Deuterated Compounds

<p>Applications N-(Benzoyl)piperazine-2,2,3,3,5,5,6,6-d8 (CAS# 1219805-49-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Isopropyl DL-Mandelate is used in nonporous silica/alumina amorphous material. Pregabalin (P704800) impurity.<br>References Wang, Z. et al.:; ACS Catal., 3, 1573 (2013);<br></p>

<p>Applications 4,4-Bis(4-aminophenylsulfonyl)-azobenzene-d16 is the isotope labelled analog of 4,4-Bis(4-aminophenylsulfonyl)-azobenzene. 4,4-Bis(4-aminophenylsulfonyl)-azobenzene is synthesized from dapsone (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>

<p>Applications N-(Phenyl)-2-naphthylamine is a reagent in the preparation of unsymmetrical triaryldiamines as thermally stable hole transport layers for various organic LEDs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koene, B. et al.: Chem. Mat., 10, 2235 (1998);<br></p>

<p>Applications Isotope labelled D-Glucitol is a sugar alcohol obtained from the reduction of glucose and is naturally found in various fruits such as apples, pears and peaches. D-Glucitol has been widely used as a sweetener, laxative, various medical applications and in cosmetic products.<br>References Wang, Z.J., et al.: Anal. BIoanal. Chem., 405, 3899 (2013); Vinarta, S.C., et al.: Carb. Poly., 92, 1107 (2013); Kaumanu, M.L., et al.: Soil. Biol. Biochem., 57, 644 (2013); Hailu, T., et al.: Anal. Biochem., 434, 181 (2013);<br></p>

<p>Applications 2-Hydroxyethyl Nortadalafil-d4 is the isotope labelled analog of 2-Hydroxyethyl Nortadalafil (H942245); a derivative of Tadalafil (T004500) which is a compound used for the treatment of erectile dysfunction. Also a phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003); Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005); Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)<br></p>

<p>Applications N2-Methyl Trimethoprim-D3 is a labelled analogue of N2-Methyl Trimethoprim (M331190).<br></p>

<p>Applications Phenol-2,4,6-d3,OD (CAS# 80441-87-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl β-Alanine-2,2,3,3-d4 Ester is an intermediate used in the synthesis of N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine-d4 (C424342), which is an isotope labelled N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine is a metabolite of Tianeptine (T436800), a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br>References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991), Nair, M. et al.: Analyst, 123, 2267 (1998)<br></p>

<p>Applications L-Lysine-DL-amphetamine-d6 2HCl (propane-1,1,2,3,3,3-d6) (CAS# 1276056-89-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-4-Hydroxyphenyl-3,5-d2-alanine (CAS# 30811-19-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled major (toxic) metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)<br></p>

<p>Applications DL-Homocysteine Thiolactone-3,3,4,4-d4 HCl (CAS# 1219805-31-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-Epichlorohydrin-2-d1 (CAS# 70735-27-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopropyl-2,2,3,3-d4-methyl-d2 Alcohol (CAS# 1219805-67-0) is a useful isotopically labeled research compound.<br></p>