Deuterated Compounds

Applications Cyclopropyl-d5-amine is labelled Cyclopopylamine (C989140) which can inactivate major human drug-metabolizing cytochromes P450 enzymes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shaffer C., et al.: J. Am. Chem. Soc., 123, 8502 (2001); Polasek, T., et al.: Brit. J. Clin. Pharmaco., 61, 570 (2006)

Applications 1,4-Butane-1,1,2,2,3,3,4,4-d8-diamine (D416027) is a labelled isotope of 1,4-Diaminobutane (D416025). It is an amino acid degradation product. Used in the preparation of hexahydropyrimidines as novel hepatitis C virus inhibitors. Also a reagent in the synthesis of antibacterial castor oil-based polyurethane membranes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hwang, J. et al.: Eur. J. Med. Chem., 70, 315 (2013); Yari, A. et al.: J. Biomed. Mat. Res., 102A, 84 (2014);

Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.
References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);

Applications Labelled 1,2-Bis(2,4,6-tribromophenoxy)ethane (B585425). One of the major "novel" brominated flame retardants (NBFRs) from varous polymer materials. An environmental pollutant.
References Zhu, L., et al.: Environ. Sci. Technol., 40, 3711 (2006), Qui, X., et al.: Environ. Sci. Technol., 42, 31 (2008), Stone, R., et al.: Science, 325, 1055 (2009),

Applications Dibutyldiethyltin is an organotin compound that is an environmental pollutant that is present in sediment and sewage sludge.
References Mueller, M.D. et al.: Anal. Chem., 59, 617 (1987);

Applications Griseofulvin-d3 is the labeled analogue of Griseofulvin (G787500), an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.Environmental contaminants; Food contaminants
References Oxford, et al.: Biochem. J., 33, 240 (1939); Townley, E.R., et al.: Anal. Profiles Drug Subs., 8, 219 (1979)

Applications Suberyl glycine-d4 is deuterium labelled Suberylglycine (S688755), which is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).
References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000); Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009); Scalbert, A., et al.: Metabolomics, 5, 435 (2009)

Applications 1,2-Propanediol-d6 is the d6 labelled analogue of 1,2-Propanediol (P760310) which is used in the preparation of polymers, existing as a linker unit. Also used in the preparation of colchine derivatives as anticancer agents.
References Wayakron Phetphaisit, C. et al.: Int. J. Ad. Adhesion. 41, 127 (2013); Shen, L. et al.: Asian J. Chem., 25, 3294 (2013);

Applications Vardenafil oxopiperazine-D6 is a labelled analogue of Vardenafil oxopiperazine (V098030)

Applications A labelled thioxanthone derivative useful as photoinitiators.
References le Fur, Y., et al.: J. Agric. Food Chem., 47, 2860 (1999), Sanz, M., et al.: Food Chem., 84, 133 (2004), Herent, M., et al.: J. Pharm. Biomed. Anal., 43, 886 (2007),

Stability Light Sensitive
Applications A labelled derivatized of 3-amino-2-oxazolidone (AOZ, A618570), a metabolite of Furazolidone and Nitrofuran.Environmental contaminants; Food contaminants; Heat processing contaminants
References Vroomen, L., et al.: Drug Metab. Rev., 22, 663 (1990), Hoogenboom, L., et al.: Food Chem. Toxicol., 29, 185 (1991), McCracken, R., et al.: Food Addit. Contam., 17, 75 (2000),

Applications A labelled metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.
References Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);

Applications Theobromine-d3 (7-methyl-d3) is deuterium labelled theobromine, which is a metabolite of caffeine.
References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991); Burkart, V., et al.: Nat. Med., 5, 314 (1999); Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003); Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247 (2004)

Applications Betaine-d3 Hydrochloride is a useful gastric acidifier.
References Wilcken, D.E., et al.: N. Engl. J. Med., 309, 448 (1983),

Applications 1-Naphthalenemethanol-d7 (cas# 1189876-86-5) is a compound useful in organic synthesis.

