Antibacterial
Antibacterial inhibitors are compounds that target bacterial cells, inhibiting their growth or killing them outright. These inhibitors are essential in the development of treatments for bacterial infections and are widely used in research to study bacterial physiology, resistance mechanisms, and the efficacy of new antibacterial agents. At CymitQuimica, we offer a range of antibacterial inhibitors to support your research in microbiology, infectious diseases, and drug development.
Found 3695 products of "Antibacterial"
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BAR-072
CAS:BAR-072 is a small molecule inhibitor targeting TraE with a KD value of 2.7 µM. It significantly suppresses the transfer of the antibiotic resistance-associated plasmid pKM101. BAR-072 holds promise as a candidate molecule for research in disease areas related to infection and resistance control, by inhibiting the spread of bacterial resistance genes.Formula:C18H13N3O6Color and Shape:SolidMolecular weight:367.312Antibacterial agent 76
Antibacterial agent 76 (compound 9) is a potent antibacterial agent.Formula:C23H27N3O2SColor and Shape:SolidMolecular weight:409.54Urease-IN-16
CAS:Urease-IN-16, with an IC50 of 132 µmol/L, is a urease inhibitor that coordinates with nickel atoms through the oxygen atoms of either carbonyl or boronic acid groups. This compound holds significant potential as an additive in the development of efficient fertilizers and medical applications.Formula:C14H17BN2O4SColor and Shape:SolidMolecular weight:320.17BWC0977
CAS:BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Formula:C22H21FN6O5Color and Shape:SolidMolecular weight:468.44FtsZ-IN-13
CAS:FtsZ-IN-13 (Compound C11) functions as an inhibitor of the temperature-sensitive mutant Z (FtsZ), exhibiting IC50 values of 47.97 μM for FtsZSa and 34 μM for FtsZPa. It demonstrates notable antibacterial activity against Staphylococcus aureus (with a minimum inhibitory concentration of 2 μg/mL), cystic fibrosis Staphylococcus aureus clinical isolates, and methicillin-resistant Staphylococcus aureus (MRSA). FtsZ-IN-13 is applicable in research on antibiotic resistance.Formula:C18H14N2O4S2Color and Shape:SolidMolecular weight:386.445O-1269
CAS:O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.Formula:C22H22Cl3N3OColor and Shape:SolidMolecular weight:450.79PqsR-IN-1
PqsR-IN-1, potent PqsR inhibitor, curbs pyocyanin in Pseudomonas aeruginosa with low cytotoxicity.Formula:C17H18ClN3OSColor and Shape:SolidMolecular weight:347.86Antibacterial agent 172
CAS:Antibacterial Agent 172 (Compound 6a), a Clostridioides difficile (Cd) SpoVD inhibitor with an IC50 value of 89 nM, effectively inhibits the sporulation of Clostridioides difficile. It is useful for research on bacterial infections [1].Formula:C21H21N9O5S2Color and Shape:SolidMolecular weight:543.58Colistin adjuvant-2
Colistin adjuvant-2 is a compound that acts as a potentiation agent for colistin, effectively enhancing its activity against Gram-negative bacteria [1].Formula:C14H7Cl2F3N2OColor and Shape:SolidMolecular weight:347.12Antitubercular agent-22
Antitubercular agent-22 combats Candida albicans (MIC: 2.34 μg/ml) and M. tuberculosis (MIC: 2 μg/ml).Formula:C24H28FN5O8Color and Shape:SolidMolecular weight:533.51Mycobacterium Tuberculosis-IN-6
CAS:Mycobacterium Tuberculosis-IN-6 (compound b1) is an inhibitor of the enoyl reductase InhA from Mycobacterium tuberculosis, with an IC50 value of 7.74 μM. It is useful in antibacterial research.Formula:C19H20FNOColor and Shape:SolidMolecular weight:297.367epi-D-Captopril
CAS:epi-D-Captopril (epi-D-SQ 14225) is a stereoisomer of Captopril and functions as an inhibitor of metallo-beta-lactamases (MBLs). The IC50 values of epi-D-Captopril for NDM-1, IMP-1, and VIM-2 are 64 μM, 173 μM, and 5.5 μM, respectively. This compound holds potential for research in MBLs-related antibiotic-resistant infections.Formula:C9H15NO3SColor and Shape:SolidMolecular weight:217.285844-TFM
