Deuterated Compounds

<p>Applications N-Acetyl-L-alanine-3,3,3-d3 is deuterium labelled form of N-Acetyl-L-alanine (A168065), which is used as a biomarker for prostate cancer.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005);<br></p>

<p>Applications Tetraethoxy-d20-silane (CAS# 272778-10-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled analogue of 2-Butanone 2,4-Dinitrophenylhydrazone, a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke.<br>References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>

<p>Applications 4-Chlorophenyl Phenyl-d5 Ether (CAS# 93951-85-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4,6-Dichloro-1,3-dinitrobenzene-13C6 (CAS# 335081-12-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Iodooctane-1,1-d2 (CAS# 89232-08-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Lactose Monohydrate (L114000), which is used in the synthesis of casing for various methods of oral drug delivery, including dissolving pellets, and long-lasting pellets.<br>References Kamble, M. et al.: Int. J. Pharm. Chem. Biol. Sci., 3, 55 (2013); Hiorth, M. et al.: Int. J. Pharm., 441, 544 (2013);<br></p>

<p>Applications Methocarbamol-d3is deuterium labelled methocarbamol (M225950), which is a muscle relaxant (skeletal).<br>References Topliss, J., et al.: J. Med. Chem., 22, 1238 (1979), Walters, W., et al.: Drug Discov. Today., 3, 160 (1998), Baldi, P., et al.: Bioinformatics, 16, 412 (2000), Kouznetsov, V., et al.: J. Arch. Pharm., 337, 127 (2004),<br></p>

<p>Applications Chlorobenzene-3,4,5-d3 (CAS# 59164-11-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorobenzyl-d6 Chloride (CAS# 1219804-13-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 4-Isocyanatobenzoate-2,3,5,6-d4 (CAS# 1219802-91-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Di-iso-propylbenzene-d18 (CAS# 1398065-59-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Diethylbenzene-d14 (CAS# 1219803-40-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 2-Bromo-2-methyl-d3-propionate-3,3,3-d3 (CAS# 64768-38-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications o-Tolyl-d7 Isocyanate (CAS# 1219802-73-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tridecanoic-2,2-d2 Acid (CAS# 64118-44-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Chlorobutane-d9 (CAS# 175540-77-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexanenitrile-6,6,6-d3 (CAS# 1219805-03-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dicyclohexyl Carbonate-d22 is the isotope labelled analog of Dicyclohexyl Carbonate (D438505); a reagent in the synthesis of colon specific reduction sensitive polymers for pharmaceuticals.<br>References Schacht, E. and Wilding, I.: PCT Int. Appl. WO 9610994 A1 19960418. Apr 18, 1996<br></p>

<p>Applications Adenosine-2-d1 (CAS# 109923-50-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetylglycine-13C2,15N is a labelled derivative of N-Acetylglycine (A178260(P)), which is a derivative of Glycine (G615990). Glycine is a useful intermediate for synthesizing rac 3-O-Methyl DOPA (M303805), which is an impurity of Levodopa.<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003)<br></p>

<p>Applications Tetracosanoic-12,12,13,13-d4 Acid (CAS# 1219794-59-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Iodoacetic Acid-d3 (CAS# 1219799-36-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Propyl Paraben Sulfate (P838355) is the sulfate conjugate of Propyl Paraben (P838285), an antimicrobial agent used in cosmetic products.<br>References Kim, D.H., et al.: Biol. Pharma. Bull., 17, 1326 (1994);<br></p>

<p>Applications Phthalic-13C Acid is an isotope labelled version of Phthalic Acid (P384480), an organic reagent used to synthesize phthalates.<br>References Duchowicz, P.R., et al.: Bioorg. Med. Chem., 16, 7944 (2008);di Luccio, E., et al.: Biochem., 47, 4039 (2008);Lopez, Z., et al.: App. Microbiol. Biotechnol., 78, 739 (2008);Hong, Y., et al.: Toxicol. Lett., 184, 139 (2009)<br></p>

<p>Applications Acetylcholine-1,1,2,2-d4 Bromide is the deuterium labelled form of Acetylcholine Bromide (A172073), which is an endogenous neurotransmitter at cholinergic synapses.<br>References Kobayashi, M., et al.: Adv. Physiol. Sci., 22, 319 (1981); Hulme, C., et al.: Biophys. J., 91, 2371 (2006);<br></p>

<p>Applications 2,3,6-Trimethylphenol-d11 (CAS# 347841-83-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2,4,5-Tetramethylbenzene-d14 (CAS# 15502-50-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Pinacol-d12 is an intermediate in the synthesis of Isotope labelled Tebuconazole (T013002), which is an ergosterol biosynthesis inhibitor present in most pesticide formulations (1,2). Various uptake is observed in plants (3). Drinking water Contaminant Candidate List 3 - CCL 3 as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br></p>

<p>Applications 1-Bromo-3-chloro-5-fluorobenzene-d3 (CAS# 1219805-00-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Diethylbenzene-d14 (CAS# 1219803-64-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Dodecyl Alcohol-d26 (CAS# 38086-03-2) is a useful isotopically labeled research compound. It can be used for neutron spin-echo spectroscopy.<br>References Yamaguchi, T., et.al., J. Phys.Chem.B., 123, 239-246,(2019);<br></p>

