Deuterated Compounds

Applications Diethyl 3,7-Bis(formyloxy)-25-methyl-cholestane-26,27-dioic Acid Ester-d3 is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.
References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)

Applications (±)-Prasugrel-d3 (acetate-d3) (CAS# 1127253-02-4) is a useful isotopically labeled research compound. This compound can be used for treating percutaneous coronary intervention.
References Czarnik, A., U.S. Pat. Appl. Publ., 9,(2009);

Applications Propineb-d3 is the labeled analog of Propineb (P771450), which is used as a fungicide.
References Sharma, I.M., et. al.: J. Mycology Plant Pathology, 44, 92 (2014); Gupta, R.C., et. al.: Pestology, 37, 43 (2013)

Applications N,N,N'-Trimethyl-d6-1,3-propanediamine (N,N-dimethyl-d6) (CAS# 1219803-54-9) is a useful isotopically labeled research compound.

Applications N-Methylaniline-2,3,4,5,6-d5 is the deuterated form of N-Methylaniline (M288205). N-Methylaniline is used as an additive in gasoline because of its antiknock properties.
References Liu, Li-jun, et al.: Huaxue Shiji, 37(1), 53-55, 96 (2015); Qin, Li-xia, et al.: Guangzhou Huagong, 43(8), 138-139, 148 (2015);

Applications Tri-n-butyl-d27-amine (CAS# 1219805-78-3) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications Isovaleryl L-Carnitine-d9 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.
References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)

Applications Bis(4-cyanophenyl)methanol-d4 is labelled Bis(4-cyanophenyl)methanol (B422852) which is a metabolite of Letrozole (L330100), a nonsteroidal aromatase inhibitor structurally related to Fadrozole.
References Bhatnagar, A.S., et al: J. Steroid Biochem. Mol. Biol., 37, 1021 (1990), Pfister, C.U., et al.: J. Pharm. Sci., 83, 520 (1994), Lipton, A., et al.: Cancer, 75, 2132 (1995)

Applications Decanoyl-10,10,10,d3-L-carnitine Chloride is the isotope labelled analog of Decanoyl-L-carnitine Chloride (D212580); a metabolite of L-Carnitine (C184110) which is an essential cofactor of fatty acid metabolism. Also required for the transport of fatty acids through the inner mitochondrial membrane.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)