initiation of bacterial protein synthesis.</p>

<p>Sulbactam pivoxil is a prodrug of sulbactam, exhibiting oral bioavailability and superior absorption. Sulbactam functions as a β-lactamase inhibitor.</p>

<p>Gatifloxacin mesylate, a 4th-gen fluoroquinolone antibiotic, inhibits DNA gyrase and topoisomerase IV.</p>

<p>Tilbroquinol is an antiprotozoal agent effective against amoebiasis.</p>

<p>N-Butanoyl-DL-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.</p>

<p>Dibenzylideneacetone is a synthetic curcumin analog. It leads to apoptotic cell death in Leishmania donovani.</p>

<p>Troleandomycin is a macrolide antibiotic and is similar to Erythromycin.</p>

<p>Cefalexin hydrochloride is a cephalosporin antibiotic.</p>

<p>Deprodone propionate is a corticosteroid, made by esterifying prednisolone at the 17-position and deoxidizing at the 21-position with propionic acid.</p>

<p>Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.</p>

<p>Sulfadimethoxypyrimidine D4 is a deuterated sulfonamide antibiotic with broad-spectrum effects.</p>

<p>Cephalexin monohydrate (Cephalexin hydrate) is a cephalosporin antibiotic with significant antibacterial activity that inhibits bacterial proliferation.</p>

<p>Sulfadiazine D4 is a deuterium labeled Sulfadiazine. Sulfadiazine used for the treatment of toxoplasmosis.</p>

<p>Cefixime trihydrate, a third-gen cephalosporin antibiotic, treats bacterial infections.</p>

<p>"(±)-ε-Viniferin, a racemate of ε-Viniferin, exhibits P450 inhibitory antioxidants, along with hepato-protective and antimicrobial activities. It also demonstrates antibacterial and antibiofilm activities against Gram-positive bacteria Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) of 20 μM [1]."</p>

<p>Tosylchloramide sodium trihydrate is an agent of disinfectant. It is also used as a biocide in air fresheners and deodorants.</p>

<p>Morinidazole (R enantiomer) is the R-enantiomer of Morinidazole.</p>

<p>Nemonoxacin is a non-fluorinated quinolone antibiotic.</p>

<p>4-t-Butyl-benzhydroxamic Acid: PqsR antagonist, IC50 of 12.5 μM (E. coli), 23.6 μM (P. aeruginosa), lowers pyocyanin with IC50 87.2 μM.</p>

<p>Sulfathiazole D4 is a deuterium labeled Sulfathiazole. Sulfathiazole used as a short-acting sulfonamide antibiotic.</p>

<p>Lansoprazole D4 (AG-1749 D4) is a deuterium labeled Lansoprazole. Lansoprazole is an inhibitor of proton pump which prevents the stomach from producing acid.</p>

<p>Omadacycline tosylate (PTK 0796 tosylate) is an orally available antibacterial agent and tetracycline antibiotic, broad-spectrum antimicrobial activity.</p>

<p>Citrinin: a mycotoxin with antifungal, antibacterial, potential anticancer, and neuroprotective properties; contaminates food.</p>

<p>Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.</p>

<p>Sulfamerazine D4 is deuterium-labeled, a sulfonamide that blocks bacterial folic acid production by binding instead of PABA.</p>

<p>Compound Fr14273 is a natural product for research related to life sciences. The catalog number is Fr14273 and the CAS number is 551-93-9.</p>

<p>Propylparaben sodium, a plant-based preservative used in cosmetics, pharma, and food, hinders follicle growth and sperm health.</p>

<p>STC314 has anti-infective properties and can be used to study sepsis and inhibit platelet activation and red blood cell damage.</p>

<p>Duramycin, a cyclic peptide from Streptomyces, targets PE, offering antibacterial and antiviral properties, and may treat cystic fibrosis.</p>

<p>2-Chloroacetamide: a preservative, herbicide, and biocide used in agriculture, glues, paints, with inhibitory effects on fatty acid elongase.</p>

<p>Carindacillin sodium, orally active broad-spectrum antibiotic, hydrolyzes to Carbenicillin, used in urinary tract infection studies.</p>

<p>Heparin Lithium salt is an anticoagulant that reversibly binds to ATIII and enhances its inhibitory effect on coagulation factor(thrombin and factor Xa).</p>

<p>N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL), a quorum-sensing signaling molecule synthesized by P. aeruginosa and specific B. cepacia complex strains [1][2], facilitates bacterial gene expression modulation in response to cell density escalation and triggers IL-8 production in 16HBE human bronchial epithelial cells [3].</p>

<p>Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI)</p>

<p>Gloxazone is an effective anaplasmacide with toxicity.</p>

<p>G-418, or Geneticin, is an aminoglycoside antibiotic similar to gentamicin; it's toxic to all cells and blocks protein synthesis.</p>

<p>Ceftolozane (FR-264,205 or CXA-101) is a cephalosporin antibiotic for drug-resistant gram-negative and gram-positive infections, used with tazobactam.</p>

<p>Enrofloxacin monohydrochloride, an antibiotic, has MIC 90 of 0.312 μg/mL for M. bovis and inhibits vaccinia virus.</p>

