Deuterated Compounds

<p>Applications N,N-Dimethylformamide-d7 is the isotope labelled analog of N,N-Dimethylformamide. N,N-Dimethylformamide-d7 is used as a cofactor for enzymic oxidation of brassinin, which allows the transformation of dithiocarbamate group into an aldehyde equivalent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pedras, M., et al.: Bioorg. Med. Chem., 19, 1390 (2011);<br></p>

<p>Applications n-Hexatriacontane-d74 (CAS# 16416-34-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Undecyl-1,1,2,2-d4 Alcohol (CAS# 1219803-47-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Hydroxyphenylacetic-d6 acid is deuterium labelled 4-hydroxyphenylacetic acid (H949060), which is a compound found in olive oil.<br>References Shu, Y., et al.: Guangdong Huagong, 37, 108 (2010); Papadopoulos, G., et al.: J Am Oil Chem Soc, 68, 669 (1991),<br></p>

<p>Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References IARC Monographs, 4, 97 (1974),<br></p>

<p>Applications Adipic Acid-D8 is a labelled analogue of Adipic acid (A291590), a chemical used in the synthesis of nylon.<br>References Kim, Y. et al.: Ind. Eng. Chem. Res., 51, 15801 (2012)<br></p>

<p>Applications Octanoic Acid-13C4 is an isotopic analog of Octanoic Acid (O237880), which is found naturally in the milk of various mammals. Its esters can be used in perfumery and also in the manufacture of dyes. It is also an antimicrobial pesticide used as a food contact surface sanitizer. Caprylic acid is also used in the treatment of some bacterial infections.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lide, D. R., et al.: CRC Handbook chem. Phys., 70th Ed. (1990); Beare-Rogers, J., et al.: Pue Appl. Chem., 73 (4), 685 (2001);<br></p>

<p>Applications Ethyl-d5 Butyrate is the labeled analogue of Ethyl Butyrate (E900690), which is used in the preparation of novel 2-cyanopyrimidines as cathespin K inhibitors. Also used in the synthesis of pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References By Rankovic, Z. et al.: Bioorg. Med. Chem. Lett.,, 20, 1524 (2010); Takeshita, H. et al.: Bioorg. Med. Chem. Lett., 20, 3893 (2010)<br></p>

<p>Applications Isotope labelled benzene, an organic compound that is a natural constituent of crude oil and one of the most basic petrochemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feng, Z.X.. et al.: J. Phys. Chem. Lett. 4, 285 (2013); Pilling. M., et al.: Chem. Eng. Prog., 108, 32 (2012);<br></p>

<p>Applications A labelled isomer of dichloropropanol; shows metabolite toxicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Omura, M., et al.: Bull. Environ. Contam. Toxicol., 55, 1 (1995),<br></p>

<p>Applications 6-Nitrodopamine-d4 is the labeled analogue of 6-Nitrodopamine(N493722), a reagent used in the detection of cancer biomarker prostate specific antigen (PSA).<br>References Li, H., et. al.: Biosensors Bioelectronics, 26, 3044 (2011)<br></p>

<p>Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);<br></p>

<p>Applications N-(2-Hydroxyethyl)nitotinamide-d4 is labelled N-(2-Hydroxyethyl)nitotinamide (H942365), an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.<br>References Boschi, D., et al.: Bioorg. Med. Chem., 8, 1727 (2000); Nagai, H., et al.: Chem. Pharm. Bull., 32, 1063 (1984); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Cyromazine (C989300). Insect growth regulator. Insecticide.<br>References Hall, R.D., et al.: J. Econ. Entomol., 73, 564 (1980), Hart, R.J., et al.: Aust. Vet. J., 59, 104 (1982),<br></p>

<p>Applications cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester-d5 is an isotopic analog of cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester. cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester is an ethyl analog of cis-7,10,13,16-Docosatetraenoic Acid (D494510). cis-7,10,13,16-Docosatetraenoic Acid has been identified as a protein kinase inhibitor, affecting serotonin levels in studies.<br>References Mirnikjoo, B. et al.: J. Biol. Chem., 276, 10888 (2001);<br></p>

<p>Applications Bis(4-hydroxyphenyl) Sulfone-d4 is the isotope labelled compound commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);<br></p>

