Other Inhibitors

Mal-PEG3-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

<p>Chysin A is a natural product that can be used as a reference standard.</p>

<p>Strictamine is a akuammiline alkaloid.</p>

<p>EZH2-IN-6 is an EZH2 inhibitor with enhanced antitumor activity.</p>

<p>ELX-02 sulfate (NB-124), an ERSG in development, targets genetic diseases caused by nonsense mutations.</p>

<p>Xylyl isothiocyanate is a biochemical.</p>

<p>Leptoside is a bioactive chemical.</p>

<p>1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a type of polychlorinated dibenzofuran (PCDF). It promotes the expression of aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) genes in H-4-II-E rat hepatoma cells with EC50 values of 1.47 and 1.24 nM, respectively. 1,2,3,6,7,8-HxCDF also reduces rat body weight, causes thymic atrophy, and induces the expression of cytochrome P450 (CYP) subtype CYP1A1 and 4-chlorobiphenyl hydroxylase genes with EC50 values of 3.2, 0.9, 0.35, and 0.21 µmol/kg.</p>

<p>Mimbane is a biochemical.</p>

<p>25-Acetylcimigenol xyloside is a useful organic compound for research related to life sciences. The catalog number is T125131 and the CAS number is 27994-12-3.</p>

<p>Austocystin C is a useful organic compound for research related to life sciences. The catalog number is T124666 and the CAS number is 55256-55-8.</p>

<p>Ceplignan is a useful organic compound for research related to life sciences and the catalog number is T125512.</p>

<p>5-Hydroxy-6-methoxy (S)-Duloxetine, a metabolite of (S)-duloxetine, binds to neurotransmitter transporters with varying affinities.</p>

<p>cADP-ribose, a NAD+ metabolite, triggers Ca2+ release from endoplasmic reticulum and influences TRPM2 channel activity.</p>

<p>Samwirin A is a promising radical scavenger in aqueous media at physiological pH.</p>

<p>R-3828 is a biochemical.</p>

<p>4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid lowers blood sugar, acting upon oral glucose response.</p>

<p>Methyl lucidenate C is a natural product that can be used as a reference standard.</p>

<p>Fumaritine is a natural product that can be used as a reference standard. The CAS number of Fumaritine is 24181-78-0.</p>

<p>KW 2149 is a compound derived from mitomycin C.</p>

<p>CAY10599 has a wide range of applications in life science related research.</p>

<p>Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(2-(dimethylamino)ethyl)-, hydrochloride is a bioactive chemical.</p>

<p>3-Epidehydropachymic acid is a natural product</p>

<p>Ugodotin is an antibody-drug conjugate. Ugodotin can binds IGF-1R with antitumor activity.</p>

<p>N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a PEG-based linker used in PROTAC synthesis.</p>

<p>Ruberythric acid is a useful organic compound for research related to life sciences and the catalog number is T125756.</p>

<p>Wedelin is a biochemical.</p>

<p>Brosimacutin G is a useful organic compound for research related to life sciences and the catalog number is T124983.</p>

<p>3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone is a useful organic compound for research related to life sciences and the catalog number is T126386.</p>

<p>Tos-PEG8-m, a PEGylated PROTAC linker from silybin ethers, used in Silymarin synthesis, linked to CN105037337A patent.</p>

<p>Dextrorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.</p>

<p>Dactylyne is a new drug metabolism inhibitor of marine origin. It was isolated from the sea hare Aplysia dactylomela and characterized pharmacologically.</p>

<p>Human vitamin D-binding protein (hDBP) is an abundant, multifunctional, and highly polymorphic serum glycoprotein synthesized by the liver1.</p>

<p>UDP-N-acetyl-D-glucosamine: nucleotide sugar for glycosylation, key in fungi antibiotic synthesis, and bacterial lipopolysaccharide production.</p>

<p>Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .</p>

<p>m-PEG4-phosphonic acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>Deacetylsolaphyllidine is a biochemical.</p>

<p>CBB1003 hydrochloride is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM).</p>

Compound TJS1874 is a useful organic compound for research related to life sciences. The catalog number is TJS1874 and the CAS number is 26000-17-9.

