Deuterated Compounds

<p>Applications N,O-Bis(trimethyl-d9-silyl)acetamide &gt;90% (cas# 203784-65-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (±)-Prasugrel-d3 (acetate-d3) (CAS# 1127253-02-4) is a useful isotopically labeled research compound. This compound can be used for treating percutaneous coronary intervention.<br>References Czarnik, A., U.S. Pat. Appl. Publ., 9,(2009);<br></p>

<p>Applications 1,2,3,5-Tetramethylbenzene-d14 (CAS# 1219795-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Fluorotoluene-alpha,alpha,alpha-d3 (CAS# 4202-92-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromooctadecane-18,18,18-d3 (CAS# 349553-85-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Bis(trifluoromethyl)benzene-13C6 is an intermediate in the synthesis of Dutasteride-13C6 (D735002), which is a labeled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>

<p>Applications 3,5-Dichloroaniline-2,4,6-d3 (CAS# 1219795-03-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications m-Toluidine-d7 (NH2) (CAS# 68408-25-3) is a useful isotopically labeled research compound. Due to the H-D reaction, this compound can be used as a mixed catalystic for its synergistic effect.<br>References Ito, N., et.al., Synthesis, 9, 1467-1478,(2008);<br></p>

<p>Applications 1,3,5-Tris(3-chloro-2-hydroxypropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione-d15 is an intermediate for the synthesis of Triglycidyl Isocyanurate-d15 (T793817). Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain.<br>References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)<br></p>

<p>Applications n-Decyl-d21-trimethylammonium Bromide (CAS# 1515861-67-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(3,4-Dihydroxyphenyl)ethyl-1,1-d2-amine HCl (CAS# 83008-33-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled 1,3,5-Xylenol, is a versatile building block used in the synthesis of a more complex compounds. It is the precursor in the preparation of 3,5-Xylenol Phosphate (3:1) (X749550).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Makarenko, I. M., et al.: Deposited Doc.,7 (1975);<br></p>

<p>Applications 1-Adamantan-d15-amine is a labeled NMDA-receptor antagonist. Antiviral; antiparkinsonian.<br>References Vernier, V.G., et al; Toxicol. Appl. Pharmacol., 15, 642 (1969); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 12, 1 (1983)<br></p>

<p>Applications 2-Fluoroaniline-4,6-d2,ND2 (CAS# 1219804-77-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Decane-d22 was useful for neutron imaging of liquid swelling and surface phenomena during methane absorption in ethanol and n-​decane under high pressure.<br>References Vopicka, O., et al.: PLoS One, 15, 0238470 (2020)<br></p>

<p>Applications Phenylacetylene-d6 (CAS# 25837-47-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chloro-2-(methyl-d3)phenol is an intermediate used in the synthesis of (4-Chloro-2-methylphenoxy)acetic Acid-d3 (C369473), which is a deuterated version of (4-Chloro-2-methylphenoxy)acetic Acid (C369470), a herbicide.<br>References Elliott, B., et al.: Mutagenesis, 20, 3 (2005); Pfleeger, T., et al.: Environ. Toxicol. Chem., 30, 455 (2010);<br></p>

<p>Applications N-Acetyl-L-alanine-3,3,3-d3 is deuterium labelled form of N-Acetyl-L-alanine (A168065), which is used as a biomarker for prostate cancer.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005);<br></p>

<p>Applications Cyclopentanone-d8 (CAS# 4477-17-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Ethyl-m-xylene-d5, is the labeled analogue of 2-Ethyl-m-xylene (E932360), one of the components thermocontact pyrolysis tars. It has been also found to be one of the volatile organic emissions from Motor Vehicles, that might have impact on ozone production.<br>References Koretskaya, N. A., Neftepererabotka i Neftekhimiya, 10, 44 (1978); Gentner, D. R., et al.: Environ. Sci. Tech., 47, 11837 (2013);<br></p>

