Antibacterial
Antibacterial inhibitors are compounds that target bacterial cells, inhibiting their growth or killing them outright. These inhibitors are essential in the development of treatments for bacterial infections and are widely used in research to study bacterial physiology, resistance mechanisms, and the efficacy of new antibacterial agents. At CymitQuimica, we offer a range of antibacterial inhibitors to support your research in microbiology, infectious diseases, and drug development.
Found 3421 products of "Antibacterial"
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Antibiofilm agent-4
CAS:Antibiofilm agent-4 is a LasR inhibitor, demonstrating optimal antibiofilm and anti-QS (quorum sensing) properties.Formula:C15H15NO3Molecular weight:257.28Cetefloxacin
CAS:Cetefloxacin (E 4868) is a broad-spectrum antibacterial antibiotic with a minimum inhibitory concentration (MIC) ranging from 0.007 to 8 µg/ml. In mice, cetefloxacin demonstrates favorable pharmacokinetic properties and provides protection against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.Formula:C20H16F3N3O3Molecular weight:403.35DNA ligase-IN-2
CAS:DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.Formula:C13H8FN3O3Color and Shape:SolidMolecular weight:273.2192'-Amino-2'-deoxyadenosine
CAS:2'-Amino-2'-deoxyadenosine (9-(2-Amino-2-deoxypentofuranosyl)-9H-purin-6-amine) is a nucleoside antibiotic that effectively inhibits various Mycoplasma strains.Formula:C10H14N6O3Color and Shape:SolidMolecular weight:266.26TBAJ-5307
CAS:TBAJ-5307 is a broad-spectrum anti-non-tuberculous mycobacteria inhibitor that targets the FO-domain of the engine, preventing rotation and proton-translocation. TBAJ-5307 inhibits non-tuberculous mycobacteria in vitro and in vivo [1].Formula:C30H35BrN4O6Color and Shape:SolidMolecular weight:627.53BDM91288
CAS:BDM91288, an orally active AcrB efflux pump inhibitor of pyridinium piperazine, enhances the in vivo efficacy of levofloxacin in treating Klebsiella pneumoniae pulmonary infection in mouse models [1].Formula:C17H22ClN5Color and Shape:SolidMolecular weight:331.84NDM-1 inhibitor-5
CAS:NDM-1 Inhibitor-5 (compound 57) exhibits strong inhibition of NDM-1, characterized by a K i of 2.5 μM. Additionally, it demonstrates synergistic antibacterial effects when combined with meropenem [1].Formula:C24H23NO4Color and Shape:SolidMolecular weight:389.44Antibacterial agent 204
CAS:Antibacterial agent 204 (Compd P2-56-3) enhances the activity of Rifampin (RIF) against Acinetobacter baumannii and Klebsiella pneumoniae by disrupting the outer membrane of A. baumannii. T [1].Formula:C14H18N2Color and Shape:SolidMolecular weight:214.31Pneumolysin-IN-1
CAS:Pneumolysin-IN-1 (compound PB-3), characterized as a targeted small molecule inhibitor of Pneumolysin (PLY) with an IC50 value of 3.1 µM, acts as a pore-blocking agent and an anti-virulence factor. This compound is useful for researching infections caused by Streptococcus pneumoniae [1].Formula:C23H16Cl2N2O4Color and Shape:SolidMolecular weight:455.29LasR antagonist 1
CAS:LasR antagonist 1 (Compound 7), with an IC50 of 0.4 μM, is an effective antagonist of LasR that modulates quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa [1].Formula:C20H15F3N2O3Color and Shape:SolidMolecular weight:388.34MA220607