844-TFM, a NBTI DNA gyrase blocker, IC50: 1.5 μM, kills Mycobacterium abscessus.Formula:C24H25F3N4O2Color and Shape:SolidMolecular weight:458.48Antibacterial agent 78
Antibacterial agent 78 (compound 30) is an antibacterial agent with improved cytotoxicity profile[1].Formula:C16H23N3S2Color and Shape:SolidMolecular weight:321.5Squalamine lactate
CAS:Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity.Formula:C37H71N3O8SPurity:98%Color and Shape:SolidMolecular weight:718.04Urease-IN-1
Urease -IN-1 is a urease inhibitor (IC50: 2.21±0.45 μM).Formula:C17H12BrFN4O2SColor and Shape:SolidMolecular weight:435.27Aeroplysinin 1
CAS:Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation.Formula:C9H9Br2NO3Color and Shape:SolidMolecular weight:338.98Antibacterial agent 110
Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).Formula:C22H21N5O4SColor and Shape:SolidMolecular weight:451.5MtMetAP1-IN-1
MtMetAP1-IN-1 is an inhibitor of methionine aminopeptidase 1 ( MetAP1 ). MtMetAP1-IN-1 shows antimycobacterial activity.Formula:C15H10BrN5O2SColor and Shape:SolidMolecular weight:404.24GT-055
GT-055 (LCB18-055) is a novel inhibitor of broad-spectrum β-lactamase.Formula:C13H20F3N5O8SColor and Shape:SolidMolecular weight:463.39OPC-167832
CAS:OPC-167832: oral dprE1 inhibitor, IC50 0.258 μM, anti-tuberculosis, for Mycobacterium tuberculosis research.Formula:C21H20ClF3N2O4Color and Shape:SolidMolecular weight:456.84Finafloxacin
CAS:Finafloxacin is a pH-activated fluoroquinolone, most effective at pH 5.0-6.0, targeting bacterial topoisomerases, used for UTIs and H. pylori infections.Formula:C20H19FN4O4Color and Shape:SolidMolecular weight:398.39Glutamate-5-kinase-IN-2
Glutamate-5-kinase-IN-2 (compound 54) is a potent G5K inhibitor with 4.2 μM MIC, potential in anti-TB research.Formula:C17H10ClFN2Color and Shape:SolidMolecular weight:296.73MetRS-IN-1
CAS:MetRS-IN-1 (Compound 27) is an inhibitor of E. coli methionyl-tRNA synthetase (MetRS) with an IC50 value of 237 nM [1].Formula:C15H13N3O4SColor and Shape:SolidMolecular weight:331.354-Hexen-3-one
CAS:4-Hexen-3-one inhibits the growth of H. pylori in the ATCC 43526 strain and TDR strain. Additionally, this compound suppresses urease activity.Formula:C6H10OColor and Shape:SolidMolecular weight:98.14Rf470 TFA
CAS:Rf470 (Rotor NO.4) TFA is an FMR-probe-D-lysine conjugate (Max Ex: 470 nM; Max Em: 640 nM) that can be covalently integrated into bacterial peptidoglycan. In its free state, Rf470 TFA exhibits weak fluorescence, which significantly increases upon integration into peptidoglycan by transpeptidase catalysis. This fluorescence change allows Rf470 TFA to be used for real-time monitoring of peptidoglycan biosynthesis, detecting transpeptidase activity, and screening antibiotics.Formula:C28H31F3N4O7SColor and Shape:SolidMolecular weight:624.63(R)-ZG197
(R)-ZG197: Activates Sa ClpP (EC50=1.5μM) & Hs ClpP (EC50=31.4μM); selective for Sa ClpP.Formula:C28H35F3N4O3Color and Shape:SolidMolecular weight:532.6Antitubercular agent-23
Antitubercular agent-23 combats Candida albicans (MIC: 1.1 μg/ml) and M. tuberculosis (MIC: 1 μg/ml).Formula:C20H22FN5O8SColor and Shape:SolidMolecular weight:511.48FtsZ-IN-4
FtsZ-IN-4 is an oral FtsZ inhibitor with strong antibacterial effects and good drug traits, low toxicity (CC50 >20μg/mL).Formula:C21H16ClF2NO2Color and Shape:SolidMolecular weight:387.81MBX-1162
CAS:MBX-1162, a bis-indole compound, has demonstrated unique substrate specificity related to MepA and MepR in studies investigating its resistance mechanisms in Staphylococcus aureus. It has not shown cross-resistance with related compounds.Formula:C30H28N6Color and Shape:SolidMolecular weight:472.58MtTMPK-IN-3
CAS:MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.Formula:C23H23Cl2N3O3Color and Shape:SolidMolecular weight:460.35Antibacterial agent 75
Antibacterial agent 75 re-sensitizes VRSA to vancomycin.Formula:C22H28N6OColor and Shape:SolidMolecular weight:392.5ACHN-975 TFA
