Antibacterial

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>Emeguisin A, a depsidone from E. unguis, fights S. aureus, MRSA, C. neoformans (MIC 0.5 μg/ml), and P. falciparum (IC50 2.2 μM).</p>

<p>K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.</p>

<p>Dapdiamide A is an antibiotic identified in the Pantoea agglomerans CU0119 strain, displaying antibacterial activity and offering potential for research in anti-infective treatments.</p>

<p>Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity [1] .</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>

<p>Compound PDK0270, with CAS No. 551-16-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0270 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>HBA(111-142), a C-terminal 32-mer fragment of alpha-hemoglobin, exhibits antibacterial activity against the ESKAPE panel of pathogens, forms amyloid fibrils,</p>

<p>Moenomycin complex is a mixture of moenomycins A, A12, C1, C3 and C4, which are antibiotics from several Streptomyces that directly inhibit bacterial PGTs.</p>

<p>Amythiamicin D is a thiopeptide antibiotic that effectively inhibits the growth of various Gram-positive bacteria, but it is ineffective against Gram-negative bacteria such as Escherichia coli.</p>

<p>Maximin H3, an antimicrobial peptide from Chinese red belly toad Bombina maxima skin secretions, exhibits antimicrobial properties against Escherichia coli</p>

<p>elomycin is a cyclic depsipeptide antibiotic with activity against Gram-positive bacteria.</p>

<p>SPR741, a cationic peptide from polymyxin B, is being developed to treat serious Gram-negative infections.</p>

<p>Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.</p>

<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>

<p>cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.</p>

<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>

<p>Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.</p>

<p>Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.</p>