Organic Halides

Stability Store FROZEN
Applications Material that was assayed to be approximately 80% pure was diluted to 5% in benzene.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3-Chloro-5-Hydroxy-2-pentanone is used to prepare thiothiamine.
References Li, L. et al.: Faming Zhuanli Shenqing (2014), CN 104140420 A

Stability Hygroscopic
Applications 3-(Dimethylamino)propionic Acid Hydrochloride is a useful reagent for the preparation of biological active small molecules.
References Salado, I. G., et al.: J. Med. Chem., 57, 2755 (2014)

Applications Tetrakis(acetonitrile)palladium Bis(tetrafluoroborate) is used to prepare an α-Diimine-transition metal complex, which is used as a catalyst for polymerization of olefins. It is also a catalyst used in cross coupling reaction for C-C, C-O, and C-N bond formation.
References Feldman, J., et al.: Organometallics, 16, 1514 (1997); Johnson, L., et al.: PCT Int. Appl., WO 9623010 A2 19960801 (1996); Poppenbery, J., et al.: Surface Sci., 2011; Pijnenburg, N., et al.: Dalton Transactions, 40, 8896 (2011); Kilpin, K., et al.: Inorg. Chem., 50, 6334 (2011)

Applications 4-Aminoresorcinol Hydrochloride is a reactant in the preparation of diethers with antiviral activity against group A and B human Rhinoviruses.
References Bernard, A.M., et. al.: Bioorg. Med. Chem., 22, 4061 (2014)

Stability Extremely moisture sensitive
Applications Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bannwarth,W. & Kung, E.: Tetrahedron Lett., 30, 4219 (1989)

Applications (4-Isopropoxyphenyl)hydrazine hydrochloride (cas# 104033-62-7) is a useful research chemical.

Applications 4-Chlorobenzyl bromide

Applications (R)-(+)-2-Chloropropionic Acid (cas# 7474-05-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2,5-Difluorophenylacetic acid has been used in the synthesis of 2,2-dimethyl-4-(2,5-difluorophenyl)-5-[4-(aminosulfonyl)phenyl]-3(2H)-furanone.
References Chin, O., et al.: J. Pharm., 44, 138 (2013)

Applications 2,6-Dichloro-4-nitroanisole (cas# 17742-69-7) is a useful research chemical.

Applications 3-Chlorobenzyl chloride (cas# 620-20-2) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3-Phenoxypropyl Bromide is a reagent used in the synthesis of damidines in the study of myotonic dystrophy. Also used in thepreparation pf phenoxyalkylbenzimidazoles with antitubercular activity.
References Siboni, R. et al.: J. Med. Chem., 58, 5770 (2015); Chandrasekera, N. S. et al.: J. Med. Chem., 58, 7273 (2015);

Applications 3-Chloro-4-fluorobenzotrifluoride acts as a reagent in the synthesis of β-substituted 3-(4-aryloxyaryl)propanoic acid as GPR40 agonists.
References Walsh, S. P., et al.: Bioorg. Med. Chem. Lett., 21, 3390 (2011)

Stability Hygroscopic
Applications 5-Chloro-2-Thiophenecarbonyl Chloride is a reagent in the synthesis of indolinyl-thiazole based inhibitors of cellular lipid uptake. Also used in the preparation of anticoagulants and such related promising drug candidates.
References Dockendorff, C. et al.: ACS Med. Chem. Lett.., 6, 375 (2015);

Impurity Fluorouracil EP Impurity E
Applications Used for the experimental and clinical treatment of neoplastic and viral diseases. Fluorouracil EP Impurity E.
References Yu, H., et al.: J. Biol. Chem., 268, 15935 (1993), Staleva, L., et al.: Mutat. Res., 370, 81(1996), Harris, V., et al.: J. Mol. Biol., 326, 1389 (2003)

Applications 3-Bromo-4-isopropylbenzoic acid

Applications N-(4-Chlorophenyl)-2,6-Difluorobenzamide (cas# 122987-01-3) is a useful research chemical.

Stability Hygroscopic
Applications (2R)-Tetrahydro-2-furanmethanamine is a stereoisomer of Tetrahydro-2-furanmethanamine (T293545) which is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Tetrahydro-2-furanmethanamine (T293545) is also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors.
References Lopez-Rodriguez, M. et al.: 44, 4504 (2001); Liu, G. et al.: J. Med. Chem., 50, 3086 (2007);

Applications Reagent used in the preparation of cyclopropane derivatives.
References Antipenko, L., et al.: Chem. Pharm. Bull., 57, 580 (2009), Kumar, A., et al.: Bioorg. Med. Chem., 17, 5285 (2009),

Applications 2-Bromoethyl Methyl Ether was used as a reactant for the preparation of alkyl ethers of β-alkylcholine salts.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Major, R.T., Cline, J.K.: J. Am. Chem. Soc., 55, 2504 (1933)

Applications 1-BROMODOCOSANE (cas# 6938-66-5) is a useful research chemical.

Applications Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.

Applications 3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-diethylpropan-1-amine Hydrochloride (E/Z Mixture) is an intermediate in synthesizing N-Diethylnordoxepin Salt (D468115), a compound useful in organic synthesis.

Applications 3-Bromo-1-(2-octylphenyl)propan-1-one is a chemical useful in organic synthesis.

Applications 4,4-diethylcyclohexan-1-amine hydrochloride (cas# 1087747-58-7) is a useful research chemical.

Applications 3,5-Dichloro-4-Hydroxybenzenesulfonic Acid (cas# 25319-98-6) is a useful research chemical.

Applications 2-[(Benzyloxycarbonyl)amino]-4,4,4-trifluorobutanoic acid is used in the preparation of benzamides and nicotinamides as spleen tyrosine kinase inhibitors.
References Jia, Z., et al.: PCT Int. Appl., 359 (2012)

Applications 4-Chloro-5-(2,3-dichlorophenoxy)-1,2-benzenediamine is an intermediate in the synthesis of 5-Chloro-6-(2,3-dichlorophenoxy)-1,3-dihydro-2H-benzimidazol-2-one (C365505), which is a metabolite of Triclabendazole (T774175), the only anthelmintic drug, which is active against immature, mature and adult stages of fluke.
References Whelan, M., et al.: J. Chromato., 1275, 41 (2013); Barrera, S., et al.; Antimicrob. Agent. Chemother., 56, 3535 (2012);

Applications Ethyl 8-bromooctanoate is a useful research reagent for organic synthesis and other chemical processes.
References Shao, M., et al.: Bioorg. Med. Chem. Lett., 27, 4051 (2017); Wang, L., et al.: Chin. J. Chem., 32, 157 (2014)

Applications 2-Amino-4-chlorobenzenethiol is used as reagent in the synthesis of several organic compounds including that of MHY908 which is an inhibitor of melanogenesis and can potentially be used in the prevention and treatment of pigmentation disorders. Also used in the synthesis of γ-lactam analogs of prostaglandin E2 which may act as EP4 agonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Park, M., et al.: Arch. Pharm. Res., 38, 505 (2015); Kambe, T., et al.: Bioorgan. Med. Chem., 20, 3502 (2012);