CAS:MA220607 is an antibacterial agent characterized by low hemolytic toxicity and a dual-target mechanism of action (MOA). It promotes FtsZ protein polymerization, increases bacterial membrane permeability, and inhibits biofilm formation. The resistance rate of MA220607 is low, with MICs against Gram-positive bacteria and Gram-negative bacteria ranging from 0.062-2 μg/mL and 0.5-4 μg/mL, respectively [1].Formula:C34H38INColor and Shape:SolidMolecular weight:587.58HKI12134085
CAS:HKI12134085 (compound 3), an orally administered nitrobenzothiazinone (BTZ) derivative, demonstrates antibacterial efficacy against Mycobacterium tuberculosis. This compound exhibits significant in vivo inhibitory potency within a BALB/c mouse model of Mycobacterium tuberculosis infection [1].Formula:C18H18F3N3O5SColor and Shape:SolidMolecular weight:445.41N-Cbz-L-Cysteine
CAS:N-Cbz-L-Cysteine (Cbz-cysteine) (compound 5) functions as a potent inhibitor of β-lactamase II, exhibiting a K i value of 97 µM [1].Formula:C11H13NO4SColor and Shape:SolidMolecular weight:255.29MBL-IN-5
CAS:MBL-IN-5 is an inhibitor of metallo-β-lactamase (MBL). It effectively suppresses three clinically significant B1 subfamily MBLs: NDM-1, VIM-1, and IMP-1 with IC50 values of 0.05 nM, 14 nM, and 21 nM respectively. MBL-IN-5 notably enhances the efficacy of carbapenem antibiotics against MBL-producing clinical strains and, when combined with IPM antibiotics, significantly reduces bacterial load in a thigh infection model.Formula:C20H16ClNO3Color and Shape:SolidMolecular weight:353.80H052
CAS:H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.Formula:C21H15ClFN3O4SColor and Shape:SolidMolecular weight:459.88OSUAB-0284
CAS:OSUAB-0284 is an inhibitor of bacterial topoisomerase. It exhibits significant activity against staphylococci, particularly methicillin-resistant Staphylococcus aureus (MRSA). The compound exerts its antibacterial effect by inhibiting bacterial topoisomerase and may be used in research on infections caused by drug-resistant bacteria, including MRSA.Formula:C22H23FN6O6Color and Shape:SolidMolecular weight:486.45Antibacterial agent 278
CAS:Antibacterialagent 278 (compound B1) is an antimicrobial agent that exhibits potent inhibitory activity against Gram-positive bacteria.Formula:C24H17ClF2N4O3Color and Shape:SolidMolecular weight:482.87Antibacterial agent 169
CAS:Antibacterial agent 169 (Compound 28), a pyrrolamide-type GyrB/ParE inhibitor, exhibits antibacterial properties by inhibiting Gyrase and Topo IV in Staphylococcus aureus. It has IC 50 values of 49 nmol/L and 1.513 μmol/L, respectively [1].Formula:C19H25Cl2N5O3Color and Shape:SolidMolecular weight:442.34Metallo-β-lactamase-IN-13
CAS:Metallo-β-lactamase-IN-13 (Compound 13i) serves as a pan Metallo-β-Lactamase inhibitor with extended activity against Gram-negative (GN) bacteria expressing metallo-β-lactamases. It exhibits antibacterial properties effective against P. aeruginosa [1].Formula:C15H10F3N7O2S2Color and Shape:SolidMolecular weight:441.41InhA-IN-7
CAS:InhA-IN-7 (Compound 11), a derivative of Triclocan, shows inhibitory activity against enoyl-acyl carrier protein reductase (InhA) with an IC50 of 96 nM. It effectively inhibits the proliferation of both wildtype and mutant strains of Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MICs) ranging from 19 to 75 μM [1].Formula:C17H18Cl2O2Color and Shape:SolidMolecular weight:325.23JPL
CAS:JPL is an InhA-cofactor-ligand 3FNG inhibitor and is used for the study of tuberculosis [1].Formula:C19H20Cl2O2Color and Shape:SolidMolecular weight:351.27Altersolanol A
