Antibacterial

<p>Compound Fr13643, with CAS No. 622-62-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13643 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Luminamicin is active against anaerobic bacteria, especially Clostridium sp.; isolated from actinomycete strain OMR-59.</p>

<p>Antibacterial agent 50 targets E. coli strains with MICs: 32 mcg/mL for NCTC 13351, 64 for M 50, and 128 for 7 MP.</p>

<p>Ibezapolstat hydrochloride is an antibacterial agent.</p>

<p>Avilamycin A: antibiotic, combats C. perfringens and B. hyodysenteriae, lowers mortality in poultry.</p>

<p>Aurein 2.4, an antibiotic antimicrobial peptide, exhibits activity against Gram-positive bacteria [1] [2].</p>

<p>Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.</p>

<p>Penicillin V: orally active antibiotic against Streptococci, C. difficile, and S. aureus; treats otitis, sinusitis, pharyngitis, tonsillitis.</p>

<p>WU-FA-01, a hydrogenated WU-FA-00 derivative, has potent antibacterial effects on Gram-positive strains and anti-inflammatory properties.</p>

<p>Aurodox is a biochemical.</p>

<p>DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.</p>

<p>Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.</p>

<p>Zelkovamycin, a cyclic peptide antibiotic, blocks X. oryzae, P. oryzae, S. aureus, A. laidlawii growth at 0.01-300 μg/ml concentration.</p>

<p>Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.</p>

<p>Ro 25-0534 is an antipseudomonal dual-action drug with antimicrobial activity.</p>

<p>IspE kinase-IN-1 (compound 4) is a potent inhibitor of IspE kinase, exhibiting IC50 values of 6.2 µM against EclspE and 5.2 µM against KplspE.</p>

<p>Maximin 2, an antimicrobial peptide sourced from the skin secretions of Bombina maxima, exhibits cytotoxicity in tumor cells and possesses spermicidal</p>

<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>

<p>Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.</p>

<p>Bombinin-Like Peptide (BLP-1) is an antimicrobial peptide from Bombina species.</p>