Organic Halides

<p>Applications 4-Chloro-2,5-dimethoxyaniline was an analyte identified in a screening study of electronic nicotine delivery systems (ENDS), which are regulated tobacco products.<br>References Hung, P. H., et al.: J. Applied Toxic., 40, 1566 (2020)<br></p>

<p>Applications Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-binding inhibitor of Eg5 that prevents mitotic progression.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References DeBonis, S. et al.: J. Med. Chem., 51, 1115 (2008); Chadwick, D.J. et al.: J. Chem. Soc. Perk. Trans. Org. Bio-Org. Chem., 1, 102 (1983);<br></p>

<p>Stability Hygroscopic<br>Applications Heptafluorobutyric Acid (HFBA) is used in reversed-phase chromatography.<br> E0<br>References Satake, I., et al.: Biopolymers, 15, 2263 (1976), Aso, K., et al.: Biosci. Biotech. Biochem., 56, 755 (1992), Cecchi, T., et al.: J. Chromatogr., 1216, 1789 (2009),<br></p>

<p>Applications 1-Bromohexane is a very useful synthetic intermediate for pharmaceuticals and organic chemicals. It can be used to react with Mg to prepare Grignard reagents which play an important role in formation of carbon-carbon bond.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tamura, M., et al.: Synth., 6, 303 (1971); Asami, M., et al.: Chem. Lett., 8, 1221 (1985); Akiba, K., et al.: Tetrahedr. Lett., 23, 3935 (1982)<br></p>

<p>Stability Moisture Sensitive<br>Applications n-Undecanoyl Chloride is an analog of Heptanoyl Chloride (H281235), which is used in the synthesis of novel class of 2-Aminopyrimidines as CDK1 and CDK2 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Samanta, R., et al.: Org. Lett., 14, 5518 (2012); Sabbah, M., et al.: Bioorg. Med. Chem., 20, 4727 (2012)<br></p>

<p>Applications N-Phenoxyisopropyl-N-benzylaziridinium Perchlorate is a useful intermediate in the synthesis of aziridinium ions and analogs that functions as α-adrenergic blockades.<br>References Henkel, J. G., et al.: J. Med. Chem., 19, 6 (1976)<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of trifluoroacylated compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References HugenBerg, V., J. Fluorine. Chem., 131, 942 (2010); Belyakova, Z.V., et al.: Russ. J. Gen. Chem., 79, 2634 (2009); Wu, J.L., et al.: Jingxi. Huagong. Zhongjianti., 40, 64 (2010);<br></p>

<p>Applications 1,2,4-Tribromobenzene is a compound commonly used in organic synthesis reactions. 1,2,4-Tribromobenzene is hepatotoxic to rats, and is also toxic to humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dodd, D., et al.: Int. J. Toxicol., 31, 250 (2012); Szymanska, J.: Arch Toxicol., 72, 97 (1998)<br></p>

<p>Applications 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Durban, M. et al.: Eur. J. Lipid. Sci. Tech., 105, 633 (2003);<br></p>

<p>Stability Moisture Sensitive<br>Applications Methyltin Trichloride is used in the synthesis of metallasilesesquiloxanes used for their important application to silica surfaces. Also used in the preparation of organotin(IV) complexes showing antibacterial activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feher, F. et al.: J. Am. Chem. Soc., 114, 3859 (1992); Salam, M., Heteroatom Chem., 24, 43 (2013);<br></p>

<p>Applications A chemical additive to control bacterial contamination in ethanol fermentation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vaisanen, O., et al.: J. Ind. Microbio., 4, 419 (1989), Costerton, J., et al.: J. Bacteriol., 176, 2137 (1994), Pirttijarvi, T., et al.: J. Appl. Bacteriol., 81, 445 (1996),<br></p>

<p>Applications [(2-Bromoethyloxy)methyl]benzene is a reactant used in the preparation of muscarinic antagonist.<br>References Bream, R. et al.: Org. Process. Res. Dev., 17, 641 (2013); Mete, A. et al.: Bioorg. Med. Chem. Lett., 21, 7440 (2011)<br></p>

<p>Applications Octyl Bromide, is a versatile halogenated building block in chemical synthesis. It has also industrial applications. It is used in the preparation of fluorous polymers, which serve as a surface modifier and an emulsifier.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Golling, F. E., et al.: Poly. Prep.(Amer. Chem. Soci. Div. Poly. Chem), 52, 735 (2011);<br></p>