<p>Stability Very Hygroscopic<br>Applications 4-Chlorobenzenesulfonic Acid-d4 Sodium Salt is a compound useful in organic synthesis.<br></p>

<p>Applications A labelled derivative of Dibarbituric acid.<br>References Hitchings, G.H., et al.: J. Biol. Chem., 177, 357 (1949),<br></p>

<p>Applications Aclonifen-d5, is the labeled analogue of Aclonifen, which is used as a pesticide and herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laini, A., et al.: Sci. Total Environ., 438, 312 (2012); Fantke, P., et al.: Enviorn. Int., 49, 9 (2012);<br></p>

<p>Stability Volatile<br>Applications 2,5-Dimethylfuran-d6, is the labelled 2,5-Dimethylfuran (D473050). It is an ideal marker for detecting cigarette smoke.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spitzer, W., et al.: Clin. Invest. Med., 13, 17 (1990), Alonso, M., et al.: Anal. Bioanal. Chem., 396, 2989 (2010),<br></p>

<p>Applications DL-Indole-3-lactic Acid Methyl Ester-D5 is an intermediate used in the synthesis of DL-Indole-3-lactic Acid-d5 (I627102), which is the isotope labelled analog of DL-Indole-3-lactic Acid (I627100); a reagent in the synthesis of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one which has weak antibacterial activity against 16 bacterial strains, including Escherichia coli, Bacillus subtilis and Staphylococcus aureus. DL-Indole-3-lactic Acid is also used in the preparation of Monatin, a natural sweet peptidomimetic.<br>References Nguyen, S.T., et al.: Bioorg. Med. Chem. Lett., 20, 5739 (2010); Nakamura, K., et al.: Peptide Sci., 40, 61 (2003)<br></p>

<p>Applications 4-Nitrophenol-13C6 is an intermediate in the synthesis of labelled 4-Aminophenol (A618920). It is also a nephrotoxic metabolite of Acetaminophen (A161220) and Phenacetin (P294580) (1,2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Watanabe, et al.: Drug Metab. Dispos., 38, 1532 (2010)(2) Batuta, S. and Begum, N. A. Synth. Commun. 47, 137-147 (2017)<br></p>

<p>Applications 1,4-Dichlorobutane-d8 (CAS# 83547-96-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Butan-3,3,4,4,4-d5-ol was used to prepare and oxidize 3,3-disubstituted cyclobutenes.<br>References Curry, M., et al.: J. Chem. Soc., 10, 1391 (1980)<br></p>

<p>Applications A labelled metabolite of Mazindol. An imidazolinylphenyl ketone derivatives as antidepressants and diuretics.<br>References Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Murray, S., et al.: Xenobiotica, 31, 135 (2001), Lewis, D., et al.: Drug Metab. Rev., 34, 55 (2002), de Graaf, C., et al.: J. Med. Chem., 48, 2725 (2005),<br></p>

<p>Stability Very Hygroscopic<br>Applications Metolachlor ESA-d6 Sodium Salt is deuterium labelled salt form of Metolachlor ESA (M338860) which is a synthetic herbicide.<br>References Mai, H., et al.: Aquat. Toxicol. 147, 48 (2014); McCarty, G. W., et al.: Sci Total Environ 473-474, 473 (2014);<br></p>

<p>Applications n-Docosane-d46 (CAS# 260411-88-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Butane-1,1,2,2,3,3,4,4-d8-diamine (D416027) is a labelled isotope of 1,4-Diaminobutane (D416025). It is an amino acid degradation product. Used in the preparation of hexahydropyrimidines as novel hepatitis C virus inhibitors. Also a reagent in the synthesis of antibacterial castor oil-based polyurethane membranes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hwang, J. et al.: Eur. J. Med. Chem., 70, 315 (2013); Yari, A. et al.: J. Biomed. Mat. Res., 102A, 84 (2014);<br></p>

<p>Applications A labelled metabolite of Amodiaquine (A634200), an antimalarial.<br>References Bayliss, M., et al.: Xenobiotica, 29, 253 (1999), Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003), Bray, P., et al.: Mol. Microbiol., 56, 323 (2005), Xiang, H., et al.: J. Pharm. Sci., 95, 2657 (2006),<br></p>

<p>Applications Used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948),<br></p>