Applications 3-Hydroxypropionic Acid-13C3 Sodium Salt is isotope labelled analogue of 3-Hydroxypropionic Acid Sodium Salt (H952480), which is beta hydroxy acid derived from plants and crops such as corn. 3-Hydroxypropionic Acid is used in the preparation of acrylates and biodegradable polymer polyester.
References Wang, Y. et al.: Biomacromol., 3, 828 (2002); Jiang, X. et al.: Appl. Microbiol. Biotech., 82, 995 (2009);

Stability Volatile
Applications Labelled Formic Acid is used to improve NMR profiling of amino metabolites in biofluids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ye, T. et al.: Anal. Chem., 82, 2303 (2010); Gowda, G.A., Anal. Chem., 82, 8983 (2010);

Applications 1-Pyren-2,3,4,5,6,7,8,9,10-d9-amine is derived from Pyrene-d10 (P849002), which is labelled Pyrene. Occurs in coal tar. Also obtained by the destructive hydrogenation of hard coal.
References Winterstein, et al.: Z. Physiol. Chem., 230, 162 (1934)

Stability Hygroscopic
Applications rac-Propranolol-d7, is the labeled analogue of Propranolol (P831800), a β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),

Applications 1-Bromonaphthalene-d7 (cas# 37621-57-1) is a compound useful in organic synthesis.

Applications Labelled selective herbicide. Potential symptoms of overexposure are irritation of eyes and skin
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dalgaard-Mikkelsen, S., et al.: Pharmacol. Rev., 14, 225 (1962), Muller, K., et al.: J. Environ. Qual., 31, 309

Applications Morpholine-d8 Hydrochloride is used as a reactant in the synthesis of Moclobemide-d8 (M481002), the labeled analogue of Moclobemide (M481000), a reversible monoamine oxidase inhibitor.
References Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985), Burkard, W.P., et al.: J. Pharmacol. Exp. Ther., 248, 391 (1989)

Stability Volatile
Applications Assignments of far-IR (FIR) laser lines have been found for optically pumped Methanol-13C.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Moraes, J.C.S., et. al.: J. Mol. Spec., 177, 302 (1996)

Applications cis-1,2,3,6-Tetrahydrophthalimide-3,3,4,5,6,6-d6 (CAS# 203578-24-9) is a useful isotopically labeled research compound.

Applications Labelled Bromoacetic Acid. Bromoacetic Acid is a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970);

Applications Acetic Acid-1-13C-2,2,2-d3 is used in the technique for determining the concentration and 13C enrichment of acetate in biological fluids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References David, F., et al.: Anal. Biochem., 218, 143 (1994),

Applications Ethyl 2-Oxo-4-phenylbutyrate-d5 (cas# 1189911-53-2) is a compound useful in organic synthesis.

Stability Volatile
Applications N-Hexane (D14, 98%) (cas# 21666-38-6) is a useful research chemical.

Applications Malathion (Diethyl-d10) is used as one of the substances for the clean-up step in post-harvest pesticide residue analysis.
References Ucles, A., et al.: Talanta, 144, 51 (2015)

Applications Labelled Hydrochlorothiazide (H714560). Hydrochlorothiazide is a carbonic anhydrase inhibitor as a diuretic.
References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961), Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981),

Applications N-Octane-D18 (D, 99%) (cas# 17252-77-6) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Post-emergence sulfonylurea herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gubbiga, N.G., et al.: Weed Technol., 9, 574 (1995), Ukrainczyk, L., et al.: J. Agric. Food Chem., 43, 855 (1995)

Applications n-Hexadecane-d34 is the labeled compound of Hexadecane(H293630). Hexadecane has been used to prepare emulsions in water. It is also used as a substrate for the bacterial production of biosurfactants.
References Rang, M., et al.: J. Colloid Interface Sci., 209, 179 (1999); Hills, B., et al.: Magn. Reson. Imaging, 18, 319 (2000); Noordman, W., et al.: Appl. Environ. Microbiol., 68, 4502 (2002)

