Other Inhibitors

PD-1/PD-L1-IN-13 is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM for PD-1/PD- L1 interaction.PD-1/PD-L1-IN-13 promotes CD8+ T-

Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.

ENPP1-IN-12 is a potent, oral ENPP1 inhibitor with a Ki of 41 nM and anti-tumor properties.

Amdinocillin methylacetate is a Synthetic penicillin.

Difeterol is a biochemical.

Henagliflozin (SHR3824): an oral, selective SGLT2 inhibitor, weak on SGLT1.

Coriolin A exhibits activity against gram-positive bacteria, weakly against gram-negative bacteria, as well as yeasts and Trichomonas vaginalis. At a concentration of 5 μg/mL, it inhibits 61.6% of the growth of Yoshida sarcoma, but shows no inhibitory effect on Ehrlich ascites carcinoma in animals.

KNI 10033 is a potent inhibitor of HIV protease

PDE4-IN-6: Potent PDE4 inhibitor, IC50 - 0.125μM (B), 0.43μM (D), anti-inflammatory, for arthritis research.

Luffariellolide is a terpene compound obtained from the marine sponge Hyrtios communis that is an HSF-PLA2 inhibitor and a RAR agonist.

DC1, a CC-1065-like ADC cytotoxin, is used in cancer-targeting antibody-drug conjugates. DC1Sme, a derivative, has IC50s: 22-250 pm in various cancer cells.

β-Carotene-15,15ʹ-epoxide acts as an XIAP antagonist with pro-apoptotic (Apoptosis) and anti-tumor properties, found in the leaves of Spondias mombin. In rat models of DMBA-induced breast cancer, it induces tumor cell apoptosis by binding to the BIR3 domain of the XIAP protein, thereby inhibiting its interaction with caspase-9. Additionally, β-carotene-15,15ʹ-epoxide significantly reduces BCL-2, COX-2, and TNF-α expression in tumor tissue, decreases MDA levels, enhances catalase activity, and modulates biochemical markers in serum such as LDH, ALP, and ALT, indicating its antioxidant, anti-inflammatory, and metabolic protective effects. This compound is useful for researching inflammation-related diseases and tumors such as breast cancer.

Salfredin C3 is an inhibitor of aldose reductase (aldose reductase).

Avorelin acetate is a luteinizing hormone releasing hormone (LH-RH) agonist.

Kynapcin-28 is a non-competitive inhibitor of prolyl endopeptidase (PEP) with an IC50 of 76.80 μM and exhibits weak inhibitory effects on other serine proteases.

4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.

NAPAP is a thrombin inhibitor with potent anticoagulant activity (Ki: 2.1 nM). It selectively inhibits thrombin through a rapid binding mechanism while exhibiting weaker inhibition of trypsin, Factor Xa, and plasmin. NAPAP can be utilized for research into thrombotic conditions, including venous thrombosis and myocardial infarction.

Deoxyradicinin is a biosynthetic precursor of Radicinin. It can inhibit Xylella fastidiosa and Liberibacter crescens, with a minimum inhibitory concentration (MIC) of 3.5 μg/mL against Liberibacter crescens. Deoxyradicinin is applicable for research on controlling plant diseases caused by these pathogens.