Nicotine and Nicotine Derivatives

<p>Applications A metabolite of Nicotine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-(4-Formylaminobutyryl)pyridine (cas# 887355-56-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007), Roy, K., et al.: Eur. J. Med. Chem., 44, 1941 (2009),<br></p>

<p>Applications Trigonelline (chloride) is an alkaloid found in plants and coffee. Trigonelline is a product of niacin metabolism that is excreted in urine.<br></p>

<p>Stability Hygroscopic<br>Applications A major metabolite of Nicotine in humans. Carcinogen.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),<br></p>

<p>Applications Isotope labelled Nicotelline is a Nicotine (N412420) related metabolite with potential as an inhibitor of human cytochrome P-450 2A6.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Denton, T. et al.: Biochem. Pharm., 67, 751 (2004); Gorrod, J. et al.: Anal. Det. Nic. Rel. Comp. Metab., 69, (1999);<br></p>

<p>Impurity Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine)<br>Stability Light Sensitive<br>Applications (RS)-Nornicotine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).<br>References Hecht, S., et al.: Carcinogenesis, 9, 875 (1988), Rivenson, A., et al.: Cancer Res., 48, 6912 (1988), Hoffmann, D., et al.: Chem. Res. Toxicol., 14, 767 (2001), Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),<br></p>

<p>Applications (S)-Anabasine is a nicotinic receptor agonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Keeler, R., et al.: Clin. Toxicol., 12, 49 (1978); Aceto, M., et al.: J. Med. Chem., 22, 17 (1979); Brand, J., et al.: J. Chem. Ecol., 19, 1315 (1993)<br></p>

<p>Applications N-Methylnicotinamide is a metabolite of Nicotinamide (N407750), which is a water-soluble vitamin B, incorporated within nicotinamide cofactors such as NADH and NADPH. N-Methylnicotinamide is commonly found in the human urine and is used as a biomarker to study diseases such as liver cirrhosis and type 2 diabetes.<br>References Pumpo, R., et al.: Am. J. Gastroenterol., 96, 1183 (2001); Sharma, M., et al.: J. Chem. Pharm. Res., 2, 416 (2010); Al-Nadaf, A., et al.: Bioorg. Medi. Chem., 18, 3088 (2010); Connor, S., et al.: Mol. Biosyst., 6, 909 (2010);<br></p>

<p>Applications rac-Nicotine-d3 N-β-D-Glucuronide is a labelled racemic analogue of Nicotine N-β-D-Glucuronide (N424575), a Nicotine (N412420) metabolite in rat brain. Nicotine N-β-D-Glucuronide is used as a Nicotine biomarker in rat brain.<br>References Alexandrov, K., et al.: Toxicol. Lett., 198, 63 (2010), Huang, L., et al.: J. Neurochem., 109, 826 (2009), Quik, M., et al.: Biochem. Pharmacol., 78, 677 (2009), Weems, J., et al.: Chem. Res. Toxicol., 23, 696 (2010),<br></p>

<p>Applications o-Nicotine is a Nicotine analog (N412420). o-Nicotine has high affinity for nicotinic receptor, and its ability to elicit neurotransmitter secretions make it a good candidate for treating cholinergic neurodegenerative diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Romano, C., et al.: Psychopharmacol., 74, 310 (1981), Wang, D., et al.: Drug Dev. Res., 45, 10 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications S-(-)-Cotinine is a major metabolite of Nicotine (N412450) in humans. It is a carcinogen.This compound is a contaminant of emerging concern (CECs)<br>References Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986); Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996)<br></p>

<p>Applications Nicotelline is a Nicotine (N412420) related metabolite with potential as an inhibitor of human cytochrome P-450 2A6.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Denton, T. et al.: Biochem. Pharm., 67, 751 (2004); Gorrod, J. et al.: Anal. Det. Nic. Rel. Comp. Metab., 69, (1999);<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of (+/-)-Cotinine.<br>References Morselli, P.L., et al.: J. Med. Chem., 10, 1033 (1967),<br></p>

<p>Applications Labelled Isonicotinic Acid (I821760). Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>