Deuterated Compounds

Applications Labelled Sodium Cyanoborohydride is a commonly used as a reagent in the reductive amination of aldehydes and ketones and in the reductive alkylation of amines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hsu, J. et al.: J. Am. Soc. Mass Spec., 17, 194 (2006); Ducrocq, C. et al.: J. Label. Comp. Radiopharm., 22, 61 (1985);

Applications Ammonium-15N hydroxide Solution is a solution prepared from ammonium-15N sulfate for studying fertilizer use efficiency and is an important fertilizer for soil fertilization of the sugarcane crop in Brazil.Ammonium-15N hydroxide Solution is also used in the preparation of isotope-labeled oligonucleotides for their use in NMR studies of protein-DNA complexes.Ammonium-15N hydroxide Solution is the 15N-labeled compound for A634020, which is used in numerous household cleaning agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bendassolli, Jose Albertino., Scientia Agricola (Piracicaba, Brazil), 59, 595-603, (2002)Kellenbach, E. R., Nucleic Acids Research, 20, 653-7, (1992)Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013)

Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);

Applications 4-Dimethylaminobutyric Acid Hydrochloride-d6 is an intermediate in synthesizing 4-​(Dimethyloxidoamino)​butanoic Acid-d6 Hydrochloride (D447162), which is a labelled form of 4-​(Dimethyloxidoamino)​butanoic Acid (D447160). 4-​(Dimethyloxidoamino)​butanoic Acid is a metabolite of Lauramine Oxide (L178530), which is a frequently used amine oxide surfactant. It is strongly hydrophilic , and it forms normal micelles and normal liquid crystalline phases. 4-Dimethylaminobutyric Acid Hydrochloride-d6 is also a labelled analogue of 4-Dimethylaminobutyric Acid Hydrochloride (D456545), which acts as a reagent for the design, synthesis and in the biological evaluation of novel water-soluble prodrug of Docetaxel with amino acid as linkers.
References Kocherbitov, v., et al.: J. Molec. Struct.: Theochem., 808, 111 (2007); Kocherbitov, v., et al.: J. Phys. Chem. B., 110 (27), 13649 (2006); Turan, T.S., et al.: Xenobiotica, 11, 447 (1981); Ma, H., et al.: Chem. Biol. Drug Des. 88, 363 (2016);

Applications Farnesyl Pyrophosphate Triammonium Salt-13C3 is labelled Farnesyl Pyrophosphate Triammonium Salt (F102470) which is an isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.
References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),

Applications Substrate for alcohol dehydrogenase
References Burkhard, P., et al.: J. Mol. Biol., 295, 953 (2000), Ferreira, A., et al.: J. App. Microbiol., 91, 67 (2001), Johnson, B., et al.: J. Comp. Neurol., 502, 468 (2007),

Applications Glutaronitrile-d6 (cas# 1346598-53-5) is a compound useful in organic synthesis.

Applications 2-Amino-4,6-dichloropyrimidine-13C2 (cas# 1346605-11-5) is a compound useful in organic synthesis.

Applications O-TBS 2'-Deoxy-N-methyl-cytidine-d3 is an intermediate used in the synthesis of 2'-Deoxy-N-methyl-cytidine-d3 (D242412), which is the labelled form of 2'-Deoxy-N-methyl-cytidine (D242410). 2'-Deoxy-N-methyl-cytidine is a nucleotide derivative used as an analytical reagent.
References Dupret, D.: Biomed. Health. Res., 23(Human Genome Analysis), 244-255 (1998)

Applications An intermediate for the synthesis of Tamoxifen.
References Ruenitz, P.C., et al.: Biochem. Pharmacol., 34, 2807 (1985), Gilbert, J., et al.: J. Med. Chem., 40, 1104 (1997), Lashley, M.R., et al.: Bioorg. Med. Chem., 10, 4075 (2002),

Applications N,N-Diisopropyl-3-(2-methoxy-5-methyl-phenyl)-3-phenylpropylamide-d14 (cas# 1795013-34-1) is a compound useful in organic synthesis.

Applications (S)-1-Boc-3-hydroxypiperidine-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Applications A deuterated intermediate in the synthesis of the metabolite of Terbinafine, an orally active, antimycotic allylamine related to naftifine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Pyridine-N-oxide-d5 (cas# 19639-76-0) is a compound useful in organic synthesis.

Applications Reproduction of Sindbis virus strains sensitive and resistant to 1-adamantanecarboxamide.
References Erice, A., et al.: N. Engl. J. Med., 320, 289 (1989), Andronova, V.L., et al.: Bull. Exper. Bio. Med., 129, 74 (2000).

Applications (R)-1-Tosyloxy-2,3-propanediol-d2 is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Applications 2-(tert-Butylamino)-4-chloro-6-cyclopropylamino-1,3,5-triazine-d9 (cas# 1189419-70-2) is a compound useful in organic synthesis.

Applications An intermediate in the preparation of deuterated cytidine derivatives
References Chamorro, C., et al.: Bioorg. Med. Chem. Lett., 11, 3085 (2001), Bornemann, B., et al.: Bioorg. Med. Chem., 14, 6235 (2006), Desbouis, D., et al.: J. Med. Chem., 51, 6689 (2008),

Applications 2-Amino-5-chlorobenzophenone Oxime-d5 is an intermediate in synthesizing N-Demethyl Chlordiazepoxide-d5 (D230827), a deuterium labelled analogue of N-Demethyl Chlordiazepoxide (D230825), which is the main metabolite of anxiolytic drug Chlordiazepoxide (C327050).
References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978); Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002)

Applications 2-Pyridineacetic Acid-d6 Ethyl Ester is an labelled analogue of 2-Pyridineacetic Acid (P991750), a compound used often in nucleophilic substitution.
References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),