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Cytoskeletal Signaling

Cytoskeletal Signaling

Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.

Found 1472 products of "Cytoskeletal Signaling"

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  • HSN748
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    HSN748

    CAS:
    <p>HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.</p>
    Formula:C27H24F3N7O
    Color and Shape:Solid
    Molecular weight:519.521

    Ref: TM-T204396

  • Terpendole E
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    Terpendole E

    CAS:
    Terpendole E is an atypical L5 site inhibitor.
    Formula:C28H39NO3
    Color and Shape:Solid
    Molecular weight:437.61

    Ref: TM-T70289

  • MKLP2-IN-1
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    MKLP2-IN-1

    CAS:
    <p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>
    Formula:C23H19BrFN3O2
    Color and Shape:Solid
    Molecular weight:468.318

    Ref: TM-T205538

  • Tyrosine kinase-IN-9
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    Tyrosine kinase-IN-9

    CAS:
    <p>Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>
    Formula:C20H14ClN3O3
    Color and Shape:Solid
    Molecular weight:379.796

    Ref: TM-T205576

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    Tubulin inhibitor 19

    Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.
    Formula:C21H23NO5
    Color and Shape:Solid
    Molecular weight:369.41

    Ref: TM-T61459

  • Cemdomespib
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    Cemdomespib

    CAS:
    Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.
    Formula:C24H30FNO6
    Color and Shape:Solid
    Molecular weight:447.5

    Ref: TM-T62670

  • Lisavanbulin
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    Lisavanbulin

    CAS:
    <p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>
    Formula:C26H29N9O3
    Color and Shape:Solid
    Molecular weight:515.57

    Ref: TM-T88188

  • TACC3 inhibitor 2
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    TACC3 inhibitor 2

    CAS:
    <p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>
    Formula:C20H22FN5O2
    Color and Shape:Solid
    Molecular weight:383.419

    Ref: TM-T205299

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    α5β1 integrin agonist-1

    CAS:
    α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.
    Formula:C24H26FN5O9
    Color and Shape:Solid
    Molecular weight:547.49

    Ref: TM-T63868

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    Zalunfiban dihydrochloride

    <p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>
    Formula:C16H20Cl2N8O2S
    Color and Shape:Solid
    Molecular weight:459.35

    Ref: TM-T62878

  • GR 83895
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    GR 83895

    CAS:
    GR 83895 is an antagonist of prototype fibrinogen receptor.
    Formula:C29H39N9O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:673.74

    Ref: TM-T25460

  • EX05
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    EX05

    CAS:
    EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.
    Formula:C26H30F2N4O5S
    Color and Shape:Solid
    Molecular weight:548.60

    Ref: TM-T88621

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    Tubulin polymerization-IN-33

    <p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>
    Formula:C27H28N2O6
    Color and Shape:Solid
    Molecular weight:476.52

    Ref: TM-T63111

  • NVP-BQS481
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    NVP-BQS481

    CAS:
    NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).
    Formula:C27H33F3N4O2
    Color and Shape:Solid
    Molecular weight:502.57

    Ref: TM-T212559

  • L 734217
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    L 734217

    CAS:
    L 734217 is an antagonist of the fibrinogen receptor.
    Formula:C18H31N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:353.46

    Ref: TM-T24352

  • PM-060184
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    PM-060184

    CAS:
    <p>PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.</p>
    Formula:C31H45N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:571.7

    Ref: TM-T28428

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    MT-134

    MT-134 is a SkMII -specific inhibitor and has excellent exposure in muscles.
    Formula:C19H16N4O3
    Color and Shape:Solid
    Molecular weight:348.36

    Ref: TM-T61174

  • Alfalone
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    Alfalone

    CAS:
    <p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>
    Formula:C17H14O5
    Color and Shape:Solid
    Molecular weight:298.29

    Ref: TM-T204260

  • TTBK1/2-IN-1
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    TTBK1/2-IN-1

    CAS:
    <p>TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.</p>
    Formula:C17H16N4O
    Color and Shape:Solid
    Molecular weight:292.335

    Ref: TM-T206307

  • KY-02327 acetate
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    KY-02327 acetate

    KY-02327 acetate inhibits Dvl-CXXC5, stabilizes Wnt/β-catenin signaling, and enhances osteoblast differentiation.
    Formula:C22H31N3O6
    Color and Shape:Solid
    Molecular weight:433.5

    Ref: TM-T62436