<p>Applications 1-Aminonaphthalene-d9 (CAS# 78832-56-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-15N2 (CAS# 369656-71-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-d5 4-Aminobenzoate (CAS# 1219803-76-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications O-Toluoyl Chloride-D7 is the deuterated form of O-Toluoyl Chloride (T536250), which is used in the synthesis if quinolinone compounds as SARS CoV 3CLpro inhibitors. Also used in the synthesis of benzooxaboroles as orally active anti-inflammatory agents.<br>References Sun, Y. et al.: Chin. J. CHem., 31, 1199 (2013); Akama, T. et al.: Bioorg. Med. Chem. Lett., 23, 5870 (2013);<br></p>

<p>Applications n-Hexadecyl-d33 Alcohol (CAS# 284474-73-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Isonipecotic Acid Methyl Ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.<br>References Kim, E.-K. et al.: Yak. Hoechi, 48, 182 (2004); Tanitame, A. et al.: Bioorg. Med. Chem. Lett., 14, 2857 (2004);<br></p>

<p>Applications 2-Chloro-6-ethyl-N,N-dimethylthieno[2,3-d]pyrimidin-4-amine-d6 is the isotope labelled analog of 2-Chloro-6-ethyl-N,N-dimethylthieno[2,3-d]pyrimidin-4-amine (C367635); a useful synthetic intermediate.<br></p>

<p>Applications 4-​Pyridin-​2,​3,​5,​6-​d4-​ol-​d is one of the azepanone derivatives studies as CGRP receptor antagonists.<br>References Liu, J.: PCT Int. Appl. (2010), WO 2010108103 A1 20100923.<br></p>

<p>Applications DL-2-aminobutyric Acid-D5 is an intermediate used in the synthesis of Methyl Ergonovine-d5 Maleate Salt (M304602), which is a labeled metabolite of Methysergide. Semisynthetic ergot alkaloid. Oxytocic.<br>References Mueller, L., et al.: Headache, 37, 437 (1997), de Groot, A.N., et al.: Drugs, 56, 523 (1998)<br></p>

<p>Applications DL-4-Hydroxyphenyl-2,6-d2-alanine-2-d1 (CAS# 73036-42-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Indoramin-d5 (phenyl-d5) (CAS# 57165-41-0) is a useful isotopically labeled research compound. This compound can be used for detecting drugs and their metabolites in biological specimens using gas chromatography-mass spectrometry.<br>References Draffan, G., et.al., Adv. Mass Spec., 6,245-250,(1974);<br></p>

<p>Applications N-Methyl-d3-form-d1-amide (CAS# 110505-55-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Nitrotoluene-2,3,5,6-d4 (CAS# 1276197-16-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Vanillin. Occurs naturally in a wide variety of foods and plants such as orchids; major commercial source of natural vanillin is from vanilla bean extract. Synthetically produced in-bulk from lignin-based byproduct of paper processes or from guaicol.<br>References Jenner, P.M., et al.: Food Cosmet. Toxicol., 2, 327 (1964), Clark, G.S., et al.: Perfum. Flavor., 15, 45 (1990),<br></p>

<p>Applications 1-Propanol-d8 is an intermediate used in the preparation of perdeuterated carboxylates, alcohols and alkyl bromides.<br>References Lipinski, K., et al.: Pol. J. Chem., 67, 667 (1993)<br></p>

<p>Applications Acetylcholine-d13 Bromide (N,N,N-trimethyl-d9; 1,1,2,2-d4) is the deuterium labelled form of Acetylcholine Bromide (A172073), which is an endogenous neurotransmitter at cholinergic synapses.<br>References Kobayashi, M., et al.: Adv. Physiol. Sci., 22, 319 (1981); Hulme, C., et al.: Biophys. J., 91, 2371 (2006);<br></p>

<p>Applications N-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine Carvedilol-d5 is the isotope labelled analog of N-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine Carvedilol (H946145); the impurity A of Carvedilol (C184625) which is a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is also an antihypertensive used in the treatment of congestive heart failure.<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996)<br></p>

<p>Applications Sodium Octanoate-d15 (CAS# 56408-90-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,5-Dinitronaphthalene-d6 (CAS# 1219804-48-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Prednisolamate-D10 is a labelled analogue of Prednisolamate (P703715).<br></p>

<p>Applications 2-Bromo-4'-fluoroacetophenone-2',3',5',6'-d4 (CAS# 1219803-30-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4-Dimethyl-d6-nitrobenzene (CAS# 1398065-58-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,4-Dichlorotoluene-2,5,6-d3 (CAS# 1219795-29-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Desacetyl Diltiazem-d4 Hydrochloride is the labeled analogue of Desacetyl Diltiazem Hydrochloride (D289335), a metabolite of Diltiazem Hydrochloride (D460620), a calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).<br>References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987); Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990); Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991); Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971); Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998); Hansson, L., et al.: Lancet, 356, 359 (2000)<br></p>

<p>Applications L-Leucine-3,3-d2 (CAS# 362049-59-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N is an isotope labelled spin-labelling compound.<br></p>

<p>Applications Ethyl (±)-2-Bromopropionate-3,3,3-d3 (CAS# 1398066-14-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Pentyl Alcohol-d12 (CAS# 158778-85-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyproheptadine Hydrochloride-d3 is the isotope labelled analog of Cyproheptadine (C989200, HCl,H2O); a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Also a 5-HT2/5-HT1C serotonin receptor antagonist, H1 histamine receptor antagonist, and antipruritic.<br>References Marchei, E., et al.: J. Pharm. Biomed. Anal., 41, 1633 (2006); de-Benedictis, F., et al.: Allergy, 63, 1395 (2008); Feas, X., et al.: J. Pharm. Biomed. Anal., 50, 1044 (2009); Yu, C., et al.: Talanta, 2011, 83, 1376 (2011)<br></p>