<p>Applications 4-Hydroxybenzhydrazide-d4 Major is labelled 4-Hydroxybenzhydrazide which works as an indicator in the determination of carbohydrates. Tissue (liver) bounded 4-Hydroxybenzhydrazide, the acid-hydrolyzable side chain of Nifuroxazide (N458500) can be used as a marker to monitor it’s use as an antibiotic in chicken.<br>References Lever, M., et al.: Anal. Biochem., 139, 205 (1984); Rocco, M., et al.: Anal. Biochem., 377, 251 (2008); Gao, F., et al.: J. Sci. Food Agr., 93, 2172 (2013)<br></p>

<p>Applications A deuterated alcohol used in the study of lignite liquefaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kuznetov, P.N. et al.: Fuel, 70, 559 (1991);<br></p>

<p>Applications Triclabendazole Sulfone-D3 is a stable isotopically labelled metabolite of Triclabendazole (T774175), an anthelmintic.<br>References Wolff, K., et al.: Vet. Parasitol., 13, 145 (1983)<br></p>

<p>Applications Isotope labelled 2-Toluidine (T536205) is a carcinogenic and toxic aromatic amine and is a potential bladder cancer risk, surmised from urine assessment and analysis (1). It is contained in hair dye, henna and dyed hair samples (2,3). Possible mutagen (4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. El-Bayoumy, K. et al.: Cancer Res. 1986 Dec;46(12 Pt 1):6064-7.2. Turesky R. et al.: Chem. Res. Toxicol. 2003 Sep;16(9):1162-73.3. Andrew, A. et al.: Int. J. Cancer. 2004 Apr 20;109(4):581-6.4. Kirkland, D. et al.: Mutat. Res. 2005 Dec 30;588(2):88-105.<br></p>

<p>25-Hydroxyvitamin D3 monohydrate is a vitamin D analog that has been shown to reduce elevated levels of parathyroid hormone and improve bone mineral density. It is used for the treatment of chronic kidney disease, hyperparathyroidism, and osteoporosis. 25-Hydroxyvitamin D3 monohydrate has been found to be effective in the treatment of these conditions because it increases the body's production of calcitriol, the active form of vitamin D. Calcitriol promotes calcium absorption in the gut and reduces renal excretion of calcium by inhibiting parathyroid hormone synthesis. This drug also inhibits pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.</p>

<p>Diethylstilbestrol-d8 is a synthetic estrogen that is used as an analytical standard for the detection of 17β-estradiol and estrone. Diethylstilbestrol-d8 has been used to monitor the synthesis of estrogens in human tissues and to measure the effects of estrogen on target cells. It has been shown that this compound binds to the estrogen receptor, which mediates its effects in a similar manner as natural estrogens. Diethylstilbestrol-d8 is also used to determine if the estrogen receptors are present in a sample. This can be done by measuring the response of cells to diethylstilbestrol-d8 or by measuring its binding to any receptor sites in a sample. Diethylstilbestrol-d8 has also been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>Albendazole-sulphone-D3 is an analyte that is extracted from a dispersive sulphoxide. It is extracted by an acetonitrile phase extraction and analyzed by liquid chromatography. Albendazole-sulphone-D3 has been shown to have anthelmintic properties, which are due to its ability to inhibit the synthesis of folic acid in nematodes. This drug binds to the acetylcholine receptor site on the worm's neuromuscular junction, preventing acetylcholine from accessing this site and causing paralysis. It has also been shown to be effective against roundworms (Ascaris lumbricoides), hookworms (Ancylostoma duodenale), and whipworms (Trichuris trichiura).</p>

<p>YD2-o-C8 is a low light, metal-coordinating organic molecule that has been shown to enhance the performance of perovskite solar cells. It is a multi-walled carbon nanotube with a metal atom at each end. The interactions between the YD2-o-C8 and the perovskite are believed to be due to an electron transfer process that takes place within the perovskite's molecular orbitals. This interaction leads to increased efficiencies in these devices.</p>

<p>DL-Pipecolic acid-d9 is a form of pipecolic acid that is used to prepare samples for analysis. It is analysed in the form of a nonresponsive interaction with bioanalysis, which is then profiled to provide population data. This compound has been validated for neonates and infants. The flow rate for DL-pipecolic acid-d9 is 3 mL/min.</p>

