Deuterated Compounds

<p>Applications tert-Butyl Methyl Ether-d12 (CAS# 284487-64-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-Ropivacaine-d7 (propyl-d7) (CAS# 1392208-04-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Glycerol (G598400) is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.<br>References Bartsch, W., et al.: Arzeim.-Forsch., 26, 1581 (1976),<br></p>

<p>Applications Hydrocinnamic-alpha,alpha-d2 Acid (CAS# 19136-97-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,5-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one-d3 is the deuterated version of 2,5-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one (D480165), which is an impurity of Alosetron (A575500) that is a serotonin 5HT3 receptor antagonist, used in treatment of irritable bowel syndrome.<br>References Camilleri, M., et al.: Lancet, 355, 1035 (2000); Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002); Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003); Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006); Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007);<br></p>

<p>Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications (1,2,5,6-Tetramethyl-d6)naphthalene is the labeled analogue of 1,2,5,6-Tetramethylnaphthalene (T303675), a polycyclic aromatic hydrocarbon that has been found in petroleum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Forster, P.G., et. al.: J. Chromatogr., 483, 384 (1989)<br></p>

<p>Applications 3-Hydroxy-2-naphthoic Acid-d6 is an intermediate used in the synthesis of Pamoic Acid-d10 (P173502), which is a labelled Pamoic Acid. Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases. Enzyme replacement therapy in pancreatic enzyme deficiency.<br>References Fonge H., et al.: Bioconjugate Chem., 18, 1924 (2007), Mayr, G.W., et al.: J. Biol. Chem., 282, 35424 (2007); Zhao, P. et al.: Mol. Pharmacol., 78, 560 (2010); Dorjsujen, D. et al.: Nuc. Acids Res., 37, e128 (2009);<br></p>

<p>Applications Ethyl N-n-Butyl-d9-carbamate (CAS# 1276197-24-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluoro-1,3-dioxolan-2-one-d3 is the labeled version of 4-Fluoro-1,3-dioxolan-2-one (F591523)<br></p>

<p>Applications (2,4-Dichlorophenoxy-d3)acetic-d2 Acid (CAS# 352438-69-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopentane-1,1-d2 (CAS# 77734-75-9) is a useful isotopically labeled research compound.<br></p>