<p>Stability Volatile<br>Applications Perfluorohexane (cas# 355-42-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Chlorobenzenethiol is a reagent used in the synthesis of small-molecule inhibitors of the protein geranylgeranyltransferase Type I (GGTase-I), acting as anti-tumor agents. Also is used in the synthesis of β-sulfanyl carbonyl compounds via Michael addition.<br>References Ranu, B. et al.: Tetrahedron, 60, 4183 (2004); J. Med. Chem., 43, 2310 (2000);<br></p>

<p>Applications Hexadecyltrimethylammonium Bromide (CTAB) is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloro-1,4-phenylenediamine Sulfate<br></p>

<p>Applications Decafluorobiphenyl is used for step−growth polymers synthesis (1).<br>References (1) Deck, P. A. and Maiorana, C. R. Macromolecules 34, 9 (2001)<br></p>

<p>Stability Volatile<br>Applications 1-Chlorobutane is used in biological studies to evaluate the activity of haloalkan dehalogenase from Sphingomonas paucimobilis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oakley, A.J., et al.: Biochem., 41, 4847 (2002)<br></p>

<p>Applications 1,2,4-Triaminobenzene Dihydrochloride is a useful reagent for making multicolor fluorescent carbon dots that can be detected via white-​light-​emitting diodes and water.<br>References Kumari, R., et al.: Langmuir, 36, 5287 (2020)<br></p>

<p>Applications 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone (cas# 99-40-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Tetrachloroethylene is a common industrial solvent that is often found as a contaminant in groundwater. Tetrachloroethylene is also a suspected carcinogen to humans and is difficult to degrade biologically as it has no natural source. This compound is a contaminant of emerging concern (CECs).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fathepure, B. &amp; Boyd, S.: Appl Environ. Microb., 54, 2976 (1988); Ryoo, D., et al.: Nat. Biotech., 18, 775 (2000); Vogel, T. &amp; McCarty, P.: Appl. Environ. Microb., 49, 1080 (1985)<br></p>

<p>Applications 5-Bromo-2-thiophenecarboxaldehyde is used in biological studies as anti-inflammatory and anti-tumor activity of the marine mangrove Rhizophora apiculata.<br>References Prabhu, V.V., et al.: J. Immunotoxicol., 9, 341 (2012);<br></p>

<p>Impurity Phenylephrine EP Impurity A<br>Applications rac Norphenylephrine Hydrochloride is an Impurity A of phenylephrine. A phenylephrine derivative as leukotriene D4 antagonists.<br>References Musser, J.H., et al.: J. Med. Chem., 30, 2087 (1987),<br></p>

<p>Applications Intermediate in the preparation of imidazole antifungal agents.<br>References Albet, C. et al.; J. Pharmaceut. Biomed. 10, 205 (1992); Raga, M. et al.; Eur. J. Med. Chem. 21, 329 (1986)<br></p>

<p>Applications 2-Ethylphenylhydrazine, HCl<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Chlorprothixene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Dihexadecyl(dimethyl)azanium bromide is an ionic olefin derivative used in the preparation of metal-containing ionic liquids for use in particle synthesis and materials with magnetic or thermochromic properties.<br>References Zabel, A.; et al.: Int. J. Mol. Sci., 17, 596/1 (2016).<br></p>

<p>Applications 1,2,4-Trichlorobenzene is a solvent in various organic chemical reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Legrand, Y. et al.: J. Am. Chem. Soc., 125, 15789 (2003); Aver'yanov, V. et al.: Kin. Cata., 43,175 (2002);<br></p>

<p>Applications (R,R)-Ethambutol Dihydrochloride shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800), an antibacterial (tuberculostatic).<br>References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962), Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971), Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)<br></p>

<p>Applications (3,3,3-Trifluoropropyl)methyldichlorosilane, can be used in synthesis of Methyl(3,3,3-trifluoropropyl)silanediol (M327230), that functions in combination with other related substances like crospovidone for eliminating biological harmful substances from bodily fluids.<br> E0<br>References Hajek, M., et al.: Ger. Offen. (2011), DE 102009037015 A1 20110217<br></p>

<p>Applications 4,4'-Bis(bromomethyl)-1,1'-biphenyl (cas# 20248-86-6) is a useful research chemical.<br></p>