<p>Sex pheromone inhibitor IPD1 is an antibody that inhibits the production of sex pheromones by Streptococcus faecalis. It is used to diagnose and treat allergic diseases, such as atopic dermatitis or bronchial asthma. This antibody binds to a protein called polypide, which is involved in the synthesis of sex pheromones, and inhibits its activity. It has been shown to inhibit the production of sex pheromones by Streptococcus faecalis when analyzed using an SDS-polyacrylamide gel electrophoresis method. Sex pheromone inhibitor IPD1 also binds to antibodies against streptococcus, acari, and other bacteria.</p>

<p>Please enquire for more information about 4-Bromofluorobenzene-D4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Amodiaquine-d10 is a quinoline derivative that is used in the treatment of malaria. It has been shown to have a good bioavailability and is not metabolized by the body. Amodiaquine-d10 has a low risk of toxicity, which makes it appropriate for use in patients with an uncomplicated malaria infection. The plasma concentrations are determined through an analysis of the presence of amodiaquine-d10 in plasma samples. The pharmacokinetic study was performed using an ionization interface and a spectrometer. The evaporation technique was used to measure the concentration of amodiaquine-d10 in plasma samples, which were then analyzed using high performance liquid chromatography (HPLC). This technique allows for the measurement of amodiaquine-d10 at low concentrations and can differentiate between drugs that are chemically similar.</p>

<p>Vitamin D2 is a fat-soluble vitamin that is required for the absorption of calcium and phosphate. It can be obtained through dietary supplements or by exposure to sunlight. Vitamin D2 is a prohormone that needs to undergo two hydroxylation reactions in the liver and kidney before it becomes the active form, calcitriol. Vitamin D2 has been shown to have beneficial effects on bone mineralization and phosphatase activity, as well as an inhibitory effect on the production of parathyroid hormone. Hydroxyapatite, a component of bone tissue, has been shown to react with vitamin D2 in vitro, which may be due to its ability to act as an additive or stabilizer.END&gt;&gt;</p>

<p>Glycine is an amino acid that is found in the human blood. It is a non-essential amino acid and has a high level of stability. Glycine can be used as an untreated control to measure the stability of other compounds; it has been shown to be stable for up to six months at room temperature and for more than one year when frozen. Glycine is not found in any food sources, but can be synthesized by the body from other amino acids. The following are sample product descriptions: Rifapentine Rifapentine is an anti-tuberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis. Rifapentine inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human</p>

<p>5-(Hydroxymethyl)-2’-deoxycytidine is an activator that can be used in the synthesis of nucleosides and phosphoramidites. It is a novel compound that has antiviral, anticancer, and ribonucleoside activities. 5-(Hydroxymethyl)-2’-deoxycytidine is a monophosphate derivative that can be used to synthesize diphosphates, which are important for DNA replication. The drug has been shown to have anticancer properties against breast cancer cells. It also inhibits the growth of leukemia cells by preventing the synthesis of DNA and RNA.</p>

<p>L-Proline-13C5 is a high quality, reagent grade, complex compound that is useful as an intermediate for the synthesis of fine chemicals. It has CAS No. 201740-83-2 and can be used in a variety of chemical reactions to produce useful scaffolds or building blocks. L-Proline-13C5 is also a versatile building block that can be used in research or pharmaceutical applications. It is a speciality chemical that has many uses including reaction components for the synthesis of other compounds.</p>

<p>Tolterodine-D14 is a postoperative drug that belongs to the class of non-selective muscarinic receptor antagonists. It has been evaluated for pharmacokinetic properties in plasma samples from patients undergoing surgery. Tolterodine-D14 undergoes extensive hepatic metabolism, with only about 50% of the drug being excreted unchanged in urine. The elimination half-life of this drug ranges from 2 to 3 hours. Tolterodine-D14 has been shown to be bioequivalent to the reference drug (tolterodine) and can be used as a control level for chromatographic analyses.</p>

<p>Leucocrystal violet-d6 is a dye that has been used for decades as a fluorescent marker for chromatographic analysis. It is commonly used as an indicator to determine the purity of acetonitrile in analytical methods. Leucocrystal violet-d6 is prepared by dissolving the dye in acetonitrile and adding it to a test sample. The solvent is then evaporated and the dye will be left behind. Leucocrystal violet-d6 has a strong absorption band at approximately 605 nm, which can be detected using a spectrometer. The major limitation of this method is that it cannot be used to analyze samples containing water or organic solvents such as methanol or ethanol.</p>