Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1472 products of "Cytoskeletal Signaling"
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KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85ZLY06
CAS:<p>ZLY06 is a dual agonist of peroxisome proliferator-activated receptors (PPAR) δ and γ with oral activity (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). It mediates the upregulation of CD36 and induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1. Moreover, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, primarily by enhancing the β-oxidation of fatty acids and reducing hepatic lipid synthesis, thereby alleviating fatty liver disease.</p>Formula:C25H26O6Color and Shape:SolidMolecular weight:422.47DCEM1
CAS:<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Formula:C22H23N3O2SColor and Shape:SolidMolecular weight:393.50Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Formula:C31H35N3O6Color and Shape:SolidMolecular weight:545.63AM-9022
CAS:AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].Formula:C27H36F2N6O4SColor and Shape:SolidMolecular weight:578.67Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formula:C32H59ClN6O5Purity:98%Color and Shape:SolidMolecular weight:643.30INS018 055
CAS:INS018 055 (TNIK&MAP4K4-IN-2) is a TNIK and MAP4K4 inhibitor with anti-fibrotic activity.Formula:C27H30FN7OPurity:98.53%Color and Shape:SolidMolecular weight:487.57NRX-252114
CAS:NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Formula:C22H12Cl2F3N3O2SPurity:99.70%Color and Shape:SolidMolecular weight:510.32NRX-1532
NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.Formula:C16H11F3N4O2Purity:98.95% - 99.94%Color and Shape:SolidMolecular weight:348.28NRX-103094
CAS:NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formula:C20H11Cl2F3N2O4SPurity:99.13%Color and Shape:SolidMolecular weight:503.28AKT Kinase Inhibitor
CAS:AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.Formula:C16H19N7O3Purity:97.83% - 99.13%Color and Shape:SolidMolecular weight:357.37Ombrabulin
CAS:Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.Formula:C21H26N2O6Purity:98%Color and Shape:SolidMolecular weight:402.44Tau tracer 2
CAS:Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].Formula:C15H9FN4Color and Shape:SolidMolecular weight:264.263Cercosporin
CAS:<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Formula:C29H26O10Purity:98%Color and Shape:SolidMolecular weight:534.51Sevasemten
CAS:<p>Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.</p>Formula:C16H11F4N5O2Color and Shape:SolidMolecular weight:381.2820-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Formula:C20H32O3Purity:99.79%Color and Shape:SolidMolecular weight:320.4724-Methylenecycloartanyl ferulate
CAS:24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.Formula:C41H60O4Color and Shape:SolidMolecular weight:616.927Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate
CAS:Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T65302 and the CAS number is 20367-38-8.Formula:C9H8ClN3O2Color and Shape:SolidMolecular weight:225.63ZW4864
CAS:ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.Formula:C33H43ClN6O3Color and Shape:SolidMolecular weight:607.2CMX-2043
CAS:<p>CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.</p>Formula:C16H26N2O6S2Purity:98%Color and Shape:SolidMolecular weight:406.52Cevipabulin fumarate
CAS:Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).Formula:C22H22ClF5N6O5Purity:98%Color and Shape:SolidMolecular weight:580.89BCR-ABL-IN-8
CAS:<p>BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].</p>Formula:C30H33N7O5Purity:98%Color and Shape:SolidMolecular weight:571.63
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