<p>Applications Dimethyl Hexanedioate-3,3,4,4-d4 (CAS# 55724-08-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetraethoxy-d20-silane (CAS# 272778-10-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Propineb-d3 is the labeled analog of Propineb (P771450), which is used as a fungicide.<br>References Sharma, I.M., et. al.: J. Mycology Plant Pathology, 44, 92 (2014); Gupta, R.C., et. al.: Pestology, 37, 43 (2013)<br></p>

<p>Applications rac-3-Hydroxyheptanoic acid-D7 is a labelled analogue of rac-3-Hydroxyheptanoic acid (H943075).<br></p>

<p>Applications 1-Bromoheptane-d15 (CAS# 98195-42-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Dodecyl-d25-amine (CAS# 1219802-72-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Acetate (2-13c, 99%) (cas# 13291-89-9) is a useful research chemical.<br></p>

<p>Applications N,N,N'-Trimethyl-d6-1,3-propanediamine (N,N-dimethyl-d6) (CAS# 1219803-54-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Nonylbenzene-2,3,4,5,6-d5 (CAS# 20216-93-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(Iodoacetylamino)phenol-d4 is an isotope labeled analog of 4-(Iodoacetylamino)phenol (I535250), which is an analytical reagent.<br></p>

<p>Applications 2-Bromoethyl Benzoate-d4 is a labelled analogue of 2-Bromoethyl Benzoate (B810050), a compound used as a reactant in the coupling of challenging heteroaryl halides with alkyl halides via nickel-ctalyzed cross-electrophile coupling.<br>References Hansen, E. C., et al.: J. Org. Chem., 82, 7085 (2017);<br></p>

<p>Applications Labelled analogue of 2-Butanone 2,4-Dinitrophenylhydrazone, a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke.<br>References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>

<p>Applications L-Methionine-13C5 is the isotope labelled analog of L-Methionine, which is an essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.<br>References Benevenga, N.J., et al.: J. Agric. Food Chem., 22, 2 (1974), Fleisher, L.D., et al.: Clin. Endocrinol. Metab., 3, 37 (1974), Meinnel, T., et al.: Biochimie, 75, 1061 (1993),<br></p>

<p>Applications 2,4-Dihydroxybenzophenone-d5 is deuterium labelled of 2,4-Dihydroxybenzophenone (D451780), which is a metabolite of Benzophenone (B204980). Benzophenone can be used to synthesize antihistamines, hypnotics and insecticides.<br>References Li, M.H., et al.: Toxicol. Environ. Chem., 94, 566 (2012); Leon, Z.. et al.: Anal. Bioanal. Chem., 398, 831 (2010); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)<br></p>

<p>Applications N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide-d7 is deuterium labeled N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide (F489575).N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide is an impurity of Furanylfentanyl (F864085), which is an opiod analgesic agent and an analog of Fentanyl (F275000). In addition, N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide may be a useful compound for developing fentanyl-conjugated vaccines by utilizing a protein–drug conjugate that generates an in vivo immunoantagonist, which can minimize the concentration of a specific drug at the sites of action.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bremer, P. T., et al.: Angew. Chem. Int. Ed. 55, 3772 (2016); Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998)<br></p>

<p>Applications 4-Chlorophenyl Phenyl-d5 Ether (CAS# 93951-85-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Uridine-2-13C (CAS# 35803-42-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopropane-2,2,3,3-d4-carboxylic Acid (CAS# 89924-82-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Methylaniline-2,3,4,5,6-d5 is the deuterated form of N-Methylaniline (M288205). N-Methylaniline is used as an additive in gasoline because of its antiknock properties.<br>References Liu, Li-jun, et al.: Huaxue Shiji, 37(1), 53-55, 96 (2015); Qin, Li-xia, et al.: Guangzhou Huagong, 43(8), 138-139, 148 (2015);<br></p>

<p>Applications MCPA Ethyl Ester-D3 is the deuterated form of MCPA Ethyl Ester (M199705), which is a derivative of MCPA, an herbicide.<br>References Elliott, B., et al.: Mutagenesis, 20, 3 (2005), Pfleeger, T., et al.; Environmental Toxicology and Chemistry 30, 455 (2010)<br></p>

