Deuterated Compounds

<p>Applications cis-1,2,3,6-Tetrahydrophthalimide-3,3,4,5,6,6-d6 (CAS# 203578-24-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Metconazole is an conazole based fungicide used for the control of black sigatoka disease on banana. Metconazole acts primarily as an inhibitor of ergosterol biosynthesis which interferes with the synthesis of fungal cell membranes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cools, H.J., et al.: Pest. Manage. Sci., 68, 1034 (2012); Nam, M.H., et al.: Res. Plant. Disease., 17, 295 (2011);<br></p>

<p>Applications n-Hexatriacontane-d74 (CAS# 16416-34-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Glycolic Acid (G645600). Constituent of sugar cane juice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 23, 259 (1941),<br></p>

<p>Applications Flutolanil-d7 is a labeled analogue of Flutolanil (F599430), a fungicide that has been used for controlling brown patch on creeping bentgrass fairways.<br>References Daniels, J.P., Latin, R.: Plant Disease, 97, 1620 (2013)<br></p>

<p>Applications A reagent used to synthesize various dyes used in the textile industry. This is the labeled analog.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosenkranz, H.S. et al.: Mutagen., 5, 137 (1990);<br></p>

<p>Applications Labelled Coumarin (C755380). Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hazleton, L., et al.: J. Pharmacol. Exp. Ther., 118, 348 (1956), Lake, B., et al.: Food Chem. Toxicol., 37, 423 (1999), Frerot, E., et al.: Flavour Fragrance J., 17, 218 (2002), Yang, Z., et al.: Food Chem., 114, 289 (2009),<br></p>

<p>Applications Isotope labelled Nitrobenzene (N493000), used mainly in the production of the chemical precursor aniline as well as in azobenzene synthesis (1). Also may be reduced through magnetic iron oxide nanocrystals (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Yadav, G. et al.: Chem. Eng. J. 2013 Aug:221(1) pp500-5112. Cantillo, D. et al.: J. Org. Chem. 2013 May 3;78(9):4530-42.<br></p>

<p>Applications 1,4-Dibromobutane-d8 is used in studies pertaining to sulforaphane, a naturally occuring isothiocyanate present in broccoli that shows anti-carcinogenic activity. It is an analog of 1,4-Dibromobutane, a compund used as a catalyst in the polymerization of 2-oxazolines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kuhnert, N. et al.: J. Label. Compd. Radiopharm., 47, 501 (2004); Kobayashi, S. et al.: Macromol., 25, 3232 (1992);<br></p>

<p>Applications Cyanamide-​15N2 is an intermediate in the synthesis of 5-Azacytidine-15N4 (A796002), which is a labelled Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications Eprinomectin-13CD3 is an isotopic analog of Eprinomectin (E590050), a mixture of semi-synthetic Avermectins.<br>References Jones, T.K., et al.: J. Agric. Food Chem., 42, 1786 (1994), Arena, J.P., et al.: J. Parasitol., 81, 286 (1995),<br></p>

<p>Applications Isotope labelled Sodium β-Hydroxyethoxyacetate is used in the synthesis of polymer microspheres that are magnetized and are used for enzyme catalysis or bioaffinity separations.<br>References Horak, D. et al.: Macromol. Biosci., 12, 647 (2012); Pestov, A. et al.: Russ. J. Coord. Chem., 38, 738 (2012);<br></p>

<p>Applications D-Cellobiose-13C12 is the isotope labelled analogue of D-Cellobiose (C255000), a disaccharide consisting of two glucose in a beta 1-4 linkage.<br>References Yang, S.Q.. et al.: Carbo. Poly., 92, 784 (2013);<br></p>

<p>Applications Isotope labelled analogue of Isobutyric Acid, a carboxylic acid found in vanilla. Isobutryic Acid was used as an intermediate in the synthesis of novel inhibitors of signal transducer and activators of transcription 3 signaling pathway.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, M.M., et al.: Euro. J. Med. Chem., 62, 301 (2013);<br></p>

<p>Stability Volatile<br>Applications Glyme (1,2-Dimethoxyethane) (D10, 99%) (cas# 107975-86-0) is a useful research chemical.<br></p>

<p>Applications Dibenzylamine-d10 is the isotope labelled analog of Dibenzylamine (D417505); a chemical contaminant in L-(+)-β-hydroxybutyrate that exhibits direct anticonvulsant actions in vivo.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rho, J.M., et al.: Epilepsia, 43, 358 (2002)<br></p>

<p>Applications A labelled ethylene oxide-DNA adduct. Ethylene oxide (EtO) is classified as a known human carcinogen. The formation of EtO-DNA adducts is considered as an important early event in the EtO carcinogenic process.<br>References Walker, V., et al.: Cancer Res., 52, 4320 (1992), Wu, K., et al.: Chem. Res. Toxicol., 12, 722 (1999), van Sittert, N., et al.: Mutat. Res., 447, 27 (2000),<br></p>

