Other Inhibitors

<p>2-Aminobenzamide: a stable, neutral fluorescent tag used in glycan analysis and as a precursor for key reactions.</p>

<p>Diphenyl cresyl phosphate is a flame retardant, plasticizers, additives of gasoline, and lubricant.</p>

Diflumidone, a non-steroidal, is an antiinflammatory drug.

<p>Sulphenone is an agent of Acaricide.</p>

<p>Dequalinium: quaternary ammonium, bolaamphiphile, mainly as dichloride; also as bromide, iodide, acetate, undecenoate salts.</p>

<p>Distearyl thiodipropionate is an agent of biochemical.</p>

<p>Benzo[f]tetraphene, also known as Dibenz[a,c]anthracene, is a polycyclic aromatic hydrocarbon utilized as a luminescent probe in cellular biology for effective detection of reactive oxygen species. Additionally, it has potential applications as a photosensitizer, demonstrating promising prospects in photodynamic inhibition.</p>

<p>Carbamic acid, (3-hydroxyphenyl)-, phenylmethyl ester (9CI) is a bioactive chemical.</p>

<p>Ammonium, (3-(p-trimethylammoniophenyl)propyl)trimethyl-, diiodide is a bioactive chemical.</p>

<p>Monooctyl succinate can be used as a surfactants and a potential fragrance releaser.</p>

<p>In Organic Synthesis, Phenyltrimethylammonium tribromide is a Versatile Reagent.</p>

<p>m-PEG16-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>4-(Benzyloxy)-2-nitrophenol serves as a synthetic precursor for constructing fluorescent ion indicators [1].</p>

<p>Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family.</p>

<p>4-(Dimethylamino)-3'-fluoroazobenzene is a bioactive chemical.</p>

<p>Ascorbyl myristate is a bioactive chemical.</p>

<p>Pantoyltaurine is a biochemical.</p>

<p>Tetradecanenitrile is an agent of biochemical.</p>

<p>Human IgG2 kappa, Isotype Control is a chimeric antibody from HEK293 cells, used as a control for non-specific binding in experiments.</p>

<p>Bucladesine mimics cAMP, permeates cells, and inhibits phosphodiesterase; used in research.</p>

<p>Allantoin glycyrrhetinic acid is a protein aggregate suppressor.</p>

<p>AG 2000 is a biochemical.</p>

<p>Padimate A is a sunscreen ingredient.</p>

<p>Monoethanolamine caprate is a biochemical.</p>

<p>NSC57971 is a novel non-peptide interference of the IKKß/NEMO complex.</p>

<p>Palmitoyl alanine is a fatty acid.</p>

<p>AA560 is a nonsteroidal antiandrogen. AA560 decreases the uptake of 3H-androgens in the ventral prostate and decreases the weight of accessory organs.</p>

<p>DC4 crosslinker, an 18Å mass spectrometry-cleavable crosslinking reagent, features two intrinsic positive charges facilitating the fragmentation of cross-linked peptides into their constituent peptides through collision-induced dissociation or in-source decay. Initial fragmentation leads to cleavage adjacent to the positive charges, enabling the identification of cross-linked peptides as pairs of ions with precise mass separation. Furthermore, the resultant intact peptide fragments can undergo further fragmentation, producing a sequence of b- and y-ions for peptide identification.</p>

<p>8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA) and a potent inhibitor of cyclic GMP-specific phosphodiesterase (PDE VA) with an inhibitory concentration (IC50) of 0.9 μM. It also inhibits PDE III and PDE IV while significantly activating Epac, demonstrating diverse pharmacological activities [1] [2].</p>

<p>Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by</p>

<p>C20 Ceramide (N-Arachidoyl-D-sphingosine) is a 20:0 ceramide found in the brain that crosses the blood-brain barrier to activate microglia and induce depressive</p>

<p>D-Ribulose-5-phosphate sodium salt (Ru5P sodium salt) can be used to synthesize lipopolysaccharides and amino acids.</p>

