Other Inhibitors

<p>Alnusonol is a natural product for research related to life sciences. The catalog number is TN5691 and the CAS number is 52330-12-8.</p>

<p>OVA-PEG-Cy3 is a conjugate of OVA-PEG labeled with Cy3. The Cy3 fluorophore is widely used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry, with its maximum emission wavelength approximately at 562-570 nm. Ovalbumins (OVA) are the primary proteins found in egg whites, known for their diverse biological activities, including anticancer, antihypertensive, antibacterial, antioxidant, and immunoregulatory effects. Ovalbumins are the most abundant proteins synthesized in oviducts treated with progesterone or estrogen and are commonly used as markers to study hormone regulation of gene expression in tissues.</p>

Biotin-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

N2-Capryloyl lysine is a bioactive chemical.

<p>Bexmarilimab (FP-1305) is a highly potent humanized anti-CLEVER-1 IgG4 antibody with an IC50 value of 4.51 nM.</p>

Ametryn is a methylthiotriazine based herbicide. Ametryn inhibits photosynthesis and other enzymatic processes.

Chiirirhamnin is a natural product that can be used as a reference standard.

<p>N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based linker for PROTAC synthesis.</p>

Taikuguasin D is a natural product for research related to life sciences. The catalog number is TN6242 and the CAS number is 1627163-80-7.

1-(t-Boc-Aminooxy)-3-aminooxy-propane is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs[1].

<p>1-Ethoxycarbonyl-β-carboline is a natural product for research related to life sciences. The catalog number is TN7072 and the CAS number is 72755-19-2.</p>

Tetraethyl butane-1,4-diylbis(phosphonate) is an alkyl chain-derived linker for PROTACs synthesis[1].

<p>cRGD-PEG-Cy3 is a cRGD-PEG conjugate labeled with Cy3. The Cy3 fluorophore is commonly utilized in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry, with a peak emission wavelength of approximately 562-570 nm. cRGD can be used for lipid modification to enhance stability.</p>

C.I. 59830 is a green dye.

Asperlin is an orally active marine-derived antibiotic with antifungal, anticancer, anti-inflammatory, and anti-atherosclerotic properties. It can induce apoptosis and increase reactive oxygen species (ROS) and DNA damage-related G2/M phase arrest, as well as ATM phosphorylation. Additionally, Asperlin effectively prevents HFD-induced obesity in vivo and modulates gut microbiota.

<p>P-ESBP-DOX is an HPMA copolymer-drug conjugate composed of an E-selectin binding peptide and Doxorubicin. It exhibits cytotoxicity against TNFα-activated human vascular endothelial cells (IVEC) with an IC50 of 0.28 μM and is useful for tumor vasculature research.</p>

(S)-TCO-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

<p>Stachybotrylactam has toxicity.</p>

BTNPO is a unimolecular two-photon fluorescent probe.

Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption.

<p>3-hydroxy steroid derivative used in chemistry and life sciences research.</p>

<p>BTD probe-1 is a benzothiazine-based chemical selective probe used for the in vitro specific labeling of protein S-sulfinic acid. It selectively modifies sulfinic acid residues within proteins.</p>

Azido-PEG6-C1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

<p>Alexa Fluor 430 NHS ester is a compound used to conjugate the green fluorescent dye Alexa Fluor 430 with proteins or antibodies. Alexa Fluor 430 provides stable signal generation in imaging and flow cytometry. The NHS ester is suitable for labeling proteins, amine-modified oligonucleotides, and other primary amine-containing molecules (R-NH2).</p>

Mycaminosyltylonolide is a macrolide with a beta-D-mycaminosyl at position 5, potent against bacteria and luciferase synthesis.

m-PEG24-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

<p>CH-0793076 TFA is a camptothecin analog, a major TP300 metabolite, and a Topo I inhibitor with an IC50 of 2.3 μM, effective against BCRP+ cells.</p>

<p>Quisultazine is a phenothiazine derivative with no central effects, can be classified as a non anti H2 antisecretory agent.</p>

<p>5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is an inhibitor of the enzyme phosphodiesterase 10A (PDE10A) with a Ki value of 24 μM. This compound can be employed in research related to schizophrenia.</p>

<p>2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide is a useful organic compound for research related to life sciences.</p>

<p>VH4127 is a cyclic peptide designed to target low-density lipoprotein receptors (LDLR) with a KD of 18 nM for hLDLR. Incorporating non-natural amino acid residues, VH4127 binds specifically to epidermal growth factor (EGF) LDLR homologous domains in both rodents and humans.</p>

<p>1,2-Dihydronaphthalene is a naphthalene derivative widely used in biochemical experiments and drug synthesis research.</p>

2-(Methylamino)benzoic acid, the primary metabolite of methyl-N-methylanthranilates (MMA), results from the conversion of the ester group in MMA.

<p>Karaviloside V is a useful organic compound for research related to life sciences. The catalog number is T123927 and the CAS number is 922192-72-1.</p>

2,3,9,10-Tetrahydroxyberberine is a useful organic compound for research related to life sciences and the catalog number is T125658.

