Deuterated Compounds

Applications Intermediate in the production of labelled Folic Acid
References Jones, P., et al.: J. Med. Chem., 41, 3062 (1998), Uto, Y., et al.: Bioorg. Med. Chem., 16, 6042 (2008),

Applications 5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine-13C,15N2 >95% is a compound useful in organic synthesis.

Applications 1,4-Di(bromomethyl)benzene-d4 (cas# 74903-75-6) is a compound useful in organic synthesis.

Applications 2-(n-Butyl-d9-amino)-4-chloro-6-cyclopropylamino-1,3,5-triazine (cas# 1189997-37-2) is a compound useful in organic synthesis.

Applications (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone-D3 is an intermediate in the synthesis of (S)-3-Hydroxy-2-methylpropanoic Acid-d3 sodium salt (H997291), which is the labelled version of 3-hydroxy-2-methyl-Propanoic acid sodium salt (CAS# 1893416-17-5), a useful building block used in the synthesis of aminotriazine derivatives.
References Du, Z.; et al.: WO 2016049211 (2016).

Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N-(methyl-d3)amine (cas# 1189957-44-5) is a compound useful in organic synthesis.

Applications 2-(Acetylamino)butanoic Acid-d5 is an intermediate of Isotope labelled L-2-Aminobutyric Acid (A602930) Receptor antagonist.
References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995),

Applications Glycine-13C2,15N p-Toluenesulfonate is a by-product of an intermediate during the synthesis of m-Hydroxyhippuric Acid-13C2, 15N (H943127), a labelled m-Hydroxyhippuric Acid (H943125) which is a metabolite of caffeic and chlorogenic acids in human.
References Booth, A., et al.: J. Biol. Chem., 229, 51 (1957); Gonthier, M., et al.: Biomed. Pharmacother., 60, 536 (2006)

Applications Cyclopropylmethanol-d4 is an isotope labelled reagent used in the addition of labelled cyclopropane.

Applications labelled Wittig reagent.
References Tsuchida, K., et al.: J. Med. Chem., 49, 80 (2006),

Applications 1-Ethoxyethanimine-D3 Hydrochloride is an intermediate in the synthesis of Secnidazole-d3 (S225003), which is a labelled Secnidazole (S225000). Analog of Metronidazole. Antiamebic. Antiprotozoal (Trichomonas).
References Cosar, C., et al.: Arzneim.-Forsch., 16, 23 (1966), Videau, D., et al.: Br. J. Vener. Dis., 54, 77 (1978), Symonds, J., et al.: J. Antimicrob. Chemother., 5, 484 (1979),

Applications Labelled Doxylamine intermediate.
References Rennison, D., et al.: Bioorg. Med. Chem., 15, 2963 (2007),

Applications Tri-n-butylallylphosphonium Bromide-d5 is isotope labelled intermediate in the synthesis of quaternary phosphonium reversible inhibitors of cholinesterases.
References Basova, N. E., et al.: J. Evo. Biochem. Physiol., 47, 420 (2011);

Applications 2-(2-Formamidothiazol-4-yl)acetic Acid-13C,15N2 is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.
References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Stability Air and Moisture Sensitive
Applications Dangerous for the environment.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Reagent used to make labelled Catechol.

Applications Acetophenone-13C8 is an intermediate in synthesizing Mandelic Acid-13C8 (M162523). It is a C13 labelled Mandelic Acid which is used as an antiseptic (urinary). It is also used as a short-term exposure biomarker in urine from styrene exposed workers.
References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007); Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009); Fustinoni, S., et al.: Toxicol. Lett., 192, 40 (2010)

Applications Ethyl Isobutyrylacetate-d6 (cas# 1216475-83-0) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N-(4-Nitrobenzoyl)-D-serine Quinine Salt is an intermediate used in the synthesis of D-Serine-2,3,3-d3 (S270977), which is derived from 2-Chlorobenzyl Chloride (C364225), which is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity.
References Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015); Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)