CAS:Altersolanol A (Stemphylin; NSC 173943) demonstrates effective antimicrobial properties, inhibiting the growth of Bacillus subtilis and Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) ranging from 25-100 μg/mL. Additionally, it shows no phytotoxic effects on Taxus at a concentration of 4 μg/μL.Formula:C16H16O8Color and Shape:SolidMolecular weight:336.29BioA-IN-1
CAS:BioA-IN-1 (Compound 15) is an inhibitor of the key enzyme BioA in the biotin biosynthesis pathway of Mycobacterium tuberculosis, with an IC50 value of 0.195 μM. It exhibits antibacterial activity without cytotoxicity.Formula:C18H17NO3SColor and Shape:SolidMolecular weight:327.397Antibacterial agent 174
CAS:Compound 174 (Compound 5g), an antibacterial agent, exhibits potent anti-infective properties in vivo along with appreciable pharmacokinetic profiles. This highly active substance demonstrates favorable biofilm removal capabilities, low hemolysis, and acceptable mammalian cell toxicity [1].Formula:C25H30FN2NaO5Color and Shape:SolidMolecular weight:480.5LpxA-IN-1
CAS:LpxA-IN-1, a novel UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitor exhibiting potent activity (IC 50 2 nM), effectively targets Pseudomonas aeruginosaFormula:C21H11D7F3N5O3Color and Shape:SolidMolecular weight:452.44Antimicrobial agent-29
CAS:Antimicrobial Agent-29 (Compound C35) influences the interaction between human hemoglobin and the Staphylococcus aureus IsdB hemophore. This compound facilitates the identification of IsdB:Hb PPI inhibitors [1].Formula:C19H14N4O4SColor and Shape:SolidMolecular weight:394.4Metallo-β-lactamase-IN-14
CAS:Metallo-β-lactamase-IN-14 (Compound 17e) serves as an inhibitor of Metallo-β-Lactamase, displaying inhibitory activity against VIM-1 and VIM-2. This compound also exhibits antibacterial effects on Gram-negative (GN) bacteria and P. aeruginosa [1].Formula:C20H22N8O2S2Color and Shape:SolidMolecular weight:470.57Antibacterial agent 172
CAS:Antibacterial Agent 172 (Compound 6a), a Clostridioides difficile (Cd) SpoVD inhibitor with an IC50 value of 89 nM, effectively inhibits the sporulation of Clostridioides difficile. It is useful for research on bacterial infections [1].Formula:C21H21N9O5S2Color and Shape:SolidMolecular weight:543.58844-TFM
844-TFM, a NBTI DNA gyrase blocker, IC50: 1.5 μM, kills Mycobacterium abscessus.Formula:C24H25F3N4O2Color and Shape:SolidMolecular weight:458.48OPC-167832
CAS:OPC-167832: oral dprE1 inhibitor, IC50 0.258 μM, anti-tuberculosis, for Mycobacterium tuberculosis research.Formula:C21H20ClF3N2O4Color and Shape:SolidMolecular weight:456.84Antifungal agent 27
Antifungal agent 27 shows moderate action against MRSA, weak against C. albicans, with MICs of 8 μg/mL and 32 μg/mL, respectively.Formula:C18H23N5OSColor and Shape:SolidMolecular weight:357.47Antibacterial agent 88
Antibacterial agent 88 is an effective antibacterial agent against B. subtilis (MIC: 4 μg/ml) with MIC values of ≤0.0156 μg/mL for MRSA, MRSE and S. aureus.Formula:C31H44N2O6SColor and Shape:SolidMolecular weight:572.76Antitubercular agent-16
Compound 5q is a potent antitubercular with low MIC90 values (0.40-23.51 μg/mL) against M. tuberculosis strains, showing minimal cytotoxicity.Formula:C21H27N3SColor and Shape:SolidMolecular weight:353.52Elongation factor P-IN-2
