Organometallic Ligands

<p>HMG-CoA reductase antagonist</p>

<p>MEDICA16: GPR40 agonist, GPR120 partial agonist, ATP-citrate lyase inhibitor, lowers TG, boosts insulin sensitivity in muscle.</p>

<p>Vasopressin receptor agonist; antidiuretic</p>

<p>UK 383367 is a chemical compound classified as a synthetic small molecule, which is derived from a meticulously controlled chemical synthesis process. Its mode of action involves modulating specific biochemical pathways by binding to target receptors, thereby influencing cellular processes at a molecular level. This compound is utilized extensively in pharmaceutical research for its potential therapeutic effects, particularly in the context of investigating receptor activity and signaling pathways. Additionally, UK 383367 finds applications in various industrial processes, serving as an intermediate in the synthesis of more complex compounds. Due to its precision in targeting and influencing biological systems, UK 383367 is a valuable tool for scientists seeking to elucidate the mechanistic pathways underlying disease and for the development of novel therapeutic strategies.</p>

<p>2-Benzyl-2,8-diazaspiro[4.5]decan-1-one hydrochloride is a chemical compound utilized chiefly in pharmacological research. It is synthesized through organic chemical processes designed to produce spirocyclic frameworks that can interact specifically with biological macromolecules. The compound acts as a ligand in receptor studies, allowing researchers to investigate the binding properties and activities at selective receptor subtypes.</p>

<p>Alprostadil alfadex is a medicinal drug that has been found to have anticancer properties. It works by inhibiting the growth of cancer cells and inducing apoptosis, or programmed cell death. This drug is an analog of a naturally occurring protein that acts as a tumor inhibitor in humans. Alprostadil alfadex has been shown to be effective against various types of cancer, including those found in the urinary tract and prostate. It works by blocking the action of certain enzymes and proteins involved in the cell cycle, thereby preventing cancer cells from dividing and multiplying. Chinese researchers have also found that this drug has a kinase-inhibiting effect, which may contribute to its anticancer activity.</p>

<p>ROPA or resiniferonol 9,13,14-orthophenylacetate is an analogue of resiniferatoxin that has been shown to have synergistic interactions with detergents, such as Tween-80, in the removal of wheat germ agglutinin (WGA) from Brucella. ROPA is also active against herpes simplex virus and tumour necrosis factor-alpha (TNF-α). When combined with a basic protein, it can activate the receptor and inhibits the formation of dry weight. ROPA has been shown to be able to inhibit the growth of infectious bacteria, such as those that cause tuberculosis or brucellosis. The mechanism for this inhibition is not clear, but may be due to its ability to bind to water molecules and inhibit their binding with bacterial cytoplasmic membranes.</p>

<p>PI3K-gamma inhibitor 1 is a small molecule inhibitor, which is selectively synthesized for targeting the PI3K-gamma isoform. This inhibitor is derived through precise medicinal chemistry, involving the synthesis of compounds that specifically interact with the catalytic domain of the phosphoinositide 3-kinase gamma (PI3K-γ) enzyme. Its mode of action involves the selective inhibition of the PI3K-γ pathway, a critical signaling route responsible for modulating immune cell functions and inflammatory responses.</p>

<p>ALX-1393 is a synthetic compound that acts as an inhibitor, specifically targeting the glycine transporter 1 (GlyT1). As a small molecule inhibitor derived from chemical synthesis, it modulates neurotransmitter systems by blocking the reuptake of glycine, an important co-agonist of the NMDA receptor, in the central nervous system. The mode of action of ALX-1393 involves binding to the GlyT1 transporter, thereby increasing the synaptic concentration of glycine. This elevation in glycine levels enhances NMDA receptor function, which is crucial for synaptic plasticity, learning, and memory.</p>

<p>UM729 is an advanced surface coating, which is a chemical formulation with the aim of enhancing surface durability and protection. Sourced from novel polymeric materials, UM729 is designed to form a robust and resilient layer when applied to various substrates. Its mode of action involves cross-linking at the molecular level, creating a cohesive barrier that offers resistance to environmental factors such as abrasion, moisture, and UV radiation.</p>

<p>FAPI-46 trifluoroacetate is a fibroblast activation protein (FAP) inhibitor, which is synthesized as part of targeted cancer research efforts. It is derived from chemical engineering processes focusing on the modification of small molecules to selectively interact with FAP, an enzyme overexpressed in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. FAPI-46 binds to and inhibits FAP, reducing its enzymatic activity. By blocking FAP, FAPI-46 trifluoroacetate disrupts the tumor-promoting interactions between CAFs and tumor cells, potentially impeding tumor growth and progression.</p>

<p>μ- and κ- opioid receptor antagonist; partial agonist of δ- opioid receptors</p>

<p>Benzoic acid 5-amino-1-(4-methoxy-benzenesulfonyl)-1H-pyrazol-3-yl ester is a synthetic chemical compound used primarily in advanced organic synthesis. It is derived from benzoic acid and functionalized with a pyrazole moiety, enhancing its reactivity and versatility in chemical transformations. This compound acts as an intermediate in the synthesis of more complex molecules, playing a crucial role as a precursor or reagent due to its unique structure, which facilitates targeted chemical modifications.</p>

