Deuterated Compounds

Applications Pemetrexed-13C5 Disodium Salt, is the labeled analogue of Pemetrexed Disodium (P219500), used as Antineoplastic agent.
References McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998), John, W., et al.: Cancer, 88, 1807 (2000), Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000),

Applications Labelled Sulfamonomethoxine. Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia.
References Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995)

Stability Hygroscopic
Applications L-3-(4-Hydroxy-3-methoxy-d3-phenyl)alanine (CAS# 586954-09-8) is a useful isotopically labeled research compound.

Applications Diethanolamine similar to triethanolamine (T775580) is used as a surfactant. It also has the potential to be a corrosion inhibitor by means of chemisorption. This is the labelled analog.
References Bhajiwala, H.M et al.: Bull. Electrochem., 17, 441 (2001); Yu, J. et al.: Thin. Solid. Films., 379, 7 (2000);

Applications rac-3-Hydroxypentanoic acid-D3 is a labelled analogue of rac-3-Hydroxypentanoic acid (H949470), a useful synthetic intermediate that is used in the fine chemical and pharmaceutical industries.
References Kuhara, T. & Matsumoto, I.: Biomed. Mass Spec., 7, 424 (1980); Rinaldo, P., et al.: Perspect. Inherit. Metabol. Dis., 7, 57 (1987); Tseng, H., et al.: Microb. Cell Fact., no Vol. given, 96 (2010)

Applications Labelled 4-Nitrophenol (N496945). Used in the manufacturing of pharmaceuticals, fungicides, dyes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Butyric-3,3,4,4,4-d5 Acid (CAS# 156779-02-1) is a useful isotopically labeled research compound.

Stability Air sensitive, Material darkens in storage with no loss in purity
Applications Isotope labelled Aniline (A662475), which is used in the manufacture of dyes, medicinals, resins, varnishes, perfumes, as a vulcanizing rubber or even as a solvent (1,2). Hazardous and noxious substance which affects the early life stages of marine animals (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Cunha, I. et. al.: Environ. Sci. Pollut. Res. Int. 2017 Mar 10.2. Zhang, X. et al.: Synthesis. 2013 45(10): 1357-13633. Barkov, A. et al.: Russ. Chem. Bull. 2012. Aug:61(8) pp1564-9

Applications Tetraphenylstannane-d20 is an isotope labelled organometallic compound and an intermediate in the synthesis of isotope labelled Chlorotriphenylstannane (C4222525), a compound used in the synthesis of nano particles that bears triamide ligands.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Isotope labelled β-Alanine is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of dihydrouracil (D449990) and carnosine. β-Alanine is also the rate-limiting precursor of carnosine, as a result supplementation with β-alanine increases the concentration of carnosine in muscles.

Applications Phenoxy-d5-acetic Acid (cas# 154492-74-7) is a compound useful in organic synthesis.

Applications Gallic Acid-d2 is the labelled analogue of Gallic acid (G188978) which is a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities.
References Yen, G. et al.: Food Chem., 79, 307 (2002); Chen, C. et al.: Mol. Nutrit. Food Res., 51, 962 (2007); Kratz, J. et al.: Mem. Inst. Oswaldo Cruz, 103, 437 (2008); Osborne, L. et al.: Infect. Immun., 33, 769 (1981);

Applications Labelled Creatinine. The end product of creatine catabolism. Normal constituent of urine. Also found together with creatine in muscle tissues and blood. Occurs in all soils and in grain seeds and other vegetable matter. Has been found in certain fish and in crab meat extract.
References Folin, et al.: J. Biol. Chem., 17, 463 (1914),

Applications Anthracene-d10 is an isotope labelled analogue of Anthracene (A678400), an polycyclic aromatic hydrocarbon found readily as an component in coal tar. Anthracene is also used in the preparation of various dyes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Norfloxacin-d5 is deuterium labeled Norfloxacin (N681000), a synthetic fluoroquinolone and an antibacterial agent. Norfloxacin can be used to treat urinary tract infections.
References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980), Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981), Holmes, B., et al.: Drugs, 30, 482 (1985),

Applications 2-Benzothiazolethiol-d4 (cas# 1346598-64-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Butyric-4,4,4-d3 Acid (CAS# 36789-14-7) is a useful isotopically labeled research compound.

