Deuterated Compounds

Applications Cyclopropylmethanol-d3, is a labeled analogue of Cyclopropylmethanol (C988605), which is used to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A, inhibitors against phosphodiesterase 3 (PDE3). Also used in the synthesis of benzodiazapin-2-ones
References Hu, E. et al.: Bioorg. Med. Chem. Lett., 22, 6938 (2012);

Applications Bis(m-cresyl) o-Cresyl Phosphate-d7 is labelled Bis(m-cresyl) o-Cresyl Phosphate (B419220), an isomer of Tricresyl phosphate (TCP) which is used as an anti-wear additive in aircraft turbine engine oil.
References De Nola, G., et al.: J. Chrmoat. A, 1200, 211 (2008)

Applications Isotope labelled Glycerol (G598400) is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.
References Bartsch, W., et al.: Arzeim.-Forsch., 26, 1581 (1976),

Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.

Applications Ethyl N-n-Butyl-d9-carbamate (CAS# 1276197-24-0) is a useful isotopically labeled research compound.

Applications Fenthoxon (Dimethylphosphate-d6) is derived from Methyl Alcohol-d4 (M265107), which is the labeled analog of methyl alcohol, a common laboratory solvent used primarily in spectroscopic techniques (UV/VIS, NMR, IR). Also, it is a major metabolite of Fenthion (FEN). It is used as organophosphorus pesticides.
References Dawson, D.M. et al.: Phys. Chem. Chem. Phys., 15, 919 (2013); Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),

Applications N-Acetylpiperazine-d4 is labelled N-Acetylpiperazine-d4 which was used to prepare (aryl)sulfanyltriazoles with HIV-1 non-nucleoside reverse transcriptase inhibiting activities. It was also used to synthesize diphenylpyrazolecarboxamides as heat shock protein chaperone inhibitors and anticancer agents.
References Wang, Z., et al.: Bioorg. Med. Chem. Lett., 16, 4174 (2006); Brough, P., et al.: J. Med. Chem, 51, 196 (2008)

Applications Cardiogenol C-d4, Hydrochloride is an isotope labelled analog of Cardiogenol C, Hydrochloride. Cardiogenol C, Hydrochloride is a potent, cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.
References Wu, X., et al.: J. Am. Chem. Soc., 126, 1590 (2004)

Applications DL-Lysine-4,4,5,5-d4 2HCl (CAS# 284664-88-6) is a useful isotopically labeled research compound.

Applications 1-Chlorooctane-d17 (CAS# 1219803-93-6) is a useful isotopically labeled research compound.

Applications Thymine-alpha,alpha,alpha,6-d4 Glycol (mixture of diastereomers) (CAS# 132523-94-5) is a useful isotopically labeled research compound.

Applications 3-Pyridylcarbinol-d6 (cas# 1189493-62-6) is a compound useful in organic synthesis.