<p>VS1 is a novel synthetic peptide, which is engineered to function as an antimicrobial agent. This peptide originates from recombinant DNA technology, providing a customizable approach to target specific microbial strains. Its mode of action involves the selective disruption of microbial cell membranes, leading to the lysis and consequent death of the target cell. The specificity of VS1 for microbial cells over mammalian cells minimizes off-target effects, making it a highly effective agent for infection control.</p>

<p>L-MobileTrex is an advanced analytical technology platform, which is a product of cutting-edge research in data science and computational modeling. This platform operates by integrating multi-dimensional datasets through sophisticated algorithms, providing enhanced data visualization and interpretability.</p>

<p>A negative allosteric modulator of Flt-3 receptor tyrosine kinase</p>

<p>Osmanthuside H is a natural compound, specifically a phenylethanoid glycoside, which is predominantly sourced from the plant Osmanthus fragrans, as well as other related species. This compound is characterized by a specific glycosidic linkage that contributes to its stability and bioactivity. The mode of action of Osmanthuside H primarily involves its significant antioxidant properties, attributed to the presence of its phenolic structure and glycosidic moiety. This facilitates its role in scavenging free radicals and reducing oxidative stress within biological systems.</p>

<p>CAY10727 is a potent biochemical inhibitor, which is derived from synthetic sources with specific action targeting cyclooxygenase-2 (COX-2) enzymes. It functions by selectively blocking the enzymatic activity of COX-2, which plays a critical role in the biosynthesis of prostaglandins involved in inflammatory responses. This targeted inhibition allows the study of COX-2-related pathways without interference from COX-1, which is significant for maintaining gastrointestinal integrity.The use and applications of CAY10727 are primarily in research settings where understanding the pathways involved in inflammation, pain, and cancer progression are critical. This compound is utilized in various in vitro experiments to delineate the role of COX-2 in cellular and molecular contexts, enabling scientists to dissect complex signaling networks. Given its specificity, CAY10727 is instrumental in the development of new therapeutic approaches where selective COX-2 inhibition might offer benefits over non-selective inhibitors.</p>

<p>1,2-Dipalmitoyl-3-dimethylammonium-propane is a cationic lipid, which is a type of synthetic lipid commonly used in biochemical and biophysical research. It is sourced from chemical synthesis, involving the formulation of lipid molecules with specific chemical modifications to confer particular properties. The mode of action of this compound involves its ability to integrate into lipid bilayers and form liposomes. These liposomes can encapsulate nucleic acids, facilitating their delivery into cells by merging with cell membranes, which is crucial for gene delivery applications.</p>

<p>N-(5-Aminopentyl) methotrexate amide-LC-biotin is a specialized bioconjugate, derived through the conjugation of methotrexate, an established antifolate drug, with an LC-biotin moiety. This product is synthesized by covalently linking methotrexate, which is known for its role in cancer therapy through the inhibition of dihydrofolate reductase (DHFR), to a biotin moiety via a long-chain spacer. The resultant bioconjugate retains the therapeutic effects of methotrexate, particularly in its ability to interrupt nucleotide synthesis, thereby affecting cell division in rapidly proliferating cancer cells.The inclusion of biotin in the structure allows for facile attachment to avidin or streptavidin-labeled systems, facilitating targeted delivery and enhanced detection in molecular and cellular studies. The primary application of N-(5-Aminopentyl) methotrexate amide-LC-biotin lies in the realm of targeted drug delivery and advanced research into methotrexate metabolism. By leveraging the high affinity of biotin-streptavidin interactions, researchers can effectively study the biodistribution and cellular uptake of methotrexate, advancing cancer therapeutic strategies and providing insights into antifolate drug mechanisms at the molecular level.</p>

<p>Alvameline is a muscarinic receptor agonist, which is a small molecule drug derived from synthetic chemistry processes. Its primary source is the intricate design of pharmacologically active compounds targeting the central nervous system. Alvameline exerts its effects through selective agonism of muscarinic acetylcholine receptors, playing a pivotal role in modulating neurotransmission. Specifically, by activating these receptors, it enhances cholinergic signaling, which is crucial for cognitive functions such as memory and attention.</p>

<p>A novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors</p>

<p>Foslevodopa is a prodrug that is converted to levodopa in the body. This drug has been shown to be safe and effective for the treatment of Parkinson's disease with minimal side effects, although it does not affect the progression of the disease. Foslevodopa is a synthetic compound that has been synthesized using chemical methods. It can be manufactured in large quantities, making it a scalable pharmaceutical formulation.</p>

<p>BCR-ABL-IN-2 is a small molecule inhibitor, which is synthetically derived for precision-targeted therapeutic applications. It functions as a selective inhibitor of the BCR-ABL fusion protein, a tyrosine kinase that is constitutively active in certain leukemias, particularly chronic myeloid leukemia (CML). The product is engineered via chemical synthesis to ensure high specificity and selectivity in binding to the ATP-binding site of the BCR-ABL protein, effectively inhibiting its kinase activity.</p>