Applications Isotope labelled N-Nitrosodiphenylamine (N525775), which is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211

Stability Hygroscopic
Applications Myristoyl-L-carnitine-d3 Hydrochloride is labelled Myristoyl-L-carnitine Hydrochloride (M884745), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.
References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications L-Lysine-3,3,4,4,5,5,6,6-d8 Dihydrochloride, is the labelled L-Lysine, a naturally occurring amino acid which is used in the labelling of human bone marrow mesenchymal stem cells for analysis.
References Rocha, B. et al.: J. Prot. Res., 11, 5350 (2012); Kumar, D. et al.: Polym. J., 45, 160 (2013);

Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.
References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications A labelled metabolite of the pesticide Glyphosphate (G765000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Siehl, D.L. et al.: J. Biol. Chem., 282, 11446 (2007); Env. Prot. Agen. EPA: Fed. Reg., 74, 67129 (2009);

Applications 4-Aminobutyric-2,2-d2 Acid (CAS# 67910-98-9) is a useful isotopically labeled research compound.

Applications Isotope labelled 24 Bisphenol S (B519620) is a material used in thermal printing. 24 Bisphenol S is also used in the development of black leuco dyes.
References Shima, H. et al.: J. Imag. Sci. Technol., 54, 020502 (2010)

Applications 4-Hydroxybenzophenone-d4 is an isotopic analog of 4-Hydroxybenzophenone (H829305), a metabolite of benzophenone (B204980).
References Stocklinski, A. et al. Life Sciences 26, 365(1980)

Applications N-Nitrosodiethylamine-d10 is a labelled form of N-Nitrosodiethylamine (N525465) which is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Oda, Y., et al.: Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 584, 1 (2005); Yamazaki, H., et al.: Carcinogenesis, 13, 1789 (1992);Chem. and Eng. News, p.5, Feb. 25, 2019

Applications Dibutyldiethyltin belongs to a class of organotin compounds that are commonly used as pesticides and fungicides and as plastics additives. Diphenyltin Dichloride is an environmental pollutant with potential antitumor activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Khosa, R.L. et al.: Sci. Cult., 35, 637 (1969); Hamasaki, T. et al.: Mutat. Res. Gen. Toxicol. Test., 300, 265 (1993); Peng, J.: Yaox. Xueb., 29, 406 (1994);

Applications 2-Naphthol-d7 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)

Applications 3-Hydroxybutyrylcarnitine-d3 is labelled 3-Hydroxybutyrylcarnitine (H830900) which is a reagent used to study acylcarnitine profile in thyroid disease.
References Wong, S., et al.: Clinical Biochem., 46, 180 (2013); Alu, F., et al.: Heredity, 110, 253 (2013); Adam, B., et al.: Clinical Biochem., 44, 1445 (2011)

Applications Cinnamic Acid-13C3 is the labelled analogue of Cinnamic Acid which is rac-form of trans-Cinnamic Acid (P336185) that is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines and N-methylation of amides and O-methylation of carboxylic acids.
References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);

Stability Hygroscopic
Applications Isotope labelled N-Acetyl-S-(2-cyanoethyl)-L-cysteine Ammonium Salt is a metabolite of Acrylonitrile (AN) and acrylamide (AM). Are commonly used in the synthesis of plastics and polymers.
References van Bladeren, P., et al.: Drug Metab. Dispos., 9, 246 (1981), Guengerich, F., et al.: Chem. Res. Toxicol., 4, 168 (1991),

Applications Mepanipyrim Phenyl-d5 is deuterium labelled Mepanipyrim (M223600).Mepanipyrim (M223600) is an anilinopyrimidine fungicide which have been used in the management of fungal diseases in strawberries.
References Tetada, M., et al.: Toxicol. Appl. Pharmacol., 154, 1 (1999); Hauke, K., et al.: Commun. Agri. Appl. Biol. Sci., 69, 743 (2004);

Applications 4-Nitrobenzoic Acid-d4 is labelled 4-Nitrobenzoic Acid (N493550) which is used in the synthesis of anti-Trypanosoma cruzi agents in the treatment of chagas disease.
References Palace-Berl, F. et al.: Bioorg, Med. Chem. Lett., 21, 5395 (2013); Zhou, L. et al.: J. Med. Chem., 56, 796 (2013);

Applications A labelled form of Pirimicarb (P508768) which is a pesticide which is useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tsuchiyama, T.; et al.: Journal of Chromatography A, 1524, 233 (2017).