Elongation factor P-IN-2, a β-lysine derivative, is a potent EFP inhibitor reducing E. coli growth.Formula:C16H35N3O2Color and Shape:SolidMolecular weight:301.47VEGFR-2/DHFR-IN-2
VEGFR-2/DHFR-IN-2 inhibits VEGFR-2 & DHFR (IC50: 0.623 & 9.085 μM), toxic to C26, HepG2, MCF7 cells (IC50: 3.59-8.38 μM), promising for cancer study.Formula:C21H21NO4Color and Shape:SolidMolecular weight:351.4Rubropunctatin
CAS:Rubropunctatin is a monascus pigment with very potent cancer cell proliferation inhibitory effects.Formula:C21H23NO4Color and Shape:SolidMolecular weight:353.41RmlA-IN-2
RmlA-IN-2: Strong RmlA blocker, hinders l-rhamnose synthesis & alters bacterial wall permeability (IC50: 0.303 μM).Formula:C22H26BrN5O4SColor and Shape:SolidMolecular weight:536.44Antibacterial agent 118
Antibacterial agent 118, potent against various mycobacteria, has MIC values ranging from 10.2 to 163.0 μM. Useful in TB research.Formula:C19H21N5O2SColor and Shape:SolidMolecular weight:383.47LpxC-IN-10
CAS:LpxC-IN-10 is a selective LpxC inhibitor with an MIC of 0.5 μg/mL against E. coli and K. pneumoniae and is capable of being used to study bacterial infections.Formula:C30H31N5O3Color and Shape:SolidMolecular weight:509.6LasR-IN-3
LasR-IN-3 inhibits LasR in Pseudomonas, disrupting its dimer, causing loss of function.Formula:C22H19N3O2Color and Shape:SolidMolecular weight:357.41PqsR-IN-2
PqsR-IN-2, potent PqsR inhibitor, curbs Pseudomonas aeruginosa communication, reduces pyocyanin, with low toxicity.Formula:C18H20ClN3OSColor and Shape:SolidMolecular weight:361.89FG-2101
CAS:FG-2101 is a selective, orally active non-hydroxamate LpxC inhibitor with an IC50 of approximately 1 nM. It demonstrates exceptional selectivity over other bacterial and human metalloproteases. FG-2101 is useful for studying infections caused by Gram-negative bacteria, including resistant strains.Formula:C30H32N5O6PColor and Shape:SolidMolecular weight:589.579Antibacterial agent 77
Antibacterial agent 77 (compound 12) is an antibacterial agent [1].Formula:C22H27N3OSColor and Shape:SolidMolecular weight:381.53GSK-3036656 free base
CAS:GSK656 (GSK3036656) inhibits Mtb LeuRS with IC50 of 0.20 μM, promising for tuberculosis treatment.Formula:C10H13BClNO4Color and Shape:SolidMolecular weight:257.48PptT-IN-3
PptT-IN-3 (5p), an inhibitor of PptT in Mycobacterium tuberculosis, IC50=3.5μM, is key for TB research.Formula:C16H27N5O3SColor and Shape:SolidMolecular weight:369.48RhlR antagonist 1
RhlR antagonist 1: IC50 of 26 μM, selective for RhlR, inhibits P. aeruginosa biofilm and virulence factors.Formula:C12H10F2OColor and Shape:SolidMolecular weight:208.2Antitubercular agent-11
Antitubercular agent-11 (Compound 1e) is an antitubercular agent with a bulkier electron-donating group (Bu-t) that shows the best MIC value of 0.060 μg/mL [1].Formula:C16H15N3O4Color and Shape:SolidMolecular weight:313.31MtTMPK-IN-2
CAS:MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).Formula:C23H24ClN3O3Color and Shape:SolidMolecular weight:425.91NFC nitro probe 1
CAS:NFC nitro probe 1 (compound 18) is a chemical probe designed for the detection of Mtb, exhibiting high potency against both R-Mtb and NR-Mtb.Formula:C19H19NO6Color and Shape:SolidMolecular weight:357.357Probenecid sodium
CAS:Probenecid sodium is the sodium salt of Probenecid, a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Additionally, Probenecid acts as an inhibitor of pannexin 1 channels.Formula:C13H18NNaO4SColor and Shape:SolidMolecular weight:307.341
