Antibacterial

Bio-AMS (TFA) inhibits bacterial biotin protein ligase, targets M. tuberculosis, and stops fatty acid/lipid synthesis.

Dihydronovobiocin: a coumarin antibiotic; fights S. aureus, S. haemolyticus, and others; inhibits DNA gyrase B (IC50: 64.5 nM).

Antibacterial Agent 42 boosts Ceftazidime's efficacy by lowering its MIC.

Flucloxacillin, an antibiotic, effectively combats both gram-positive and gram-negative bacteria [1] [2].

Sitafloxacin monohydrate (DU6859a) is a potent fluoroquinolone antibiotic with broad-spectrum anti-bacterial and anti-chlamydial effects.

Uvaretin demonstrates potent antibacterial activity against B. subtilis (EC50: 8.7 μM) and S. epidermidis (IC50: 7.9 μM).

HYNIC-UBI29-41 is composed of the bifunctional chelator HYNIC and the antimicrobial peptide UBI 29-41. It retains the antimicrobial properties of UBI 29-41, showing strong affinity for both Gram-positive and Gram-negative bacteria. When labeled with the radioactive element Technetium (99mTc), HYNIC-UBI29-41 can be used as an imaging agent for detecting bacterial infections in mouse models.

Ashimycin B is a streptomycin analogue that exhibits broad-spectrum antibacterial activity.

Gilvocarcin V, a metabolite from Actinomycete DO-38, exhibits potent antibacterial, antifungal, and antiviral activity.

NL3 is an inhibitor of bacterial cystathionine gamma-lyase, exhibiting IC50 values of 0.7 μM for [bCSE] and 3.4 μM for [hCSE]. It is applicable in research focused on antibacterial activity and overcoming bacterial resistance.

Melimine, a hybrid antimicrobial peptide derived from Melittin and Protamine, exhibits broad-spectrum activity against various microorganisms, including

Antibacterial agent 127 (Compound 23) is a potent antibacterial agent [1] .

Agent 38 from patent WO2015063714A1 (C) serves as an antibacterial for scientific study.

Kalimantacin A: a potent antibiotic effective against MRSA and other staphylococci.

SCH 38519, a fungal metabolite, inhibits thrombin, serotonin in platelets, and bacteria growth.

Antibacterialagent 233 (Compound 7c) demonstrates inhibitory activity against Helicobacter pylori, with a minimum inhibitory concentration (MIC) ranging from 0.4 to 1.6 μg/mL. It inhibits jack bean urease with an IC50 of 0.27 μg/mL, alters the permeability of the H. pylori cell membrane, and leads to the leakage of cellular contents. Antibacterialagent 233 shows metabolic stability in both whole blood and artificial gastric fluid. Additionally, it exhibits antitumor activity against U2OS in mice.

Compd 3j (Antibacterial agent 149) is a laccase inhibitor that exhibits potent fungicidal activity, particularly useful in researching rice sheath blight [1].

Nafcillin sodium: an antibiotic, β-lactamase inhibitor, treats staph infections.

Bryostatin 1, a marine macrolide, permeates CNS and modulates PKC, with strong affinity for Munc13-1 (Ki: 8.07 nM and 0.45 nM).

Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.

Quinaldopeptin: a quinomycin antibiotic, combats various bacteria, cytotoxic to cells, aids in P388 leukemia mouse survival, intercalates DNA.

Antituberculosis agent-9 (Compound 5a), an orally administered compound, demonstrates potent antitubercular activity, exhibiting a minimum inhibitory

(R)-Ofloxacin is a R-isomer of Ofloxacin, an antibiotic used to treat a number of bacterial infections.

Antituberculosis agent-5 is a small molecule used for high-throughput assays.

Antitubercular agent-9 exhibits potent activity against tuberculosis, demonstrating a minimum inhibitory concentration (MIC) range of 1.03-2.32 μM.

MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate that forms part of the antibody-antibiotic conjugate (AAC) molecule. It is synthesized by conjugating the linker with the antibiotic Gemcitabine. This compound is useful in studying the immunotherapy of bacterial infections and developing novel antibacterial drugs.

FR-202306 is a inhibitor of peptide deformylase (PDF).

Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)

Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.

Antituberculosis agent-13 (Compound 11) demonstrates antituberculosis activity, effectively inhibiting both wild-type and mutant strains of Mycobacterium tuberculosis, with an IC50 range of 4-62.5 nM. Additionally, Antituberculosis agent-13 exhibits anti-leukemia properties, inhibiting MOLM-13 with an IC50 of 3.8 μM.

MurA-IN-5 (compound 4c) demonstrates a minimum inhibitory concentration (MIC) of 1.95 μg/mL against Escherichia coli and exhibits significant potency as a MurA inhibitor with an IC50 of 3.77 μg/mL. It also shows antibiofilm activity against various microorganisms, indicating its potential in combating biofilm-related infections.

Antibacterial 128, a siderophore-Ciprofloxacin blend with cleavable linker, targets P. aeruginosa and B. pseudomallei.

FtsZ-IN-7: strong FtsZ inhibitor, blocks bacterial cell division, low resistance risk, minimal toxicity to mammals.

Abbeymycin is an antibiotic

Ro 24-6778 is a dual action cephalosporin with antimicrobial activity.

(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol, from Angelica sinensis, inhibits Aeromonas hydrophila and acts as an anticoagulant and antibiotic.

Chartreusin is an antibiotic. It also has anticancer activity.

Desacetylcefotaxime, a Cefotaxime metabolite, has strong antimicrobial effects against various bacteria.

Acetyl-L-homoserine lactone, a 2-carbon HSL, is inert in quorum sensing and does not trigger responses in E. coli or E. carotovora assays.

Clostomycin B2 is a bioactive chemical.

Picromycin is a macrolide antibiotic and PREP inhibitor effective against gram-positive bacteria, including mycobacteria.

TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks

Antibacterial agent 61 (example 27) is a antibacterial agent.

Methdilazine: oral antibiotic, histamine antagonist, fights mycobacterium (MIC 5-15 μg/mL) for infectious disease research.

Azidocillin, a semi-synthetic oral β-lactam antibiotic, treats various bacterial infections including osteitis and septicemia.

Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.

Antimicrobial agent-35 (Compound c9) demonstrates antibacterial activity, effectively inhibiting S. aureus, E. coli, E. faecalis, and S. maltophilia with a MIC of 0.5-2 μg/mL. Additionally, Antimicrobial agent-35 shows cytotoxicity towards HT-22 cells, with an IC50 value of 130.4 μg/mL.

Arylomycin A3 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.