Antibacterial

Cloflucarban can be used as a disinfectant agent.

ML267 (4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate) is a potent inhibitor of bacterial

DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.

NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.

Antibiotic botryodiplodin from Botryodiplodia has anti-leukemia effects, turns skin pink in 2-3 hrs, and comes from Penicillium carneo-lutescens.

Zifanocycline (KBP-7072) TFA is a semi-synthetic aminomethylcycline antibiotic with oral bioavailability, targeting bacterial ribosomes to impede their function

Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.

A 26771B is an antibiotic in the class of macrolide lactone.

BMS 180680 is a novel catechol-containing monolactam antibacterial active agent, which is the most effective compound against many species of Enterobacteriaceae

Cephaloridine hydrate, a broad-spectrum antibacterial antibiotic, exhibits dose-related nephrotoxicity [1] [2].

Pomolic Acid 3-Acetate, an antitubercular compound, exhibits a minimum inhibitory concentration (MIC) of 32 μM against Mycobacterium tuberculosis H37Rv [1].

Cyclothialidine is an inhibitor of DNA gyrase.

Ceftaroline: a cephalosporin antibiotic effective against MRSA, drug-resistant S. pneumoniae, and Gram-negatives; used for cSSSIs and CABP research.

Kyotorphin is a Morphine-like dipeptide.

Demethyl linezolid, an impurity in linezolid (WO199500721A1, ex. 9), has antimicrobial effects on human and veterinary pathogens.

Daunosamnyl-daunorubicin is used as an antibody conjugate.

Thiomarinol A: potent antibiotic, dithiolopyrrolone-marinolic acid hybrid with MRSA-targeting antimicrobial activity; inhibits IleRS, Ki app 19 nM.

KU13 is an inhibitor of non-tuberculous mycobacteria (NTM), demonstrating minimum inhibitory concentrations (MIC) of 0.032-8 μg/mL against Mycobacterium and 2 μg/mL against E. coli. It is applicable in research focused on anti-infective treatments.

Amicetin, a potent antibiotic, is effective against gram-positive bacteria by inhibiting protein synthesis [1] [2] [3].

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.