Antibacterial

ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.

Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.

Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.

Altromycin E is a new pluramycin-like antibiotic.

Pyrocoll, from Streptomyces, stops various bacteria and cancer cells; active against P. falciparum, T. rhodesiense.

Lytixar (LTX-109): Synthetic peptide effective against various resistant S. aureus strains, MIC 2-4 μg/ml, fast-acting regardless of prior resistance.

PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.

Teixobactin is a recently described antibiotic .

Quorum sensing involves bacteria using AHLs to coordinate gene expression for biofilm formation and virulence, via LuxR regulators.

Pomolic Acid 3-Acetate, an antitubercular compound, exhibits a minimum inhibitory concentration (MIC) of 32 μM against Mycobacterium tuberculosis H37Rv [1].

Tebipenem pivoxil HCl: oral antibiotic that targets PBPs to block bacterial cell wall synthesis.

Antibacterial agent 162 trifluoromethanesulfonate (compound 7), a dual-function molecule, demonstrates potent inhibitory effects on Staphylococcus aureus,

Hikizimycin is a potent anthelmintic and antibacterial natural product.

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) serves as an antitubercular agent, displaying a minimum inhibitory concentration (

Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.

Collismycin A, from Streptomyces, has antibacterial, antiproliferative, and neuroprotective effects. It inhibits various cancer cells and is iron-complexing.

CAY10742: Oral oxadiazole antibiotic, combats Gram-positive bacteria & MRSA, effective against resistant strains, works in mouse models. MICs = 1-4 μg/ml.

Arylomycin B2 is an antibiotic and a potent inhibitor of signal peptidase I (SPase I), exhibiting activity against Gram-positive bacteria.

cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.