<p>S62798 is a highly potent and selective compound that inhibits activated thrombin activatable fibrinolysis inhibitor (TAFIa) with an IC50 value of 6 mM.</p>

5-O-Ethylcleroindicin D is a natural product for research related to life sciences. The catalog number is TN5829 and the CAS number is 488138-32-5.

<p>Tri-GalNAc-PEG3-Azide is a specialized compound designed for lysosomal targeting chimera (LYTAC) research, featuring three asialoglycoprotein receptor (ASGPR)</p>

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).

<p>4',5,7-Trihydroxy 3,6,8-trimethoxyflavone is a useful organic compound for research related to life sciences and the catalog number is T124632.</p>

<p>1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA (1-palmitoyl-d9LPA) serves as an internal standard for the quantification of 1-palmitoyl LPA using GC- or LC-MS. This compound, an analog of LPA with palmitic acid at the sn-1 position, activates reporter gene expression in PC12 cells fitted with human lysophosphatidic acid receptor 4 (LPA4) at 0.01 to 10 µM concentrations. Additionally, 1-palmitoyl LPA prompts aggregation in isolated human platelets within the 12-300 µM range, a process reversible by prostaglandin E1 (PGE1), theophylline, or EDTA. It also interacts with calcium and magnesium to boost the efficacy of ampicillin, piperacillin, and ceftazidime against P. aeruginosa strains from cystic fibrosis patients.</p>

<p>TGFβR-IN-1 is a long-acting tumor-activated proagent of a TGFβR inhibitor.</p>

<p>NP213 TFA: first synthetic AMP with fast-acting anti-fungal action, disrupts fungal membranes.</p>

<p>m-PEG10-SH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>DBCO-PEG2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>Scorpioidine is a useful organic compound for research related to life sciences and the catalog number is T124194.</p>

<p>Nicotinamide, N-(2-pyridyl)- is a biochemical.</p>

<p>Lynestrenol mixture with mestranol is a bioactive chemical.</p>

<p>AMG-580 F-18 is a biochemical.</p>

<p>L-367,773 is a bioactive chemical.</p>

<p>Cubebin is a useful organic compound for research related to life sciences and the catalog number is T126158.</p>

<p>VinSpinIC is an inactive control for VinSpinIn.</p>

Lutonarin (Isoorientin 7-O-glucoside) is a natural product found in aerial part of Silene jeniseensis.

<p>Decamethylene dibenzoate is a biochemical.</p>

<p>Avermectin B1a aglycone is an anthelmintic/insecticide that hyperpolarizes muscle fibers and kills C. elegans at 0.1 μM.</p>

<p>O-Demethyldeacetyldiltiazem hydrochloride is a biochemical.</p>

<p>Iloperidone metabolite P95, a non-brain penetrating compound, binds 5-HT2A, α1-, α2B-, α2C-receptors with Ki of 7.08-83.18 nM.</p>

<p>α-CGRP (rat) acetate is a calcitonin gene-related peptide (CGRP). CGRP (rat) acetate is a potent vasodilator.</p>

Y 36912 is a biochemical.

<p>Diketone-PEG4-PFP ester is a polyethylene glycol (PEG) derivative employed as a PROTAC linker in the fabrication of proteolysis-targeting chimeras (PROTACs)[1].</p>

<p>Stachartin E is a natural product from the cultures of the tin mine tailings-associated fungus Stachybotrys chartarum.</p>

<p>Toxyloxanthone D is a useful organic compound for research related to life sciences and the catalog number is T124746.</p>

<p>Methyltetrazine-PEG24-NH-Boc is a PEG-derived linker for PROTAC synthesis[1].</p>

<p>Benzenesulfonic acid, 3-(2-(4-(2-(4-((2-cyanoethyl)ethylamino)-2-methylphenyl)diazenyl)-1-naphthalenyl)diazenyl)- is a bioactive chemical.</p>

<p>ONO-8711 is a potent and selective competitive antagonist of EP1 receptor with Kis of 0.6 nM and 1.7 nM for human and mouse EP1, respectively.</p>

Mal-PEG5-NHS ester, an alkyl/ether and PEG-based PROTAC linker, is utilized for the synthesis of PROTACs.