<p>Triclosan-methyl, derived from bactericidal triclosan, is used in toothpaste, shampoos, soaps, detergents, and cosmetics.</p>

<p>Cefditoren sodium: cephalosporin antibiotic for bacterial infections; alters Mrp2, Bcrp, Oat2, P-gp, Oct1 mRNA levels.</p>

<p>Pivampicillin, a pivalate ester analog of Ampicillin, is used to treat chronic obstructive pulmonary disease (COPD) in children and young adults.</p>

<p>Methylisothiazolinone is a powerful synthetic biocide and preservative.</p>

<p>Rosuvastatin Sodium: HMGCR inhibitor, blocks hERG (IC50: 11 nM, 195 nM), reduces hERG expression, hinders Hsp70-hERG interaction.</p>

<p>Decamethoxine is a biochemical.</p>

<p>Cefepime dihydrochloride: fourth-gen cephalosporin, inhibits bacterial PBPs.</p>

<p>Deshydroxyethoxy ticagrelor (AR-C124910) is a metabolite of Ticagrelor that exhibits antibacterial activity against MRSA and possesses antiplatelet effects.</p>

<p>Bromperidol hydrochloride is a D2 dopamine receptor antipsychotic; enhances Spectinomycin's mycobactericidal effects.</p>

<p>Tosufloxacin is a fluoroquinolone antibiotic used to treat susceptible infections.</p>

<p>Alafosfalin is a Chemotherapeutic agent.</p>

<p>Gentamicin C1a, a major component with antibacterial activity, is the precursor to Etimicin.</p>

<p>Chloramphenicol-d5 is a deuterated compound of Chloramphenicol. Chloramphenicol has a CAS number of 56-75-7. Chloramphenicol, a broad-spectrum antibiotic, blocks bacterial protein synthesis.</p>

<p>Vitamin D3-d3 is a deuterated compound of Vitamin D3.</p>

<p>Florfenicol-d3 is a deuterated compound of Florfenicol.</p>

<p>SMARt751 targets the transcriptional regulator VirS, inhibiting its ability to bind DNA, which in turn enhances the expression of the mymA operon and activates Ethionamide. This activation increases the antimicrobial efficacy of Ethionamide against Mycobacterium tuberculosis, and overcomes its resistance. Furthermore, SMARt751 augments Ethionamide's antibacterial activity in mouse models and reduces its effective dose. Additionally, SMARt751 can permeate the blood-brain barrier.</p>

<p>Avibactam tomilopil (AV-006) is an oral prodrug of Avibactam, inhibiting class A and C β-lactamases, including ESBLs, AmpC, and KPC, antibacterial.</p>

<p>Ofloxacin-d3 is a deuterated compound of Ofloxacin.</p>

<p>Sarafloxacin-d8 Hydrochloride is a deuterated compound of Sarafloxacin Hydrochloride. Sarafloxacin Hydrochloride has a CAS number of 91296-87-6. Sarafloxacin hydrochloride, a quinolone antibiotic drug, is a hydrochloride salt form of sarafloxacin.</p>

<p>Dexamethasone-d5 is a deuterated compound of Dexamethasone.</p>

<p>Pyrazinamide-d3 is a deuterated compound of Pyrazinamide. Pyrazinamide has a CAS number of 98-96-4. Pyrazinamide, an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.</p>

<p>Spectinomycin sulfate hydrate is a broad-spectrum antibiotic capable of inhibiting the growth of various Gram-positive and Gram-negative bacteria. It targets bacterial ribosomes specifically, thereby disrupting protein synthesis. Additionally, spectinomycin sulfate hydrate acts as a non-competitive inhibitor of td intron RNA, with a Ki of 7.2 mM.</p>

<p>Acyclovir-d4 is a deuterated compound of Acyclovir. Acyclovir has a CAS number of 59277-89-3. Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.</p>

<p>Fenvalerate (Evercide 2362) is a protein phosphatase 2B (calcineurin) inhibitor, a synthetic pyrethroid insecticide, that inhibits PP2B-Aα.</p>

<p>Gepotidacin is a triazaacenaphthylene antibacterial inhibiting bacterial type II topoisomerase with lower resistance potential than fluoroquinolones.</p>

<p>Acridine-9-carboxaldehyde is an acridine derivative that functions as a pH indicator for fluorescence lifetime measurements.</p>

<p>OES2-0017 exhibits strong synergistic effects and growth inhibition in collaboration with polyamines within a low micromolar range. At low concentrations, OES2-0017 inhibits spermidine/spermine N1-acetyltransferase (SpeG) (IC50: 34.82 μM) and other polyamine detoxifying enzymes, while at higher concentrations, it disrupts bacterial membranes.</p>

<p>Acyclovir (Aciclovir) hydrochloride is an effective oral antiviral agent with potent anti-herpetic activity. It exhibits IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2, indicating strong inhibitory effects against these strains. Additionally, Acyclovir hydrochloride induces cell cycle disturbances and apoptosis. This compound also prevents bacterial infections during induction therapy for acute leukemia.</p>

<p>Primulasaponin 1 is a useful organic compound for research related to life sciences. The catalog number is T124469 and the CAS number is 65312-86-9.</p>