CAS:ACHN-975 TFA is a selective inhibitor of the bacterial enzyme LpxC, antimicrobial against multiple Gram-negative bacteria.Formula:C22H24F3N3O6Purity:99.57%Color and Shape:SolidMolecular weight:483.448-Hydroxyerythromycin A
CAS:8-Hydroxyerythromycin A is a semi-synthetic antibiotic with antibacterial activity.Formula:C37H67NO14Color and Shape:SolidMolecular weight:749.926Cephalosporin C
CAS:Cephalosporin C exhibits relatively weak resistance to Gram-positive and Gram-negative bacteria. It is stable against penicillinase, but can be decomposed by cephalosporinase. When hydrolyzed to remove its side chain, it yields 7-amino-cefenoic acid (7-ACA), which is an essential raw material for the production of semisynthetic cephalosporins.Formula:C16H21N3O8SColor and Shape:SolidMolecular weight:415.418Antimicrobial agent-38
CAS:Antimicrobial agent-38 (compound 10) effectively inhibits methicillin-resistant Staphylococcus aureus (S. aureus) strain ATCC 700699 and non-resistant strain ATCC 29213, with minimum inhibitory concentrations (MIC) of 32 mg/L and 64 mg/L, respectively.Formula:C14H11N3O4SColor and Shape:SolidMolecular weight:317.32VEGFR-2/DHFR-IN-1
Compound 8b inhibits VEGFR-2/DHFR, combats various bacteria, and fights cancer cells.Formula:C20H18ClNO4Color and Shape:SolidMolecular weight:371.81Antitubercular agent-11
Antitubercular agent-11 (Compound 1e) is an antitubercular agent with a bulkier electron-donating group (Bu-t) that shows the best MIC value of 0.060 μg/mL [1].Formula:C16H15N3O4Color and Shape:SolidMolecular weight:313.31Antitubercular agent-15
Antitubercular agent-15 (5n): low toxicity, fights M. tuberculosis strains; MIC90 values range 0.73-18.8 μg/mL.Formula:C21H29FN2Color and Shape:SolidMolecular weight:328.47MraY-IN-2
MraY-IN-2 (compound 6) is an effective inhibitor of bacterial transposase MraY (IC50=4.5 μ M), and can be used for antibacterial research.Formula:C16H23N3O9Color and Shape:SolidMolecular weight:401.37Antibacterial agent 174
CAS:Compound 174 (Compound 5g), an antibacterial agent, exhibits potent anti-infective properties in vivo along with appreciable pharmacokinetic profiles. This highly active substance demonstrates favorable biofilm removal capabilities, low hemolysis, and acceptable mammalian cell toxicity [1].Formula:C25H30FN2NaO5Color and Shape:SolidMolecular weight:480.5Antibacterial agent 236
CAS:Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.Formula:C26H27N5O2SColor and Shape:SolidMolecular weight:473.59Thiolactomycin
CAS:Thiolactomycin is a novel reversible dual inhibitor of D-amino acid oxidase (DAO) and D-Aspartate oxidase (DDO).Formula:C11H14O2SPurity:98%Color and Shape:SolidMolecular weight:210.29G092
G092 is a potent inhibitor of MsbA. MsbA is an ABC transporter protein. G092 has potential for antibacterial drug research.Formula:C23H20Cl2N2O3Color and Shape:SolidMolecular weight:443.32MtTMPK-IN-2
CAS:MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).Formula:C23H24ClN3O3Color and Shape:SolidMolecular weight:425.91PCTR1
CAS:PCTR1, derived from DHA, hastens inflammation resolution and boosts macrophage function, reducing PGE2, PGD2, and TXB2 in mice.Formula:C32H47N3O9SColor and Shape:SolidMolecular weight:649.8Lambertellin
CAS:Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.Formula:C14H8O5Color and Shape:SolidMolecular weight:256.21Penethamate hydriodide
CAS:Penethamate hydriodide is a diethylaminoethyl ester prodrug of penicillin, utilized via intramuscular injection to treat mastitis in cattle.Formula:C22H32IN3O4SColor and Shape:SolidMolecular weight:561.477LpxA-IN-1
CAS:LpxA-IN-1, a novel UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitor exhibiting potent activity (IC 50 2 nM), effectively targets Pseudomonas aeruginosaFormula:C21H11D7F3N5O3Color and Shape:SolidMolecular weight:452.44Antibiotic U 44590
CAS:5,6-Dihydro-5-azathymidine exhibits activity against both Gram-positive and Gram-negative bacteria, as well as DNA viruses.Formula:C9H15N3O5Color and Shape:SolidMolecular weight:245.23
