Antibacterial

<p>Fosfomycin is an antibiotic that is produced by Streptomyces fradiae.</p>

<p>Benzylpenicillin, a penicillin derivative, treats infections using sodium or potassium salts. Effective against gram-positive bacteria and gram-negative cocci.</p>

<p>SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.</p>

<p>Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.</p>

<p>2,4,6-trichloroanisole inhibits the cell viability of CHO and C32 cell lines and apoptosis, antibacterial activity against Plasmodium falciparum.</p>

<p>PD-L1/LpxC-IN-1 (Compound 12b) is an inhibitor of PD-L1 and LpxC, with IC50 values of 5.2 μM and 0.081 μM, respectively. This compound disrupts bacterial lipopolysaccharide biosynthesis, leading to bacterial cell lysis and death. It effectively inhibits Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL against K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028, and P. aeruginosa ATCC 9027. Additionally, PD-L1/LpxC-IN-1 modulates the immune response by downregulating the expression of inflammatory cytokines IL-2 and IFN-γ, and upregulating CD4+ and CD8+ cells, thus activating the immune system and mitigating excessive inflammatory responses. In a mouse model of K. pneumoniae ATCC 13883 infection, PD-L1/LpxC-IN-1 demonstrated antibacterial activity.</p>

<p>Batzelladine D inhibits Pdr5p, with IC50 of 7.1 µM, and exhibits antifungal, antiparasitic, antiviral, antibacterial, and antitumor properties.</p>

<p>Arylomycin B7 is a lipohexapeptide antibiotic (antibiotic) that specifically targets Gram-positive bacteria.</p>

<p>Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases.</p>

<p>Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.</p>

<p>Dehydrolycopene, a major SGA in tomatoes' green fruits, leaves, and flowers, targets bacteria, fungi, insects, and animals.</p>

<p>Sparsomycin is an antitumor antibiotic. It also inhibits protein synthesis in the 70S and 80S ribosomal systems.</p>

<p>Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.</p>

<p>Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.</p>

<p>Zifanocycline: 3rd-gen aminomethylcycline antibiotic, broad-spectrum against resistant bacteria, oral/injectable, for various infections.</p>

<p>Zifanocycline (KBP-7072) TFA is a semi-synthetic aminomethylcycline antibiotic with oral bioavailability, targeting bacterial ribosomes to impede their function</p>

<p>Pseudomonic acid D is a topical antibiotic agent used against superficial skin infections such as impetigo or folliculitis.</p>

<p>Sperabillin A (free base) is a potent antibacterial antibiotic in vivo isolated from Pseudomonas fluorescens YK-437.</p>

<p>Compound 12: potent antimicrobial with 2-8 μg/mL MIC, effective against Gram-positive/negative bacteria; anti-inflammatory.</p>

<p>DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.</p>