<p>Stability Unstable in Solution<br>Applications 2-(Trimethylsilyl)ethoxymethyl chloride is mostly used in organic synthesis to protect hydroxyl functionalities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lipshutz, B. &amp; Miller, T.: Tetrahedron Lett., 30, 7149 (1989); Wada, T., et al.: Tetrahedron Lett., 36, 1683 (1995)<br></p>

<p>Applications 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Durban, M. et al.: Eur. J. Lipid. Sci. Tech., 105, 633 (2003);<br></p>

<p>Applications 5-IODO-A-85380 Dihydrochloride is a highly potent and subtype-selective agonist for AChR α4β2 and AChR α6β2.<br>References Koren, A.O., et al.: J. Med. Chem., 41, 3690-3698 (1998); Muhkin, A.G., et al.: Mol. Pharmacol., 57, 642-649 (2000); Mogg, A.J., et al.: Neuropharmacology, 47, 848-859 (2004);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Bromomethylbenzil (cas# 18189-19-0) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications Trichloromethyl chloroformate is used as a reagent to prepare diisocyanates (e.g. Tolylene 2,4-Diisocyanate [T536710]) with benzene or Furan (F863650) rings. Trichloromethyl chloroformate is also used as a dehydrating agent in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mai, K. &amp; Patil, G.: Tetrahedron Lett., 27, 2203 (1986); Nowakowski, J.: Prak. Chem.-Chem. Ztg., 334, 187 (1992)<br></p>

<p>Applications 1-Chloropentane is used for studies on the antimicrobial activity of some halogenated hydrocarbons and their derivatives, effect of chlorinated hydrocarbons on the myelin sheath of peripheral nerve tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kalatskaya, L. M., et al.: Fiziologicheski Aktivnye Veshchestva; 20, 77 (1988); Rumsby, M. G., et al.: J. Neurochem., 13, 1513 (1966)<br></p>

<p>Impurity Isoconazole Impurity 6<br>Applications α-(Chloromethyl)-2,4-dichlorobenzyl alcohol is used in the synthesis of monocyclic nitroimidazole analogs of econazole. Isoconazole Impurity 6.<br>References Lee, S., et al.: Bioorg. Med. Chem. Lett., 21, 1515 (2011);<br></p>

<p>Applications An intermediate for the preparation of Citalopram.<br></p>

<p>Stability Moisture Sensitive<br>Applications Pentachloroacetone is a disinfection byproduct.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jeong, C., et al.: Environ. Sci. Technol., 46, 12120 (2012); Colman, J., et al.: Toxicol. Appl. Pharm., 254, 100 (2011)<br></p>

<p>Applications 3-Bromobenzyl bromide<br></p>

<p>Applications 2-Chlorobenzonitrile is an activated aryl chloride that is commonly used in reactions that involve the Palladium-catalyzed direct arylation of heteroaromatics (e.g. 3-aminopicolinic acid [A627800]). 2-Chlorobenzonitrile and its substituted derivatives (e.g. 2,3-dichloro-6-nitrobenzonitrile [2112-22-3]) also have potential anti-inflammatory properties.<br>References Andreu, M., et al.: Chem. Commun., 24, 2475 (2000); Hellman, W., et al.: J. Med. Chem., 21, 906 (1978); Roy, D., et al.: ACS Catal., 2, 1033 (2012);<br></p>

<p>Applications 12-Chlorododecanoic Acid is used via animation to synthesize α-Amino dodecanoic acid (ADA); Also, it is derived from 12-Hydroxylauric Acid (H943775), which is used in the structural and functional characterization of S-nitrosoglutathione reductase from Solanum lycopersicum.<br>References Shi, X., et al.: Jingxi Huagong, 30, 911-914 (2013); Kubienova, L., et. al.: Biochimie, 95, 889 (2013)<br></p>

<p>Applications (6-​Amino-​2,​3-​dichlorobenzyl)​amine is a reagent used in the synthesis of 3-Hydroxyanagrelide a derivative of Anagrelide (A637300), a drug used in the treatment of thrombocythemia.<br>References Scott, R. et al.: Heterocycles, 86, 1637 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications 4,4'-Oxybis[p-(phenylsulfonylaniline)] Hydrochloride is used in the preparation of polyamido polysulfone thermoplastics.<br>References Cho, I., et al.: U.S. (1975), US 3859252 A 19750107<br></p>

<p>Applications 1-chlorohexan-2-one (cas# 20261-68-1) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Lauroyl Chloride (cas# 112-16-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(4-Octylphenyl)-1-iodoethane (cas# 162358-07-8) is a compound useful in organic synthesis.<br></p>