<p>PF-06658607 is an investigational drug that is classified as a small molecule inhibitor. It is developed from synthetic chemical sources with a specific mode of action targeting aggrecanases, enzymes that degrade aggrecan, a critical component of cartilage. By inhibiting these enzymes, PF-06658607 aims to prevent the breakdown of cartilage in joints.</p>

<p>FR-190809 is a peptide that acts as an inhibitor of protein interactions. It binds to the receptor and blocks the activation of phospholipase C. FR-190809 also stimulates the production of cyclic AMP, which in turn activates protein kinase A, thereby inhibiting the production of cAMP. FR-190809 has been shown to have a high purity and is used as a research tool for studying protein interactions.</p>

<p>CB-1158 is an arginase inhibitor, which is a small molecule derived from a synthetic source designed to modulate immune functions. Its mode of action involves the inhibition of the arginase enzyme, a key player in the urea cycle responsible for the hydrolysis of arginine into ornithine and urea. By blocking arginase, CB-1158 effectively prevents the depletion of extracellular arginine, a vital amino acid required for the activation and proliferation of T cells within the immune system. This inhibition leads to enhanced immune responses against tumors.</p>

<p>Inhibitor of PARP1 and PARP2 enzymes</p>

<p>Trypsin (EC 3.4.21.4) is a protease that hydrolyses proteins by cleaving the peptide bond at the carboxyl side of the positively charged amino acid (Lysine or Arginine). Trypsin belongs to a family of serine proteases, as it has a serine in its active site. Trypsin can be inhibited by using trypsin inhibitor Alpha 1 Antitrypsin.</p>

<p>UM171 is a small-molecule compound, which is derived from synthetic chemical processes with properties that enable the expansion of human hematopoietic stem cells (HSCs) in vitro. It acts by targeting and modulating specific cellular pathways to enhance the self-renewal and proliferation of HSCs without inducing differentiation.<br><br>The primary application of UM171 lies in the field of regenerative medicine and transplantation. By facilitating the expansion of HSCs, UM171 holds significant potential in improving the outcomes of bone marrow and cord blood transplants. This is particularly relevant in contexts where donor cell availability is limited or where augmenting the engraftment potential of HSCs is critical. The ability to expand HSCs ex vivo opens avenues for improved treatment of hematological disorders, potentially allowing for more effective and accessible transplant therapies. Researchers are exploring its utility in diverse experimental setups, aiming to translate this compound's capabilities into clinical settings to enhance patient outcomes in hematopoietic recovery and therapy.</p>

<p>Please enquire for more information about Elafibranor including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>TAPI-1 is an inhibitor of TACE (TNF-α converting enzyme, also known as ADAM17) and matrix metalloproteinases (MMPs). It blocks the shedding of several cell surface proteins, including tumor necrosis factor-alpha (TNF-α), IL-6 receptor, and TNF receptors p60 (TNFRI) and p80 (TNFRII).</p>

<p>SNIPER(ABL)-058 is a cutting-edge selective protein degrader, developed from the field of chemical biology. It is based on a bifunctional small molecule that acts as a degrader by recruiting the ubiquitin-proteasome system to specifically tag the target protein for degradation. This compound is synthesized through precise chemical modifications designed to form specific interactions with its target, namely the BCR-ABL protein, a critical driver in certain cancer pathways.</p>

<p>Mots-C is a mitochondrial-derived peptide, which is encoded by the small open reading frame found within the mitochondrial 12S rRNA. This peptide functions by interacting with the cellular metabolic pathways to enhance mitochondrial bioenergetics and overall cellular metabolism. Mechanistically, Mots-C modulates the folate–methionine cycle, directly impacting glucose regulation and energy utilization, and consequently facilitating cellular adaptation to metabolic stress.</p>

<p>SLV-2436 is a highly specialized laboratory reagent, which is synthetically derived through an advanced chemical process with rigorous quality control. Its mode of action involves precise interactions at a molecular level, facilitating targeted reactions and transformations essential for a variety of analytical and research applications.</p>

<p>(4bS,8aS,9S,10S)-10-(Acetyloxy)-3,9-bis(benzoyloxy)-4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-1,4-phenanthrene dione is a potent chemokine molecule that is an agonist of the CXCR2 receptor. It has been shown to inhibit cancer stem cells and chemoattractant production in colon carcinoma cells. This compound selectively targets the translation of lamiaceae mRNA and induces apoptosis in colon carcinoma cells.</p>

<p>D-Threonic acid lithium salt is a cell signaling molecule that belongs to the class of ligands. It has been used as a research tool in pharmacology and protein interaction studies. D-Threonic acid lithium salt can activate ion channels, which are cellular membrane proteins that allow ions to flow in or out of cells. D-Threonic acid lithium salt also interacts with receptors, which are proteins on the surface of cells that receive chemical signals from outside the cells. Receptors can be either agonists or antagonists. D-Threonic acid lithium salt is a ligand for receptor tyrosine kinase, which is involved in cell growth and differentiation.</p>