<p>H2S Fluorescent probe 1 (Compound 2) is a fluorescent probe for detecting hydrogen sulfide (H2S) with minimal cytotoxicity. When HS- is added to the DMSO solution of H2S Fluorescent probe 1, a new absorption peak appears at 485 nm. During the titration of HS-, the fluorescence intensity at 434 nm increases rapidly.</p>

Creoside III is a natural product for research related to life sciences. The catalog number is TN5837 and the CAS number is 1038602-12-8.

<p>Ethyl 4-oxopentanoate is a reagent containing both ester and ketone groups, widely used in biochemical experiments and drug synthesis research.</p>

<p>Cyanine 3 Tyramide methyl indole, a derivative of the orange fluorescent dye Cyanine 3 Tyramide, serves as a reporter fluorescent substrate in the horseradish</p>

<p>Arisugacin A is a potent, orally active, and selective inhibitor of acetylcholinesterase (AChE).</p>

Thiol-PEG10-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

<p>Stachartin B is a natural product from the cultures of the tin mine tailings-associated fungus Stachybotrys chartarum.</p>

<p>Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is a mouse γ-type anti-recombinant antibody.</p>

<p>ABBV-4083 is a Tylosin A analog that has potent anti-Wolbachia and anti-filarial activity.</p>

Fluorescein-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

<p>Cicutoxin is a convulsant compound. It inhibits Na+ and K+ channels and suppresses the γ-aminobutyric acid pathway. As a potent GABA antagonist, Cicutoxin induces recurrent seizures and exhibits cholinergic activity. Its primary targets are the brain and skeletal muscles. Cicutoxin can be isolated from [Cicuta maculata] and [Cicuta douglasii].</p>

<p>YARA peptide is a cell-penetrating peptide that acts as an MK2 inhibitor. In vitro skin culture models demonstrate that nanoparticles loaded with YARA reduce levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α). YARA peptide holds potential for research in atopic dermatitis (AD).</p>

<p>Dimerum acid is a dihydroxamate (dihydroxamate) type iron carrier (siderophore) found in Penicillium chrysogenum. It serves as a precursor or degradation product of coprogen and significantly enhances iron uptake in Strategy I plants (such as cucumber) and Strategy II plants (such as maize). At a pH of 6.0, dimerum acid releases bioavailable Fe3+ through ligand exchange with plant-secreted phytosiderophore (phytosiderophore, PS) or EDTA, thereby improving iron supply efficiency in plants. Dimerum acid is applicable in research related to plant iron nutrition and agriculture.</p>

Talisomycin A (Tallysomycin A) is a complex antibiotic with antitumor properties.

(+)-Biotin-PEG10-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

Ajaconine is a useful organic compound for research related to life sciences and the catalog number is TSP-41507048.

<p>Cu(II) Protoporphyrin IX serves as negative control for Zn(II) Protoporphyrin, affecting tumor chemotherapy resistance and inflammation regulation.</p>

Doxercalciferol impurity, synthetic ergocalciferol analog, treats secondary hyperparathyroidism, inhibits parathyroid.

<p>Herbicidal agent 8 (Compound 9w) targets auxin indole-3-acetic acid (IAA), disrupting the physiological activities of plant cells and ultimately causing plant death. Herbicidal agent 8 exhibits herbicidal activity against both broadleaf and grass weeds.</p>

3,4-Dihydroxy-2-methoxyxanthone shows antibacterial, and hepatoprotective activities, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell

Nortanshinone is a natural product isolated from Dan-Shen.

<p>3-Formylcarbazole is a natural product for research related to life sciences. The catalog number is TN6217 and the CAS number is 51761-07-0.</p>

Mal-PEG1-bromide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

<p>Alodan (Nodon) is an organic chloride insecticide.</p>

Leucyl-phenylalanine (H-LEU-PHE-OH) is a dipeptide compound that can be used for protein synthesis.

1,2-Cyclohexanediol is an alcohol compound widely used in biochemical experiments and drug synthesis research.

<p>PhAc-ALGP-Dox is a peptide-drug conjugate and a novel antitumor prodrug. It exhibits a range of IC50 values from 311 nM to 34.25 μM against TNBC (E0771), normal mouse epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human colorectal cancer (LS 174T), and normal human epithelium (HME-1) cells.</p>

N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5, a PEG linker, used in PROTAC synthesis.

<p>SHMT-IN-3 (Hit 1) is an inhibitor of SHMT1 and SHMT2, exhibiting an IC50 value of 0.53 µM for human SHMT1. It acts as a non-competitive inhibitor with respect to serine.</p>

<p>4-Ethyl-1,2-dimethylbenzene is an aromatic hydrocarbon widely used in biochemical experiments and drug synthesis research.</p>

Fmoc-NH-PEG19-CH2CH2COOH is a Polyethylene Glycol (PEG)-based linker for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

(2R)-Glycerol-O-β-D-Galactopyranoside exhibits inhibitory effects on RAJI cells and is widely used in biochemical experiments and drug synthesis research.

