Organic Halides

<p>Applications 4-Chloro-4'-hydroxybiphenyl (cas# 28034-99-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications (2,4-difluorophenyl)hydrazine is a reactant in the preparation of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.<br>References Han, S., et. al.: Bioorg. Med. Chem. Lett., 25, 322 (2015)<br></p>

<p>Applications Methyl 5-Chloro-2-[(4-ethoxy-4-oxobutyl)amino]benzoate is a reactant in the synthesis of 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepin, an intermediate in synthesis of Tolvaptan (T536650).<br>References Liu, Dengke, et al.: Tianjin Institute of Pharmaceutical Research, CN 103012265 A 20130403(2013);<br></p>

<p>Applications (1S)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases.<br>References Boehm, M., et al.: PCT Int. Appl., WO 2012158550 A2 20121122 (2012)<br></p>

<p>Applications 4,5-Dichloro-2-nitroaniline<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Methyl 6-Chloronicotinate is used in the determination of Acetamiprid (A150800) and its metabolites in crop and soil.<br>References Tokieda, M., et al.: Nippon Noyaku Gakkaishi, 24, 115 (1999)<br></p>

<p>Applications 1-Bromo-4-chloro-2-nitrobenzene is used in the synthesis of diindolocarbazoles used in the synthesis of ladder oligo(p-aniline)s useful in organic electronics. Also used in the synthesis of novel benzenesulfonamides for the discovery of potent cell cycle inhibitors.<br>References Wakim, S. et al.: Org. Lett., 6, 3413 (2004); Owa, T. et al.: Bioorg. Med. Chem. Lett., 10, 1223 (2000);<br></p>

<p>Applications (3α,5β,7α)-24-Iodo-cholane-3,7-diol Diformate is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.<br>References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)<br></p>

<p>Applications Methyl 3-chlorosulfonylthiophene-2-carboxylate<br></p>

<p>Stability Moisture Sensitive, reacts with Moisture in the air<br>Applications 1,3-Benzodioxole-5-carbonyl chloride (cas# 25054-53-9) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications α-Bromopropiophenone (cas# 2114-00-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-​(Chloromethyl)​allyl-​trimethylsilane is one of the reagents to synthesize Leucasandrolide A Macrolide (I) via Mukaiyama aldol coupling.2-​(Chloromethyl)​allyl-​trimethylsilane was used in catalytic Sakurai reaction of α,​β-​enones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kopecky, D., et al.: J. Am. Chem. Soc., 123, 8420 (2001).Lee, P., et al.: J. Org. Chem., 66, 8646 (2001).<br></p>

<p>Applications 2-Acetoxyisobutyryl Bromide is used as a reagent in the preparation of didehydro-dideoxyinosine phosphoramidate produgs which have anticancer activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Borek, W., et al.: Nucleos. Nucleot. Nucl., 33, 507 (2014)<br></p>