Deuterated Compounds

<p>Applications Vilazodone N-Oxide-d4 is the isotope labelled analog of Vilazodone N-Oxide (V265020); a metabolite of Vilazodone (V265000) which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Also an antidepressant.<br>References Bartoszyk, G., et al.: Eur. J. Pharmacol., 322, 147 (1997); Heinrich, T., et al.: J. Med. Chem., 47, 4684 (2004)<br></p>

<p>Applications Benzo[e]pyrene-d12 (CAS# 205440-82-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromohexadecane-16,16,16-d3 (CAS# 284474-40-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethynylbenzene-13C2, is the labeled analogue of Ethynylbenzene (E932150), which is an aromatic hydrocarbon, is important in the petrochemical industry as an intermediate in the production of styrene, which in turn is used for making polystyrene, a common plastic material.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xiang, J., et al.: Tetrahedron Lett, 37, 5269 (1996);<br></p>

<p>Applications Sodium Butyrate-4,4,4-d3 (CAS# 347840-05-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Butyrate-3,3,4,4,4-d5 (CAS# 204244-79-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(3-Methylbutyryl)glycine-2,2-d2 (CAS# 1219795-09-1) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Guaiacol-beta-D-gentiobioside-d3, is the labeled analogue of Guaiacol-beta-D-gentiobioside (G245570), a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications 2-Nitroaniline-4,6-d2 (CAS# 1276197-41-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorotoluene-alpha-d1 (CAS# 131088-90-9) is a useful isotopically labeled research compound. This compound can be used in to detect isotopic effects, and can be detected using NMR spectroscopy.<br>References Langen, H.,et.al., Z. Naturforsch.A., 46,1123-1130,(1991); Holland, H., et.al., J.Chem.Soc. Perkin Trans.1., 36,1107-1165,(2008);<br></p>

<p>Applications Tolcide 2230-d4 is derived from 2-Benzothiazolethiol-d4 (B206652), which is a useful building block in the synthesis of various pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,8-Dimethylnaphthalene-d12 (CAS# 104489-29-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bromocyclopropane-d4 is labelled Bromocyclopropane (B682760) which is used as a reagent to synthesize substituted (carboxycyclopropyl)glycines as potent and selective group II metabotropic glutamate receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ornstein, P., et al.: J. Med. Chem., 41, 358 (1998)<br></p>

<p>Applications Isotope labelled Thymine (T412150), nitrogenous base component in the nucleic acid of DNA.<br>References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008), Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009), Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009), Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009),<br></p>

<p>Applications 6-Amino-5-nitrosouracil-13C,15N2 is an intermediate in the synthesis of Xanthine-13C15N2 (X499952), which is an isotope labelled analog of Xanthine (X499950), a substance that can be found in animal organs, yeast, potatoes, coffee beans, tea. Xanthine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives that exhibits adenoside receptor antagonist properties.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>

<p>Applications Isotope labelled Nitrobenzene (N493000), used mainly in the production of the chemical precursor aniline as well as in azobenzene synthesis (1). Also may be reduced through magnetic iron oxide nanocrystals (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References Cantillo, D. et al.: J. Org. Chem. 2013 May 3;78(9):4530-42.Yadav, G. et al.: Chem. Eng. J. 2013 Aug:221(1) pp500-511<br></p>

<p>Applications Bromobenzene-2,3,5,6-d4 (CAS# 64646-03-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Formamide-d3 is labelled Formamide (F691780 ). Formamide (F691780) is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide (F691780) is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to “flow”<br>References Chomczynski, P.: Nuc. Acids Res., 20, 3791 (1992); Ma, X. &amp; Yu, J.: Acta Polym. Sinica 2, No vol. given, 240 (2004); Rodriguez-Gonzalez, F., et al.: Polymer, 44, 1517 (2003); Shi, Q., et al.: Polym. Degrad. Stabil., 96, 175 (2011)<br></p>

<p>Applications Labelled 2-Chloropyridine (C380605). (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during the decomposition of specific insecticides. 2-CPY was found to be genotoxic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Demsia, G., et al.: Mutat. Res., 634, 32 (2007), Stapleton, D., et al.: Water Res., 43, 3964 (2009),<br></p>

<p>Applications (±)-1-Phenylethanol-d10 (CAS# 219586-41-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(Trifluoromethoxy)benzoic Acid-13C is labeled 4-(Trifluoromethoxy)benzoic Acid (T790720) which is a substituted benzoic acid used in the preparation of a various biologically active compounds such as antifungal and antimalarial agents.<br>References Jiang, Y. et al.: Bioorg. Med. Chem. Lett., 21, 4471 (2011); Herrin, T.R. et al.: J. Med. Chem., 18, 1216 (1975);<br></p>

<p>Applications 2-Hexanone-1,1,1,3,3-d5 (CAS# 4840-82-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Octatriacontane-d78 (CAS# 1219803-25-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Phenyl-d5-ethylamine (CAS# 912627-99-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,6-Dinitrotoluene-alpha,alpha,alpha-d3 (CAS# 93951-90-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled (6R,7S)-Cefoperazone (C242890). (6R,7S)-Cefoperazone is the enantiomer of Cefoperazone (C242900) as an impurity.<br>References Fabre, H., et al.: J. Pharm. Sci., 73, 611 (1984), Strasters, J., et al.: Anal. Chem., 63, 2503 (1991), Chen, Z., et al.: World Notes Antibiot., 25, 249 (2004),<br></p>

<p>Applications Labelled analogue of Diethyl Hexyl Phosphate, an alkylphosphoric acid used in the extraction of uranium from molybednum. Diethyl Hexyl Phosphate is also used as a solid dispersing agent in certain food and beverage containers.<br>References Li, Z.: Youkuangye, 5, 14 (1986);<br></p>

<p>Applications Hexadecanoic-11,11,12,12-d4 Acid (CAS# 75736-57-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,1-Dichloroethane (2,2,2-D3, 98%) (cas# 56912-77-7) is a useful research chemical.<br></p>

<p>Applications DL-4-Hydroxyphenylalanine-3,3-d2 (CAS# 35693-18-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,3,5-Trimethylphenol-d11 (CAS# 362049-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications T-705 Ribofuranose-13C5 is the labeled analog of T-705 Ribofuranose (T003200), a reagent used for the preparation of pyrazine-ribofuranose derivatives as antiviral agents that are useful in the treatment of viral infections.<br>References Zhong, B., et al.: Faming Zhuanli Shenqing, 2014:924257 (2014)<br></p>