Deuterated Compounds

Applications Suberyl glycine-d4 is deuterium labelled Suberylglycine (S688755), which is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).
References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000); Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009); Scalbert, A., et al.: Metabolomics, 5, 435 (2009)

Applications n-Dipropylamine-d4 Hydrochloride (cas# 1329834-71-0) is a compound useful in organic synthesis.

Applications 2-Chloronaphthalene-d7 (CAS# 93951-84-9) is a useful isotopically labeled research compound.

Applications Labelled N-nitrosopiperazine derivative; shows strong nasal carcinogenicity and genotoxicity after low dose inhalation.
References Sabadie, N., et al.: Cancer Res., 40, 119 (1980), Kuchenmeister, F., et al.: Toxicol. Lett., 88, 29 (1996), Mathison, B., et al.: Mutat. Res., 380, 77 (1997),

Applications Benzyl-alpha,alpha-d2 Alcohol (CAS# 21175-64-4) is a useful isotopically labeled research compound.

Applications Cefepime-D8 sulfate is a labelled analogue of Cefepine sulfate, a cephalosporin that has antibacterial effects against Gram-positive and Gram-negative bacteria. Cefepime sulfate is used to treat mild to severe bacterial infections.
References Neu, H.: Am. J. Med., 100, 68S (1996); Sanders, C.: Clin. Infect. Dis., 17, 369 (1993); Sanders, W., et al.: Clin. Infect. Dis., 23, 454 (1996); Yahav, D., et al.: Lancet Infect. Dis., 7, 338 (2007)

Applications Cyclohexanol-d12 (CAS# 66522-78-9) is a useful isotopically labeled research compound.

Applications Emamectin-d3 is deuterium labeled emamectin, a soluble derivative of avermectin and used as parasiticide and insecticide. Emamectin activates glutamate-gated chloride channels.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Xu X., et al.: Biochem Biophys Res Commun 473, 795 (2016); Lumaret, J. P., et al.: Curr Pharm Biotechnol. 13, 1004 (2012)

Applications Butyric-2,2-d2 Acid (CAS# 19136-92-6) is a useful isotopically labeled research compound.

Applications 1,3-Diphenyl-d10-urea is labelled 1,3-Diphenyl-urea which is a cytokinin compound present in fruit and vegetables. It is metabolized by a moderate halophilic Marinobacter sp.
References Sørensen, S., et al.: FEMS Microbiol. Lett., 213, 199 (2002); Campillo, N., et al.: Talanta, 116, 376 (2013)

Applications Bisphenol AF-d4 is the isotope labelled analog of Bisphenol AF (2,2-Bis-(4-hydroxyphenyl)hexafluoropropane). 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane (B447290) acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor ERα. It is a full agonist for the estrogen receptor.
References Matsushima, A. et al.: Environ. Health, Perspect. 118, 1267 (2010)

Applications Labelled Formic Acid is used to improve NMR profiling of amino metabolites in biofluids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ye, T. et al.: Anal. Chem., 82, 2303 (2010); Gowda, G.A., Anal. Chem., 82, 8983 (2010);

Applications Labelled Hydrazine Hydrate, used as a reactant in the cyclizations of pyridinones. It is also used in the study of nanocrystal semiconductors, participating in the functionalization and passivation of surface states.
E0
References Smolyar, N. et al.: Rus. J. Org. Chem., 44, 1205 (2008); Traub, M. et al.: J. Am. Chem. Soc., 130, 955 (2008);

Stability Hygroscopic
Applications (±)-Albuterol-d3 (3-hydroxymethyl-d2; alpha-d1) (CAS# 1219798-60-3) is a useful isotopically labeled research compound.

Applications PyroPyronaridine-13C2 , d4 Tetraphosphate Salt is the labeled analogue of Pyronaridine (P997640), an antimalarial drug.
References Lee, D.W., et. al.: B. Kor. Chem. Soc., 35, 521 (2014)

Applications 4-(2-(4-Chlorobenz-d4-amido)ethyl)phenyl 4-Chlorobenz-d4-oate is an intermediate in the synthesis of Bezafibrate-d4 (B341002), a labeled antilipemic agent.
References Zimmerman, R., et al.: Atherosclerosis 29, 477 (1978), Monk, J.P., et al.: Drugs, 33, 539 (1987)

Stability Light and temperature Sensitive
Applications 2,2-Dichloroacetic Acid-1-13C is derived from Barium Carbonate-13C (B118672), which is a stable Barium Carbonate isotope used for studies on drug metabolism.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Horie, M. et al.: Yakug. Zas., 97, 805 (1977);

Applications 1,3-Propylene-d6 Thiourea (CAS# 1219802-05-7) is a useful isotopically labeled research compound.

Applications Labelled Physcion. A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.
References Thiericke, R., et al.: Nat. Prod. Rep.,10, 265 (1993), Lin, C., et al.: J. Nat. Prod., 58, 1934 (1995), Julia, S., et al.: J. Biotechnol., 124, 690 (2006), Wang, W., et al.: J. Antibiot., 60, 603 (2007),

Applications Hexanoic-d11 Acid acts as a reagent in the synthesis of per-deuterated alkyl amines for preparation of deuterated organic pyromellitamide gelators.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yepuri, N. R.; Tetrahedron Lett., 54, 2538 (2013)