Deuterated Compounds

Applications n-Decyl-9,9,10,10,10-d5 Alcohol (CAS# 57368-00-0) is a useful isotopically labeled research compound.

Applications N-​1-​Adamantyl-​d15-acetamide is an intermediate in the synthesis of 1-Adamantan-d15-amine (A575823), which is a labeled NMDA-receptor antagonist. Antiviral; antiparkinsonian.
References Vernier, V.G., et al; Toxicol. Appl. Pharmacol., 15, 642 (1969); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 12, 1 (1983)

Applications Nicotine metabolite.
References Sai, Y. & Gorrod, J.W.: Drug. Metab. Drug. Interact., 12, 93 (1995); Nishida, T. et al.: Org. Magn. Resonance., 13, 434 (1980)

Applications A labelled metabolite of Quetiapine.
References McConville, B., et al.: J. Clin. Psychiatry, 61, 252 (2000), Wong, Y., et al.: J. Clin. Psychopharmacol, 21, 89 (2001), Cooper, K., et al.: Eur. J. Clin. Pharmacol., 59, 51 (2003),

Applications 1-Bromoheptane-1-d1 (CAS# 38007-40-8) is a useful isotopically labeled research compound.

Applications Bis(4-cyanophenyl)methanol-d4 is labelled Bis(4-cyanophenyl)methanol (B422852) which is a metabolite of Letrozole (L330100), a nonsteroidal aromatase inhibitor structurally related to Fadrozole.
References Bhatnagar, A.S., et al: J. Steroid Biochem. Mol. Biol., 37, 1021 (1990), Pfister, C.U., et al.: J. Pharm. Sci., 83, 520 (1994), Lipton, A., et al.: Cancer, 75, 2132 (1995)

Applications 4-(4-Fluorobenzoyl)-3-hydroxymethylbenzonitrile-D4 is a labelled analogue of 4-(4-Fluorobenzoyl)-3-hydroxymethylbenzonitrile (F588365).

Applications Antioxidant and preservative for foods, cosmetics, pharmaceuticals; also rubber and petrolium products.
References Lehman, A.J., et al.: Adv. Foods Res., 3, 197 (1951), Verhagen, H., et al.: Chem. Biol. Interact., 80, 109 (1991), Williams, G.M., et al.: Food Chem. Toxicol., 37, 1027 (1999),

Applications 4-Amino-D2 Benzoic Acid Monosodium Salt is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.
References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),

Applications Glyoxylic Acid Hydrate-13C2 is the labelled hydrated analog of Glyoxylic Acid (G754995) which is used as a reagent in the synthesis of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-L-leucine, a novel nonpeptide chemotype selective for neurotensin receptor 2. Also used as a reagent in the synthesis of elemonic acid derivatives as Pin1 inhibitors. Glyoxylic Acid-13C2 was used in the synthesis of carbon labelled 6-N-carboxymethyllysine (CML) which is the most used marker for advanced glycation endproducts in food analysis.
References Thomas, J.B., et al.: Bioorg. Med. Chem. Lett., 25, 292 (2015); Li, X., et al.: Bioorg. Med. Chem. Lett., 24, 5612 (2014); Delatour, T., et al.: Amino Acids, 30, 25 (2006);

Applications Solifenacin-d7 hydrochloride is deuterium labelled Solifenacin hydrochloride (S676700), which is a Muscarinic M3 receptor antagoinst and used to treat urinary incontinence.
References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002), Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004), Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004), Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005), Habb, F., et al.: Eur. Urol. 47, 376 (2005), Payne, C.K., et al.: Drugs, 66, 175 (2006),

Applications 4-Nitrofluorobenzene-13C6 is an intermediate for the synthesis of Flufenacet-13C6 (F599422), labelled Flufenacet (F599420) which is an anilide based herbicide that is applied to the soil surface or incorporated before the crop is emerged. Flufenacet is often used in field corn, corn grown for silage or soybeans to control annual grasses and broadleaf weeds.
References Hulting, A.G., et al.: Weed. Technol., 26, 230 (2012); Bailly, G.C., et al.: Crop Protect., 34, 96 (2012)

Applications 2,2-Dimethylbutyric-d11 Acid (CAS# 1219804-04-2) is a useful isotopically labeled research compound.

Applications Iodoacetamide-d4 (CAS# 1219802-64-8) is a useful isotopically labeled research compound.

Applications 1-Bromooctane-8,8,8-d3 (CAS# 69373-25-7) is a useful isotopically labeled research compound.