<p>Avenacein Y is a biochemical.</p>

<p>Didocosanoin, a diacylglycerol, incorporates the saturated 22-carbon fatty acid, docosanoic acid, at both of its positions.</p>

<p>Alamethicin is isolated from Trichoderma viride. It is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes.</p>

<p>α-Cortolone, a metabolite of the glucocorticoid cortisol (hydrocortisone), is produced through the action of 20α-hydroxysteroid dehydrogenase (20α-HSD) via a tetrahydrocortisone (THE) intermediate. Studies indicate that urinary levels of α-cortolone are reduced in patients experiencing severe anorexia nervosa and postmenopausal women diagnosed with endometrial adenocarcinoma, in comparison to postmenopausal women without the condition.</p>

<p>Filipin III is extracted from strain KPE18H and has significant antifungal activity.</p>

<p>PBFI-AM is a useful tool to determine intracellular K + content [1] .</p>

<p>QLT0267 is an inhibitor targeting integrin-linked kinase (ILK; IC50= 26 nM), showing over 10-fold selectivity against cyclin-dependent kinases 1, 2, and 5 (Cdk1, Cdk2, and Cdk5), and over 1,000-fold selectivity against C-terminal Src kinase (CSK), DNA-PK, Pim-1, Akt, PKC, and casein kinase 2 (CK2) at a concentration of 10 mg/ml. This compound effectively inhibits the proliferation of NPA187 papillary thyroid cancer cells with an IC50 of approximately 3 µM and induces apoptosis in NPA187, DRO, and K4 cancer cell lines. In vivo studies reveal that QLT0267, administered at 100 mg/kg, significantly reduces tumor growth in a DRO mouse xenograft model and diminishes both tumor volume and intratumoral vascularization in a U87MG glioblastoma mouse xenograft model, showcasing its potential for therapeutic applications in cancer treatment.</p>

<p>C24 Phytosphingosine is a long-chain phytoceramide found in skin, intestines, and kidneys, used in research on skin permeability and psoriasis.</p>

<p>BAY-390, a selective TRPA1 inhibitor, crosses species, penetrates brains, with IC50s: 16-82 nM. Used in inflammation research.</p>

<p>N-Acylethanolamines (NAEs) are lipid-derived signaling compounds, with arachidonoyl ethanolamide functioning as an endogenous cannabinoid (CB) that activates CB1 and CB2 receptors. Among these, Palmitoleoyl Ethanolamide (POEA) is synthesized endogenously from palmitoleic acid. Notably, unlike arachidonoyl ethanolamide and palmitoyl ethanolamide, POEA lacks antinociceptive effects in the formalin-evoked pain model.</p>

<p>4-Aminophenylphosphorylcholine, when conjugated to sepharose, serves as an effective adsorbent for affinity precipitation experiments. This compound functions as a probe facilitating selective binding and isolation processes in biochemical studies.</p>

<p>PNU 142300 is an inactive metabolite of the oxazolidinone antibiotic linezolid .</p>

<p>Nicotianamine, an amino acid that chelates iron, facilitates the absorption of iron from the soil.</p>

C22 glucosylceramide, a skin lipid membrane component, aids water barrier function and serves as a biochemical precursor.

<p>C18 Sphingomyelin (d18:1/18:0) is a lipid molecule that can be used in life science related research. The CAS number of C18 Sphingomyelin (d18:1/18:0) is 54336-69-5.</p>

<p>Aldehyde Reactive Probe TFA (ARP TFA) is an aldehyde-reactive probe used to detect the level of abasic sites in plant mRNA.</p>

<p>Leukotriene E4 (LTE4) (LTE4) is generated by the action of dipeptidyl peptidase on LTD4, is present in plasma and urine, and can be used to detect asthma.</p>

<p>Gibberellin A14 is a useful organic compound for research related to life sciences. The catalog number is T124777 and the CAS number is 4955-22-0.</p>