<p>4-Nitrophenyl β-D-Cellotetraoside can be used in related research in the field of life sciences. Its product number is T37573 and CAS number is 129411-62-7.</p>

3,6-Diisobutylpyrazin-2(1H)-one is an organic compound containing a pyrazine ring that is used in organic synthesis and biochemical experiments.

<p>N-Methylcorydaldine is a useful organic compound for research related to life sciences. The catalog number is T124472 and the CAS number is 6514-05-2.</p>

<p>Diorcinol is a natural product that can be used as a reference standard. The CAS number of Diorcinol is 20282-75-1.</p>

<p>N-Nitroso sarcosine is a carcinogen and nitrosation product of sarcosine that has been found in cured meat products.1,2</p>

<p>S-Acetyl-L-glutathione boosts intracellular GSH, induces lymphoma cell apoptosis, and inhibits HSV-1 replication, improving survival in HSV-1 mice.</p>

<p>Benzyl-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>Msh (11-13) is a bioactive chemical.</p>

<p>Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent</p>

<p>FITC-labeled Agatolimod (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and</p>

<p>Darapladib-impurity is the impurity of Darapladib. Darapladib inhibits lipoprotein-associated phospholipase A2 (Lp-PLA2).</p>

<p>Valconazole is a bioactive chemical.</p>

<p>(S)-6-methoxychroman-3-carboxylic acid is a synthetic C11H10O5 compound, part of the seven-membered ring chroman family.</p>

<p>Apobioside is a natural product that can be used as a reference standard. The CAS number of Apobioside is 1941-73-7.</p>

<p>Azido-PEG11-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>LS 105790 is a bioactive chemical.</p>

<p>MPEG-2000-DSPE is a liposome-synthesizing phospholipid PEG that enhances hydrophilicity and blood circulation longevity for cancer and malaria research.</p>

<p>3-hydroxy lignoceric acid: a 24-C hydroxylated lignoceric acid, minor in Methyloligella, intermediate in acyl-CoA fatty acid elongation.</p>

<p>6-Acetyldepheline, a natural alkaloid, can be isolated from Delphinium tatsienense.</p>

<p>DGN549-L is a DNA alkylator that facilitates antibody conjugation at lysine residues, making it suitable for antibody-drug conjugate (ADC) synthesis.</p>

<p>Hexanoic acid, 3-methylphenyl ester is a bioactive chemical.</p>

<p>Myristoyl-CoA, derived from CoA with myristic acid, is used in protein myristoylation and phosphatidylinositol synthesis.</p>

<p>Dibromsalicil is a biochemical.</p>

Expression System: HEK293 Cells<br>Activity: /

<p>Questinol fights obesity, reduces inflammation and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), and inhibits NO and PGE2 in cells.</p>

<p>9,10-Dichlorostearic acid, a chlorinated antimutagen, damages tumor cell membranes, causing ATP leakage.</p>

<p>Cyclooctyne-O-amido-PEG3-PFP ester is a non-cleavable 3-unit PEG linker employed in the synthesis of antibody-drug conjugates (ADCs).</p>

<p>EC17 is Folate-FITC, fluoresces at 500nm, targets FRα, and may have anticancer properties.</p>

<p>(R,R)-DuP 747-HCl is a Dup 747 derivative.</p>

<p>Compound N069-0074 is a useful organic compound for research related to life sciences and the catalog number is T131184.</p>

<p>KP-81 is a structurally complex aromatic compound used in organic synthesis and drug design.</p>

<p>Zeylasteral is a natural product that can be used as a reference standard.</p>

<p>O-Desethyl sildenafil is a metabolite of the phosphodiesterase 5 (PDE5) inhibitor sildenafil .1</p>

<p>Cimicifuga racemosa extract, derived from the black cohosh plant, is an herbal compound with anti-estrogenic properties. It is commonly used to alleviate menopausal symptoms, including hot flashes and night sweats.</p>

<p>Acetamide, N-(5-(p-aminophenoxy)pentyl)-2-phenyl- is a bioactive chemical.</p>

<p>L-870812 is a bioactive chemical.</p>

<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>