<p>Applications 3-Hexanone-2,2,4,4-d4 (CAS# 24588-54-3) is a useful isotopically labeled research compound that is used in mass spectroscopy.<br>References Yeo, A. et.al., J. Am. Chem. Soc., 91,3582-3589,(1969);<br></p>

<p>Applications Tri-n-butyl-d27-amine (CAS# 1219805-78-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-beta,beta,beta-d3-benzene (CAS# 2618-00-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Moisture Sensitive<br>Applications Isotope labelled Allyl Bromide is used as a reagent in the synthesis of Resveratrol derivatives. Resveratrol (R150000) is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.<br> E0<br>References Powell, R.G., et al.: Phytochemistry, 35, 335 (1994), Jeandet, P., et al.: J. Phytopathol., 143, 135 (1995), Mattivi, F., et al.: J. Agric. Food Chem., 43, 1820 (1995); Mulakayala, C. et al.: J. Mol. Graph. Model., 41, 43 (2013);<br></p>

<p>Applications Ethylene Glycol Dipalmitate-d4 is the deuterated version of Ethylene Glycol Dipalmitate (E917565), a component of phase change materials for thermal energy storage.<br>References Aydin, Ahmet A.: Solar Energy Mat. &amp; Solar Cells, 108, 98-104 (2013)<br></p>

<p>Applications 1-Iodopropane-1,1,3,3,3-d5 (CAS# 1219794-94-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Leucine-d3-N-t-BOC H2O (methyl-d3) (CAS# 203645-42-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled B-[1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]boronic Acid is used in the preparation of ALK receptor mediators.<br></p>

<p>Applications n-Decyl-9,9,10,10,10-d5 Alcohol (CAS# 57368-00-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-​1-​Adamantyl-​d15-acetamide is an intermediate in the synthesis of 1-Adamantan-d15-amine (A575823), which is a labeled NMDA-receptor antagonist. Antiviral; antiparkinsonian.<br>References Vernier, V.G., et al; Toxicol. Appl. Pharmacol., 15, 642 (1969); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 12, 1 (1983)<br></p>

<p>Applications Succinic Acid-13C4 is a compound useful in organic synthesis.<br></p>

<p>Applications DL-Alanine-2-d1 (CAS# 31024-91-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4,6-Dichloro-1,3-dinitrobenzene-13C6 (CAS# 335081-12-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bunitrolol-D5 is a labelled analogue of Bunitrolol (B689440).<br></p>

<p>Applications Nicotine metabolite.<br>References Sai, Y. &amp; Gorrod, J.W.: Drug. Metab. Drug. Interact., 12, 93 (1995); Nishida, T. et al.: Org. Magn. Resonance., 13, 434 (1980)<br></p>

<p>Applications 2-Oxopiperazine-3,3,5,5,6,6-d6 (CAS# 1219803-71-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled metabolite of Quetiapine.<br>References McConville, B., et al.: J. Clin. Psychiatry, 61, 252 (2000), Wong, Y., et al.: J. Clin. Psychopharmacol, 21, 89 (2001), Cooper, K., et al.: Eur. J. Clin. Pharmacol., 59, 51 (2003),<br></p>

<p>Applications 1-Bromoheptane-1-d1 (CAS# 38007-40-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(4-cyanophenyl)methanol-d4 is labelled Bis(4-cyanophenyl)methanol (B422852) which is a metabolite of Letrozole (L330100), a nonsteroidal aromatase inhibitor structurally related to Fadrozole.<br>References Bhatnagar, A.S., et al: J. Steroid Biochem. Mol. Biol., 37, 1021 (1990), Pfister, C.U., et al.: J. Pharm. Sci., 83, 520 (1994), Lipton, A., et al.: Cancer, 75, 2132 (1995)<br></p>

<p>Applications n-Butylamine-d11 DCl (CAS# 347841-81-0) is a useful isotopically labeled research compound.<br>Chemical Name: n-Butylamine-d11 DCl (CAS# 347841-81-0) is a useful isotopically labeled research compound.<br></p>