N-(Azido-PEG3)-N-Boc-PEG3-acid is a PEG-based linker for PROTACs construction.

(R)-AS-1 is a selective positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2), with an EC50 of 11 nM. At doses of 60 and 90 mg/kg, (R)-AS-1 enhances spontaneous locomotor activity in mice. It demonstrates anticonvulsant properties in mouse seizure models induced by maximal electroshock (MES), pentylenetetrazole (PTZ), or electric current stimulation (32 or 44 mA), with ED50 values of 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively. This compound is applicable in neurological disease research.

Ald-Ph-amido-C2-PEG2-amine is a polyethylene glycol (PEG)-based linker utilized for the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].

4-Cl-3-(CF3)phenyl isocyanate made from o-chlorobenzotrifluoride and acetic anhydride.

<p>Pt(IV)-M13 is a platinum (IV) prodrug conjugated with a perfluoroaryl macrocyclic peptide, capable of crossing the blood-brain barrier. It exhibits cytotoxicity towards glioblastoma stem cells and enhances platinum uptake in the brain, making it a valuable tool for glioblastoma research.</p>

<p>Kanjone is a compound discovered in Millettia peguensis, which can be used in the synthesis of protein tyrosine phosphatase 1B (protein tyrosinephosphatase1B) inhibitors. Kanjone holds potential for research in the fields of diabetes and neurological disorders.</p>

L-Lactic acid-13C3 is a stable isotope labeled L-Lactic acid analog. L-Lactic acid-13C3 can be used for lactate metabolism research.

<p>Andrographolide-lipoic acid is an analogue of Andrographolide, synthesized through the conjugation of Andrographolide and Lipoic acid. It inhibits NF-κB and exhibits anti-diabetic effects as well as protective effects on β-cells.</p>

<p>Tezepelumab (AMG 157) is a humanized monoclonal antibody (IgG2λ) targeting TSLP that prevents TSLP from interacting with its heterodimer receptor.</p>

<p>Adiposin is a microbial metabolite that acts as an inhibitor of α-glucoside hydrolase (α-glucosidase).</p>

<p>SUDAN ORANGE G is a natural product.</p>

Biotin-amido-PEG4-PFP ester is a Polyethylene glycol (PEG)-based PROTAC linker utilized for PROTACs synthesis [1].

<p>Paspalinine blocks ChTX binding to bovine maxi-K channels and inhibits GABAA, causing tremors.</p>

8-Hydroxy-9,10-diisobutyryloxythymol is a natural product for research related to life sciences. The catalog number is TN5862 and the CAS number is 22518-08-7.

<p>Gigantetrocin is a bioactive acetyl coenzyme derived from Goniothalamus giganteus, a plant in the Annonaceae family.</p>

Ligularizine is a natural product that can be used as a reference standard.

5,5'-Dihydroxy-3,8,3',4'-tetramethoxy-6,7-methylenedioxyflavone is a natural product for research related to life sciences.

Deacetylpleionesin C is a natural product for research related to life sciences. The catalog number is TN6161 and the CAS number is 1454585-39-7.

<p>MP 518 is a PDE inhibitor with antihypertensive properties. It prevents the degradation of cAMP, leading to increased ICa levels, and counteracts the effects of β-adrenergic stimulation, resulting in vasodilation.</p>

Dynorphins, opioid peptides from prodynorphin, form upon cleavage by PC2 into dynorphin A, B, and α/β-neo-endorphin.

<p>Neocopiamycin A exhibits broad-spectrum resistance against Gram-positive bacteria, yeast, and filamentous fungi.</p>

meso-Dihydroguaiaretic acid is an LXR-α antagonist, it inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.

<p>4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester, a versatile peptide linker.</p>

<p>3,4,5-Trihydroxyallylbenzene 3,4-di-O-glucoside is a natural product for research related to life sciences.</p>

Biotin-PEG2-C6-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

Isooxoflaccidin is a natural product for research related to life sciences. The catalog number is TN5785 and the CAS number is 135010-50-3.

<p>Succinate dehydrogenase-IN-4 (Compound 4b) is an inhibitor of succinate dehydrogenase with an IC50 value of 3.38 μM. It exhibits antifungal activity against Physalospora piricola and Colletotrichum orbiculare, with EC50 values of 16.33 μM and 18.06 μM, respectively.</p>

Rutamarin is a natural product for research related to life sciences. The catalog number is TN5884 and the CAS number is 13164-05-1.

<p>BDP 650/665 azide is an azide group labeled with BDP 650/665, a BODIPY dye that has a maximum excitation wavelength of 650 nm and a maximum emission wavelength of 665 nm. It is suitable for use in click chemistry.</p>

8-(1,1-Dimethyl-2-propenyl)kaempferol is a natural product for research related to life sciences.

<p>2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate is a natural product that can be used as reference standards.</p>

<p>Tatsinine is a natural product for research related to life sciences. The catalog number is TN6084 and the CAS number is 90038-21-4.</p>

<p>Phenethyl butyrate is an organic ester compound commonly used in the fragrance industry, employed in drug synthesis research.</p>