Applications 2-[[[[1-(Methyl-d3)ethyl-1,2,2,2-d4]amino]sulfonyl]amino]-benzoic Acid Methyl Ester is an intermediate in the synthesis of Bentazon-d7 (B120583). Bentazon-d7 is deuterium labelled Bentazon (B120580), which is a herbicide.
References Ghirardello, D., et al.: Environ. Sci. Technol., 44, 9010 (2010); Frihauf, J., et al.: Weed Technol., 24, 262 (2010); Rotroff, D., et al.: Toxicol. Sci., 117, 348 (2010)

Applications tert-Butyl 2-Bromo-2-methylpropanoate-D6 is an intermediate in the synthesis of Aztreonam-d6 (A965202), which is an isotope labeled Azetreonam (A965200), the first totally synthetic monocyclic β-lactam antibiotic.
References Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982), Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988),

Applications Isoproturon-d6 is deuterized or labeled form of Isoproturon (I874500), which is a pre-and post emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.
References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983)

Applications Propargyl Alcohol-13C3 is labelled Propargyl Alcohol (P762550) which is used as a corrosion inhibitor, a metal complex solution, a solvent stabilizer and an electroplating brightener additive. It is also used as an intermediate in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhang, T., et al.: Res. Chem. Interm. (2013); Choudhary, Y., et al.: SPE Product. Operat., 28, 268 (2013); Hed, Y., et al.: J. Mater. Chem. Mater. Bio. Med., 1, 6015 (2013)

Applications L-Methionine-d3-N-FMOC (S-methyl-d3) (CAS# 502692-58-2) is a useful isotopically labeled research compound.

Applications 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester-d5 is labelled 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester (T302660) which is used as a reagent to prepare N-heterocyclylcarbamates and biphenylisoxazoles as lysophosphatidic acid (LPA) receptor antagonists.
References Buckman, B., et al.: PCT Int. Appl., WO 2013025733 A1 20130221 (2013)

Applications α-Methylglyceric Acid-d4 is derived from Acetone-d6 (A163802), which is an isotope labeled Acetone, a common organic building block in organic chemistry. Also, it is the deuterated form of α-Methylglyceric Acid (M311505), which is a biogenic secondary organic aerosol used in air quality diagnosis.
References Neubert, L., et al.: J. Am. Chem. Soc., 134, 12239 (2012); Zhai, J.J., et al.: J. Am. Soc. Mass. Spec., 20, 1366 (2009); Ru, P., et. al.: Environ. Sci. Technol., 48, 8491 (2014); Napelenok, S.L., et. al.: Environ. Sci. Technol., 48, 464 (2014); Stone, E.A., et. al.: Environ. Chem., 9, 263 (2012)

Applications 6-Chloro-N-(2,2-difluoroethyl)-3-pyridinemethanamine-d2 is an intermediate used in the synthesis of Flupyradifurone-d5 (F598616), which is the labeled form of Flupyradifurone (F598615), can be used as an insecticide.
References Anon, IP.com J., 12, 19 (2011)

Applications Heptanoic-2,2,3,3-d4 Acid (CAS# 1219803-28-7) is a useful isotopically labeled research compound.

Applications Reagent used in the addition of labelled cyclopropane.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006),

Applications Diethyl L-(+)-Tartrate-13C4 is the isotope labelled analog of Diethyl L-(+)-Tartrate. Diethyl L-(+)-Tartrate is used as a chiral reagent in a host of chemical reactions, such as the synthesis of isoquinoline alkaloids and arundic acid, which has been used in acute ischemic stroke therapy.
References Ziolkowski, M. et al.: Tetrahedron Lett., 41, 1963 (2000); Fernandes, R. et al.: Tetrahedron Lett. 50, 5903 (2009);

Applications n-Tetratriacontane-d70 (CAS# 1219805-47-6) is a useful isotopically labeled research compound.

Applications Diethylamine-13C4 Hydrochloride is the labelled salt of Diethylamine (D443485).

Applications L-Propoxyphene-d5 Hydrochloride is the isotope labelled analog and L-isomer of Propoxyphene Hydrochloride (P831500); a controlled substance (opiate) and analgesic (narcotic). The α-DL-and D-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive. Oral administration of L-Propoxyphene Hydrochloride enhances the analgesic activity of D-Propoxyphene Hydrochloride.
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971); McEwan, B., et al.: Anal. Profiles Drug Subs., 1, 301 (1972); Murphy, P.J., et al.: J. Pharmacol. Exp. Ther., 199, 415 (1976)