Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1530 products of "Cytoskeletal Signaling"
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AKT-IN-11
AKT-IN-11 is one of the most potent antibacterial agents against human hepatocellular carcinoma Bel-7402 cell line (IC50: 1.15 μM).Formula:C27H27ClF3NO4Color and Shape:SolidMolecular weight:521.96FO-4-15
CAS:FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.Formula:C18H20N4O4SColor and Shape:SolidMolecular weight:388.44PROTAC α-synuclein degrader 6
CAS:<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>Formula:C37H39N5O9SMolecular weight:729.80Monomethyl auristatin E intermediate-17
CAS:MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).Formula:C27H35NO7SMolecular weight:517.63Terpendole E
CAS:Terpendole E is an atypical L5 site inhibitor.Formula:C28H39NO3Color and Shape:SolidMolecular weight:437.61Nrf2/HO-1 activator 2
Compound 13m, a difluoro derivative, activates Nrf2/HO-1, showing neuroprotective and antioxidant effects, useful in PD research.Formula:C20H16F2O5Color and Shape:SolidMolecular weight:374.33Uprosertib hydrochloride
CAS:Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).Formula:C18H17Cl3F2N4O2Purity:98%Color and Shape:SolidMolecular weight:465.71KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85Hsp90-IN-38
CAS:<p>Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.</p>Formula:C28H35N3O5Color and Shape:SolidMolecular weight:493.595AKT-IN-26
CAS:AKT-IN-26 (Compound 453) is an AKT inhibitor that binds to the Pleckstrin Homology (PH) domain of AKT. It is useful for research related to cell proliferation and cancer involving the AKT pathway.Formula:C21H17N5O4SColor and Shape:SolidMolecular weight:435.456Antitumor agent-200
CAS:Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.Formula:C19H21FN2O3SeColor and Shape:SolidMolecular weight:423.34Tubulin inhibitor 15
Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].Formula:C16H12FNO2Color and Shape:SolidMolecular weight:269.27HSP90α-IN-1
CAS:HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.356SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formula:C23H27F2N5O4Color and Shape:SolidMolecular weight:475.49INS018 055
CAS:INS018 055 (TNIK&MAP4K4-IN-2) is a TNIK and MAP4K4 inhibitor with anti-fibrotic activity.Formula:C27H30FN7OPurity:98.53%Color and Shape:SolidMolecular weight:487.57NRX-1532
NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.Formula:C16H11F3N4O2Purity:98.95% - 99.94%Color and Shape:SolidMolecular weight:348.28Ref: TM-T61172
1mg156.00€5mg378.00€10mg630.00€25mg1,216.00€50mg1,634.00€100mg2,205.00€500mg4,418.00€1mL*10mM (DMSO)415.00€AKT Kinase Inhibitor
CAS:AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.Formula:C16H19N7O3Purity:97.83% - 99.13%Color and Shape:SolidMolecular weight:357.37Ref: TM-T10276
1mg136.00€5mg329.00€10mg567.00€25mg887.00€50mg1,188.00€100mg1,605.00€1mL*10mM (DMSO)360.00€NRX-252114
CAS:NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Formula:C22H12Cl2F3N3O2SPurity:99.70%Color and Shape:SolidMolecular weight:510.32NRX-103094
CAS:NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formula:C20H11Cl2F3N2O4SPurity:99.13%Color and Shape:SolidMolecular weight:503.28Ombrabulin
CAS:Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.Formula:C21H26N2O6Purity:98%Color and Shape:SolidMolecular weight:402.4420-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Formula:C20H32O3Purity:99.79%Color and Shape:SolidMolecular weight:320.4724-Methylenecycloartanyl ferulate
CAS:24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.Formula:C41H60O4Color and Shape:SolidMolecular weight:616.927Cercosporin
CAS:Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).Formula:C29H26O10Purity:98%Color and Shape:SolidMolecular weight:534.51Tau tracer 2
CAS:Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].Formula:C15H9FN4Color and Shape:SolidMolecular weight:264.263Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate
CAS:Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T65302 and the CAS number is 20367-38-8.Formula:C9H8ClN3O2Color and Shape:SolidMolecular weight:225.63ZW4864
CAS:ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.Formula:C33H43ClN6O3Color and Shape:SolidMolecular weight:607.2Sevasemten
CAS:Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.Formula:C16H11F4N5O2Color and Shape:SolidMolecular weight:381.28CMX-2043
CAS:CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.Formula:C16H26N2O6S2Purity:98%Color and Shape:SolidMolecular weight:406.52Cevipabulin fumarate
CAS:Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).Formula:C22H22ClF5N6O5Purity:98%Color and Shape:SolidMolecular weight:580.89BCR-ABL-IN-8
CAS:<p>BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].</p>Formula:C30H33N7O5Purity:98%Color and Shape:SolidMolecular weight:571.63
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