Deuterated Compounds

Applications Hexamidine-d12 Impurity A Hydrochloride is the labeled analogue of Hexamidine Impurity A Hydrochloride is an impurity of Hexamidine (H294205), an amidine compound use in the treatment of amyloid-related diseases; also use as preservative in cosmetics. Antiseptic.
References Taylor, P., et al.: J. Pharmaceut. Sci., 72, 1477 (1983); Granel, F., et al.: Clin. Infect. Diseases, 23, 839 (1996); Bailly, C., et al.: Biochem. J., 323, 23 (1997); Enyedy, I., et al.: J. Med. Chem., 44, 1349 (2001)

Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine-d3 is the isotope analog of Methyl(4-methylnaphthalen-1-ylmethyl)amine. Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.
References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)

Applications 1,5-Dibromopentane-d10 (CAS# 1219802-90-0) is a useful isotopically labeled research compound.

Applications N,N-Dimethyl-d3-glycine HCl (N-methyl-d3) (CAS# 1219795-14-8) is a useful isotopically labeled research compound.

Applications N-Fmoc-(13C9,15N)-L-Tyrosine O-Tertbutyl Ether is the isotope labelled protected form of L-Tyrosine (T899975), an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines (e.g. Norepinephrine HCl [N674500]) in human keratinocytes, and also for the synthesis of proteins and thyroid hormones.
References Gülçin, ?.: Amino Acids, 32, 431 (2007); Langen, K., et al.: Nuc. Med. Biol., 29, 625 (2002); Schallreuter, K., et al.: J. Invest. Derm., 104, 953 (1995); Zhang, W., et al.: Neuropharmacology, 47, 438 (2004)

Applications p-Xylene-alpha,alpha,alpha-d3 (CAS# 26204-18-2) is a useful isotopically labeled research compound.

Applications Labelled (R)-tert-Butyl 2-(tert-Butoxycarbonylamino)-5-oxo-5-phenylpentanoate is used in inhibition studies relating to elucidating the mechanism for carbapenam synthetase. Also used in the synthesis of sphingosine 1-phosphate receptor antagonists in the treatment of multiple sclerosis
References Gerratana, B. et al.: Biochem., 42, 7836 (2003); Ibrahim, M. et al.: J. Med. Chem., 55, 1368 (2012);

Applications 1,3-Propanediol-d8 is the labelled version of 1,3-Propanediol (P760320), which is a common organic reagent used in the synthesis of polymers and used in industrial organic chemistry for the synthesis of lubricants, foods, medicines and cosmetics.
References Sun, Y. et al.: Bioproc. Renew. Res. Commod. Bioprod., 289 (2014)

Applications Diethyl-d10-amine HBr (CAS# 1219803-53-8) is a useful isotopically labeled research compound.

Applications Trilithium UDP-glucuronic Acid-3C1, 5N2 is an isotope labelled analog of Trisodium UDP-glucuronic Acid (T886285). Trisodium UDP-glucuronic Acid is a reactant used in the enzymatic preparation of β-glucuronides.
References Stevenson, D.E., et. al.: Collect Czech. Chem. C., 65, 117 (2000); Robotham, S.A., Brodbelt, J.S.: Biochem. Pharmacol., 82, 1764 (2011); Kren, V., et. al.: Drug Metab. Dispos., 28, 1513 (2000)

Applications Butyl Phenyl Phosphate-d9 is the deuterated form of Butyl Phenyl Phosphate (B809590), which is a phosphorus flame retardant additive.
References Sundkvist, A. M., et al.: Environ. Monit. Assess., 12, 943 (2010),

Applications Impurity in the production of labelled Phenylbutazone (P319572)
References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),

Applications Synaptamide-d4 is labelled Synaptamide (S910000) which is an endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. It has potent synaptogenic activity and structural similarity to anandamide. Synaptamide (S910000) is subjected to hydrolysis by fatty acid amide hydrolase, and can be oxygenated to bioactive metabolites.
References Kim, H., et al.: Prostaglandins Leukot Essent Fatty Acids, 88, 121 (2013); Burstein, S., et al.: Bioorg. Med. Chem., 16, 9644 (2008); Fu, J., et al.: J. Biol. Chem., 282, 1518 (2007)

Applications 1,8-Octanedioic-d12 Acid (CAS# 169397-99-3) is a useful isotopically labeled research compound.

Applications An intermediate for the synthesis of analogs of retinoid lactone.
References Lewin, A.H., et al.: Pharm. Res., 12, 983 (1995).

Applications 2-Nitrotoluene-alpha,alpha,alpha-d3 (CAS# 70786-67-3) is a useful isotopically labeled research compound.

Applications n-Heptyl-5,5,6,6,7,7,7-d7 Alcohol (CAS# 1219804-99-5) is a useful isotopically labeled research compound.

Applications L-Phenyl-d5-alanine-N-FMOC (CAS# 225918-67-2) is a useful isotopically labeled research compound.

Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.

Applications Isotope labelled δ-Valerolactone used in the synthesis of various antibiotics including the ionophore antibiotic X-14547A. Also used in the preparation of polyesters via copolymerization.
References Nicolaou, K. et al.: J. Org. Chem., 50, 1440 (1985); Parrish, B. et al.: J. Polym. Sci. Polym, Chem., 40, 1983 (2002);

Applications Sodium Hexadecanoate-16,16,16-d3 (CAS# 347841-37-6) is a useful isotopically labeled research compound.

Applications Ethylene Glycol Monodecanoate-d4 is a deuterated version of Ethylene Glycol Monodecanoate (E917555), a reactant in the synthesis of water-woluble phospholipid analogues as inhibitors of phospholipase C.
References Franklin, Christopher L., et al.: J. of Org. Chem., 68(19), 7298-7307 (2003)

Applications n-Octyl-1,1-d2 Alcohol (CAS# 78510-02-8) is a useful isotopically labeled research compound.

Applications Ethanethiol-13C2, is the labeled analogue of Ethanethiol (E676470), is used in the evaluation and application of static headspace-multicapillary column-gas chromatography-ion mobility spectrometry for complex sample analysis.
References Denawaka, C., et al.: J. Chromat. A., 1338, 136 (2014)

Applications Ethyl Trifluorocrotonate-3(13C) is the labeled version of Ethyl trans-4,4,4-Trifluorocro (E930455), which is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. It can also be used in the synthesis of novel amino trifluoromethyl cyclopropane carboxylic acid derivatives in the presence of nucleophilic reagents.
References Keita, M. et al.: Tetrahedron, 69, 3308 (2013)