Stability Hygroscopic
Applications N-Ethyl Benzamid-3-carboxylate-d5 is the isotope labelled analog of N-Ethyl Benzamid-3-carboxylate. N-Ethyl Benzamid-3-carboxylate is an impurity of Deet (D228500) which is an insect repellent.
References Gilbert, I.H., et al.: J. Econ. Entomol., 48, 741 (1955), Ambrose, A.M., et al.: Toxicol. Appl. Pharmacol., 1, 97 (1959), Blomquist, L., Acta Pharmacol. Toxicol., 41, 235 (1977), Yeung, J.M., et al.: Drug Metab. Dispos., 16, 600 (1988),

Applications rac-erythro Methyl-13C, d3-phenidate Hydrochloride is the labeled analog of rac-erythro Methylphenidate Hydrochloride (M325670), which has been shown to exhibit very little therapeutic effect and contribute mainly to the toxic hypertensive effects of this drug.
References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961); Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981); Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001); Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993); Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993)

Applications Isotope labelled Bumetrizole is an intermediate reactant in the synthesis of UV light absorbers for polyester fibers.

Stability Hygroscopic
Applications Labelled Glyoxylic Acid (G755000). Occurs in unripe fruit and in young green leaves; has also been found in very young sugar beets.
References Lelieveld, J., et al.: Nature, 452, 737 (2008), da Silva, G., et al.: Environ. Sci. Technol., 44, 250 (2010),

Stability Hygroscopic
Applications Decanoyl-L-carnitine-d3 Chloride is the isotope labelled analog of Decanoyl-L-carnitine Chloride (D212580); a metabolite of L-Carnitine (C184110) which is an essential cofactor of fatty acid metabolism. Also required for the transport of fatty acids through the inner mitochondrial membrane.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)

Applications N-Acetyl-d3-5-hydroxytryptamine is deuterium labelled N-Acetyl-5-hydroxytryptamine (A179160), which is a metabolite of Melatonin (M215000).
References Reiter, R.J., et al.: J. Biomed. Sci., 7, 444 (2000), Chen, Z., et al.: Am. J. Physiol, 284, 1618 (2003), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),

Applications Isotope labelled herbicide
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009), Bollman, S., et al.: Weed Technol., 23, 264 (2009), Goudarzi, N., et al.: J. Agric. Food Chem., 57, 7153 (2009),

Applications Isotope labelled N-Nitrosodiphenylamine (N525775), which is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211

Applications Chlorpromazine-d6 Oxalate (N,N-dimethyl-d6) (CAS# 1276197-23-9) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications d4-Succinic Acid is a useful reagent as an internal standard for GC/MS analysis.
References Schummer, C., et al.: Talanta, 77, 1473 (2009);

Applications Spiroxamine-d4, is the labeled analogue of Spiroxamine (S683500), which is a spiroketalamine fungicide for use on cereal crops. Spiroxamine inhibits ergosterol synthesis. Spiroxamine is used as agricultural fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, J., et al.: J. Agric. Food Chem., 53, 1857 (2005), Abrahim, A., et al.: J. Pharm. Biomed. Anal., 51, 131 (2010), Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010),

Applications Pentanoic-5,5,5-d3 Acid acts as a reagent used in the isomerization and fragmentation of pentanoic and methylbutanoic acid cation radicals in gas phase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Audier, H., et al.: Bull. Soc. Chim. Fr., 5, 833 (1985)

Applications Labelled 4-Nitrophenol (N496945). Used in the manufacturing of pharmaceuticals, fungicides, dyes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Labelled analogue of Phosphorylethanolamine (P360900). Phosphorylethanolamine is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Myller, A.T. et al.: Appl. Surf. Sci., 257, 1616 (2010);

Applications 3-Nitrobiphenyl is a nitrated benzene metabolite found in the bone marrow of B6C3F1 mice treated with benzene. 3-Nitrobiphenyl displays toxic effect on Tetrahymena pyriformis, Porphyromonas gingivalis, Selenomonas artemidis, and Streptococcus sobrinus.
References Laszlo, T. & Beteringhe, A.: QSAR Combinatorial Sci., 25, 944 (2006); Mintz, C. et al.: QSAR. Combinatorial Sci., 25, 912 (2006); Chen, K. et al.: Chem. Res. Toxicol., 17, 370 (2004)