<p>Applications Isotope Labelled 2,4,6-Trichloroanisole (T774085), which is considered the main compound responsible for the cork taint, a wine flavor defect usually perceived as a moldy off-flavor. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Chatonnet P. et al.: J Agric Food Chem. 2004 Mar 10;52(5):1255-62. 2. Cserjesi, A. et al.: Can J Microbiol. 1972 Jan;18(1):45-9.<br></p>

<p>Applications Isotope labelled Ammelide (A633650), which is a metabolite of Melamine (1) (M208700), which acts as a non-protein nitrogen food additive (2). Also present in pet foods as well (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mast R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10. 2. Ehling S. et al.: Food Addit. Contam. 2007 Dec;24(12):1319-25.3. Vail T. et al.: J Anal Toxicol. 2007 Jul-Aug;31(6):304-12.<br></p>

<p>Applications Suberic Acid-d4, is a labeled analogue of Suberic Acid (S688670), which is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.<br>References Cui, C. et al.: Biomat., 34, 3858 (2013); Kusukawa, T. et al.: Tetra., 68, 9973 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications d4-Succinic Acid is a useful reagent as an internal standard for GC/MS analysis.<br>References Schummer, C., et al.: Talanta, 77, 1473 (2009);<br></p>

<p>Applications 3-Hydroxypropionic Acid-D4 Sodium Salt is a deuterium labelled analogue of 3-Hydroxypropionic Acid Sodium Salt (H952480), which is beta hydroxy acid derived from plants and crops such as corn. 3-Hydroxypropionic Acid is used in the preparation of acrylates and biodegradable polymer polyester.<br>References Wang, Y. et al.: Biomacromol., 3, 828 (2002); Jiang, X. et al.: Appl. Microbiol. Biotech., 82, 995 (2009);<br></p>

<p>Applications 2,6-Dimethylphenol-13C8 is an isotope labelled analog of 2,6-Dimethylphenol-13C8. Similar to other xylenol compounds, 2,6-dimethylphenol is used in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. In addition, this compound is used as a a reactant in the synthesis of polyphenylene ether polymers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Carrillo, A. et al.: ANTEC. Soc. Plas. Eng., 69, 945 (2011); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); Guillen, M. et al.: J. Agri. Chem., 46, 1276 (1999);<br></p>

<p>Applications 1,10-Decanedioic-d16 Acid (CAS# 73351-71-0) is a useful isotopically labelled compound for studying saturated fatty acids.<br>References Yamada, T., et al.: Adv. Synth. Catal., 358, 3277 (2016)<br></p>

<p>Applications 2,6-Dimethylphenol-d9 (Major) (cas# 1021325-40-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Tris(2-ethylhexyl) Phosphate-d51 is labelled Tris(2-ethylhexyl) Phosphate (T884650) which is used as a phosphorous flame retardant. Tris(2-ethylhexyl) Phosphate (T884650) is also used as a plasticizer in the preparation of a new potentiometric membrane sensor.<br>References Ballesteros-Gomez, A. et al.: Anal. Chem., 85, 9572 {2013); Gholivand, M. et al.: Adv. Sci. Eng. Med., 5, 73 (2013);<br></p>

<p>Applications Benzoic Acid (Carboxyl-13c, 99%) (cas# 3880-99-7) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Lauramine Oxide-d6 is the isotope labelled analog of Lauramine Oxide. Lauramine Oxide, is an frequently-used amine oxide surfactant. It is strongly hydrophilic , and it forms normal micelles and normal liquid crystalline phases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kocherbitov, v., et al.: J. Molec. Struct.: Theochem., 808, 111 (2007); Kocherbitov, v., et al.: J. Phys. Chem. B., 110 (27), 13649 (2006);<br></p>

<p>Applications Fumaric Acid-d2 is the isotope labelled analog of Fumaric Acid. Fumaric acid is a compound that occurs in many plants. It is essential to vegetable and tissue respiration and also used as an antioxidant. Fumaric acid is also a metabolite of Dimethyl Fumarate (D464965), a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.<br>References Jelitto, T., et al.: Planta, 188, 238 (1992); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Son, H., et al.: J. Agric. Food Chem., 56, 8007 (2008);<br></p>

<p>Applications 4-Aminophenol-15N is an intermediate in the synthesis of Acetaminophen-13C2,15N (A161228), a labelled analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis.<br></p>

<p>Applications Labelled Methylparaben (M325660). It is used as preservative in foods, beverages and cosmetics.<br>References Goodwin, M., et al.: Science, 203, 559 (1979),<br></p>

<p>Applications Isotope labelled Squalane is used as an emollient and moisturizer in cosmetic applications.<br>References Allison, A.: Method, 19, 87 (1999)<br></p>