Stability Volatile
Applications N-Hexane (D14, 98%) (cas# 21666-38-6) is a useful research chemical.

Stability Air sensitive
Applications Reagent used in the preparation of labelled non-steroidal anti-inflammatory drugs, dyes and pesticides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cauchon, D., et al.: J. Appl. Toxicol., 17, 397 (1997),

Applications Indole-4,5,6,7-d4 is a labelled analogue of Indole (I577320), which can be used in perfumes and in the synthesis of tryptophan. It is also an intermediate in synthesizing Indoleacetic Acid-13C6 (I577343), which has the potential to be used in anti-cancer therapy in conjunction with horseradish peroxidase (HRP).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kawano, T. et al.: Gen. Hypo. 60, 664 (2003);

Applications A deuterated acyclic nucleotide.

Applications Di-n-decyl Phthalate-3,4,5,6-d4 (CAS# 1276197-18-2) is a useful isotopically labeled research compound.

Applications Dihexylphthalate-d4 is an labeled analog of Dihexylphthalate (B185430), which is a phthalic ester, which is used as a plasticizers for vinyl plastics. Phthalates may be associated with reproductive toxicity in humans and animals.
References Saido, K., et al.: ?J. Am. Oil Chem. Soc 61, 945 (1984); Foghmoes, S., et al.: J. Eur. Ceram. Soc. 36, 3441 (2016); Przybyli?ska, P. A. and Wyszkowski, M.: Ecol. Chem. Eng., S 23,347 (2016)

Applications 3-Nitrobiphenyl is a nitrated benzene metabolite found in the bone marrow of B6C3F1 mice treated with benzene. 3-Nitrobiphenyl displays toxic effect on Tetrahymena pyriformis, Porphyromonas gingivalis, Selenomonas artemidis, and Streptococcus sobrinus.
References Laszlo, T. & Beteringhe, A.: QSAR Combinatorial Sci., 25, 944 (2006); Mintz, C. et al.: QSAR. Combinatorial Sci., 25, 912 (2006); Chen, K. et al.: Chem. Res. Toxicol., 17, 370 (2004)

Applications Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)

Applications Isotope labelled Ethyl Caproate is used in the synthesis of novel EP2/EP4 dual agonist of γ-lactam prostaglandin E1 analogs. Also used as a chemical reagent in the synthesis of PPARα antagonists in the treatment of metabolic diseases.
References Kambe, T. et al. Bioorg. Med. Chem. Lett., 22, 396 (2012); Ammazzalorso, A. et al.: Bioorg. Med. Chem. Lett., 21, 4869 (2011);

Applications Isotope labelled Tebufenozide (T013200), which is a synthetic nonsteroidal ecdysone agonist used in pesticide formulations (1) that causes premature molting; novel insect growth regulator (2,3,4) specific to lepidopteran species. Drinking water Contaminant Candidate List 3 (CCL3) as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Jordan TB, et al.: Anal Bioanal Chem. 2009 Aug;394(8):2257-66.2. Vianna UR. Et al.: Ecotoxicology. 2009 Feb;18(2):180-6.3. Rose, G. et al. Food. Chem. 2009 Dec;117(4) pp634-6404. Wang, J. et al.: J. Agric. Food Chem. 2009 Mar 25;57(6):2162-73.

Applications Diphenyl-2,2',4,4',6,6'-d6-amine (CAS# 99234-91-0) is a useful isotopically labeled research compound.

Applications N-Ethyl-2-hydroxysuccinimide-d5 is the isotope labelled analog of N-Ethyl-2-hydroxysuccinimide (E919180); a metabolite of N-ethyl-2-pyrollidone (NEP) which is a frequently used industrial solvent shown to be embryotoxic in animal experiments.
References Schindler, B.K., et al.: Anal. Chem., 84, 3787 (2012)

Applications Labelled Benzylparaben. An antimicrobial agent used in cosmetic products.
References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),

Applications 5-Oxo-DL-proline-d5 is a labelled cyclized derivative of L-Glutamic Acid (G596960). The pyroglutamate core has potential application for synthesis of novel anti-bacterials.
References Mischo A. et al.: ChemBioChem., 13, 1421 (2012); Angelov P. et al.: Org. Biomol. Chem.: 10, 3472 (2012);

Applications Hexadecanoic-9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d17 Acid (CAS# 81462-28-4) is a useful isotopically labeled research compound.