Deuterated Compounds

<p>Applications Estrone-2,4-d2 (CAS# 350820-16-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 8-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. This is the labeled analog.<br>References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999); Sangaiah, R., et al.: Poly. Aro. Comp., 11, 283 (1996);<br></p>

<p>Applications N-Boc-(p-Aminobenzoyl)-L-glutamic Acid Dimethyl Ester-13C5 is an intermediate used in the synthesis of Folic Acid-13C5 (F680303), which is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>

<p>Applications 4-Bromomethcathinone-D3 hydrochloride is a labelled analogue of 4-Bromomethcathinone hydrochloride (B686080). 4-Bromomethcathinone is part of a family of synthetic cathinone compounds called aminopropiophenones (which have high potential for abuse). Aminopropiophenones have potential psychoactive effects, can lead to death, and are labelled as highly controlled substances in many countries.<br>References Foley, K. &amp; Cozzi, N.: Drug Dev. Res., 60, 252 (2003); Mas-Morey, P., et al.: J. Pharm. Pract., 26, 353 (2013); Penders, T., et al.: Gen. Hosp. Psych., 34, 647 (2012); Spiller, H., et al.: Clin. Toxicol., 49, 499 (2011)<br></p>

<p>Applications Ursodeoxycholic Acid-24-13C is the labeled compound of Ursodeoxycholic Acid (U850000). It is used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.<br></p>

<p>Applications 2-Ethyl-1-hexanol-D5 is an intermediate in the synthesis of Alexidine-d10 Dihydrochloride (A525002), which has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.<br>References Coburn, R.A., et al.: J. Med. Chem., 21, 8, 829 (1978), Takayama, K., et al.: J. Biol. Chem., 269, 2241 (1994), Faure, P., et al.: Biochimie, 86, 411 (2004),<br></p>

<p>Applications 3,3-Dimethyl-2-butanol-d3 is an isotopic analog of 3,3-Dimethyl-2-butanol (D471480), a reagent used in the synthesis of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists. 3,3-Dimethyl-2-butanol is also used in the preparation of dihydropyrrole derivatives containing N-sulfanyl, sulfinyl, and sulfonyl moieties which have insecticidal activity.<br>References Ito, M., et al.: Bioorg. Med. Chem., 11, 489 (2003); Micheli, F., et al.: Bioorg. Med. Chem., 11, 171 (2003)<br></p>

<p>Stability Easily Oxidized<br>Applications 1-Bromo-4-nitrobenzene-d4 (cas# 350820-19-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Pyridine-4-d1 (CAS# 10259-15-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Vinblastine-d3 Methiodide is the labeled analogue of Vinblastine Methiodide (V314015), an adduct of Vinblastine (V314000), an antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.<br>References Dorman, D.E., Paschal, J.W.: Org. Magnetic Resonance, 8, 413 (1976); Lu, C., et al.: Cancer Research, 39, 3575 (1979); Gobbi, P.G., et al.: J. Clin. Oncol., 14, 527 (1996); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs. Excip., 21, 611 (1992)<br></p>

<p>Applications D,L-Carnitine-d3 Chloride is the isotope labelled analog of D,L-Carnitine Chloride (C184100); a vitamin (enzyme cofactor). It is an essential cofactor of fatty acid metabolism and is required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney with the highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications 5-Bromo Pentane-1,1,1,2,2,3,3,4,4-d9 is a isotope labeled building block.<br></p>

<p>Applications Ethyl-1-d1 Alcohol (CAS# 1624-36-8) is a useful isotopically labeled research compound.<br></p>