<p>Applications tert-Butyl Alcohol-d10 is an isotopic analog of Tert-butyl Alcohol (T117540), an organic solvent. It is also used in the synthesis of proteosome inhibitors that are quite potent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kawamura, S. et al.: J. Med. Chem., 56, 3689 (2013); Galy, N. et al.: Tetrahedron Lett., 54, 2703 (2013)<br></p>

<p>Applications Isotope labelled Oxacillin Sodium Salt is a semi-synthetic antibiotic related to Penicillin. Antibacterial.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications Metabolite of oleic and linoleic acids.<br>References Jin, S.J., et al.: Biochem., 29, 8540 (1990).<br></p>

<p>Applications Wittig Reagent<br></p>

<p>Stability Hygroscopic<br>Applications N-Acetylneuraminic Acid-13C,d3 is a labelled Neuraminic Acid derivative.<br>References Oetke, C., et al.: J. Biol. Chem., 277, 6688 (2002)<br></p>

<p>Applications Isotope labelled 9-Bromophenanthrene (B687200), a halogenated polycyclic aromatic hydrocarbon that has been seen to have a room temperature phosphorescence that can be induced by β-cyclodextrin (β-CD) in the presence of cyclohexane; however, trace Fe(III) causes a decrease of the RTP emission.<br></p>

<p>Applications Isotope labelled 1,3-Dibromopropane is a substrate specificity of haloalkane dehalogenases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koudelakova, T., et al.: Biochem. J., 435, 345 (2011),<br></p>

<p>Applications Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, J., et al.: Exp. Neurol., 158, 328 (1999); Brown, M., et al.: Cell, 100, 391 (2000); Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006); Brody, D., et al.: Science, 321, 1221 (2008); More, S., et al.: J. Med. Chem., 52, 4650 (2009);<br></p>

<p>Applications Octadecylamine-d37 is the isotope labelled analog of Octadecylamine. Octadecylamine is used in biological studies for the formation of ion pairing as alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles.<br>References Castro, G.A., et al.: Int. J. Pharma., 381, 77 (2009);<br></p>

<p>Applications Cyclopentanone-2,2,5,5-d4 (CAS# 3997-89-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Compound forms a complex with Mefenamic acid increasing its transdermal permeation properties<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fang, L., et al.: J. Pharm. Sci., 93, 144 (2004), Gibellini, F., et al.: Biochem. J., 415, 135 (2008),<br></p>

<p>Applications Carbamazepine-D10 is used to study occurrence of emerging trace organic chemicals in wastewater effluents in Saudi Arabia.<br>References Alidina, M., et al.: Sci. Total Environ., 478, 152 (2014);<br></p>

<p>Applications Pinoxaden-d3 is a deuterized labeled form of Pinoxaden (P469505), which is derived from Diethylene Glycol Dimethanesulfonate (D444275), an intermediate in the production of alkylating agents.<br>References Wong, I., et al.: J. Med. Chem., 52, 5311 (2009); Muehlebach, M., et al.: Bioorg. Med. Chem., 17, 4241 (2009)<br></p>

<p>Applications Labelled Tolazamide, an antidiabetic.<br>References Welling, et al.: J. Pharmac. Sci., 71, 1259 (1982);<br></p>

<p>Applications Labelled Monobutyl Phosphate (M525050). Mono and dibasic phosphate esters are anionic surfactants which have the main feature of the stability in alkaline conditions over other surfactants. They have a wide range of properties including outstanding wetting, emulsification, lubrication, coupling activity and detergency.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ramirez, F., et al.: Tetrahedron, 35, 1581 (1979);<br></p>

<p>Applications Labelled Benzotriazole. BT is an anticorrosive agent well known for its use in aircraft deicing and antifreeze fluids but also used in dishwasher detergents. Benzotriazole is antiestrogenic in vitro but not in vivo.Isotopic purity: 97% d4, 3% d3.<br>References Rollinson, G., et al.: Biotechnol. Lett., 8, 303 (1986), Cancilla, D., et al.: Environ. Toxicol. Chem., 16, 430 (1997), Beresford, N., et al.: Toxicol. Appl. Pharmacol., 162, 22 (2000), Cornell, J., et al.: Environ. Toxicol. Chem., 19, 1465 (2000), Giger, W., et al.: Environ. Sci. Technol., 40, 7186 (2006),<br></p>

<p>Applications Labelled 1,2-Bis(2,4,6-tribromophenoxy)ethane (B585425). One of the major "novel" brominated flame retardants (NBFRs) from varous polymer materials. An environmental pollutant.<br>References Zhu, L., et al.: Environ. Sci. Technol., 40, 3711 (2006), Qui, X., et al.: Environ. Sci. Technol., 42, 31 (2008), Stone, R., et al.: Science, 325, 1055 (2009),<br></p>