Deuterated Compounds

<p>Applications 4-Hydroxypiperidine-D4 is an isotope labelled form of 4-Hydroxypiperidine (H950845), a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999);<br></p>

<p>Applications Ethyl Cyanoacetate-d2 is the deuterated form of Ethyl Cyanoacetate (E905555), which is a reagent used in the labeled pyrimidine and purine synthesis;Also, it is an intermediate used in the synthesis of N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine-d4 (C424342), which is an isotope labeled N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine is a metabolite of Tianeptine (T436800), a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009); Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991), Nair, M. et al.: Analyst, 123, 2267 (1998)<br></p>

<p>Applications Ethylene Glycol Monostearate-d4 is a deuterated version of Ethylene Glycol Monostearate (E917480), a polymer chain used in the synthesis of PEG chains which may act as vesicles in the transport of drugs.<br>References Takeoka, S. et al.: J. Am. Chem. SOc., 122, 7927 (2000)<br></p>

<p>Applications Labelled 2-Chloro-N,N-diethylethylamine Hydrochloride, used in the preparation of nonsteroidal antiestrogens. As well, it is used in the synthesis of novel cyanopyridine derivatives used in the design of antibacterial drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jones, C. et al.: J. Med. Chem., 27, 1057 (1984); Bogdanowicz, A. et al.: J. Hetero. Chem., 50, 544 (2013);<br></p>

<p>Applications Methyliminodiacetic-d4 Acid (CAS# 1219803-27-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclohexane-d11 (CAS# 1520-59-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-Xylene-d4 (ring-d4) (CAS# 16034-43-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Di(methyl-d3)-naphthalene is the labeled analogue of 1,3-Dimethylnaphthalene (D476385), a polycyclic aromatic hydrocarbon (PAH) that has been shown to have cytochrome P 450 2A6 and 2A5 inhibitory activities.<br>References Wammer, K.H., Peters, C.A.: Environ. Sci. Technol., 39, 2571 (2005); Roy, K., Roy, P.P.: Eur. J. Med. Chem., 44, 1941 (2009)<br></p>

<p>Applications Benzo[b]thien-2-yl ketone-D10 is a labelled analogue of Benzo[b]thien-2-yl ketone (B207710). Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. &amp; Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>

<p>Applications 3-Aminodihydro-​d2-2(3H)​-​thiophenone-​4,​5-​d2 is an intermediate in the synthesis of Erdosteine-d4 (E596052), which is the isotope labelled analog of Erdosteine (E596050); a mucolytic developed for the treatment of chronic obstructive bronchitis.<br>References Kuvandik, G., et al.: Toxicol. Pathol., 36, 714 (2008); Koyu, A., et al.: Mol. Cell. Biochem., 331, 43 (2009); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010)<br></p>

<p>Applications 2-Furamide-3,4,5-d3 (CAS# 1219799-31-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenyl 4-Bromo-2-(ethyl-d3)pyridine-1(2H)-carboxylate is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications (±)-2-Ethylhexanoic-d15 Acid (CAS# 352431-38-0) is a useful isotopically labeled research compound.<br></p>