Organic Halides

<p>Applications m-Toluoyl Chloride is used as a reagent in the synthesis of glycine benzamides as oral GPR139 receptor agonists. m-Toluoyl Chloride is also used in the preparation of colchicine derivatives which have potent anticancer activity and reduced P-glycoprotein induction liability.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dvorak, C.A., et al.: ACS Med. Chem. Lett., 6, 1015 (2015); Singh, B., et al.: Org. Biomol. Chem., 13, 5674 (2015)<br></p>

<p>Applications 2,3,4-Trichloronitrobenzene is a useful synthetic intermediate that is mainly used as the starting material in the synthesis of third generation quinolone antibacterial drugs, such as Lomefloxacin (L469415, HCl) and Ofloxacin (O245750). 2,3,4-Trichloronitrobenzene is also used as the starting material in the synthesis of Aclonifen (A190200); a compound used as a pesticide and herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, Y., et al.: Guangdong Huagong, 36, 20 (2009); Laini, A., et al.: Sci. Total Environ., 438, 312 (2012); Fantke, P., et al.: Enviorn. Int., 49, 9 (2012)<br></p>

<p>Applications 2-Amino-3-chloro-1,4-benzenedicarboxylic Acid 1,4-Dimethyl Ester is a ueful synthetic interemediate.<br></p>

<p>Applications 2-Bromo-4-(ethoxycarbonylthio)-4-thiobenzoic Acid (cas# 1076199-58-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Used for preparation of [[(triazolylmethyl)pyridyl]phenyl]tetrazoles and related compounds as cardiovascular agents.<br>References Behforouz, M., et al.: J. Med. Chem., 46, 5773 (2003), Behforouz, M., et al.: Bioorg. Med. Chem., 15, 495 (2007),<br></p>

<p>Applications 1-Bromo-2-chloroethane is a reagent used in the preparation of potent P-glycoprotein inhibitors carrying a polycyclic scaffold.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bisi, A., et al.: J. Med. Chem, 49, 3049 (2006);<br></p>

<p>Applications 2,​2,​2-​Trifluoro-​N-​[(1R,​4S)​-​4-​(hydroxymethyl)​-​2-​cyclopenten-​1-​yl]​-​acetamide is an intermediate in synthesizing N6-Cyclopropyl-9-[(1R,4S)-4-[(1,1-dimethylethoxy)methyl]-2-cyclopenten-1-yl]-9H-purine-2,6-diamine (Abacavir EP Impurity F) (C989915), an impurity of Abacavir (A104990), a guanosine analog that inhibits reverse transcriptase (NRTI) (1,2).<br></p>

<p>Applications 1,1'-Oxybis[2-chloro-ethane] is a carcinogen. It is an intermediate used to prepare 2,2'-[Oxybis(2,1-ethanediylimino)]bis-ethanol which is patented as one of the antibacterial oral compositions in mouthwash.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Norpoth, K., et al.: J. Cancer Res. Clin. Oncol., 112, 125 (1986); Weisburger, E., et al.: J. Nat. Cancer. Inst., 67, 75 (1981); Gaffar, A., et al.: U.S. (1980), US 4224309 A 19800923.<br></p>

<p>Applications 3-Chlorobenzoyl Chloride is used in the synthesis of isoquinoline derivatives as potent CRTH2 antagonists in treatment of allergies. Also used in the synthesis of anticancer 2-phenzainamine derivatives.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishikawa-Shimono, R. et al.: Bioorg. Med. Chem., 21, 7674 (2013); Gao, X. et al.: Eur. J. Med. CHem., 69, 1 (2013);<br></p>

<p>Applications Cyclohexanecarbonyl Chloride is used to prepare 1,2,3-triazoles as inhibitors of human immunodeficiency virus type 1 protease. It was also used to synthesize benzothiazole as potent antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Whiting, M., et al.: J. Med. Chem., 49, 7697 (2006); Yoshida, M., et al.: Bioorg. Med. Chem. Lett., 15, 3328 (2005)<br></p>

<p>Applications 3-Chlorophenylboronic acid is a useful research chemical, a useful reagent for Suzuki-Miyaura cross-coupling reactions.<br>References Savitha, B., et al.: J. Heterocycl. Chem., 55, 2277 (2018); Liu, K., et al.: Eur. J. Org. Chem., 34, 4769 (2018)<br></p>

<p>Applications N-(6-Bromohexyl)Phthalimide (cas# 24566-79-8) is a useful research chemical.<br></p>

<p>Applications 2-(Iodomethyl)-6-[(phenylmethoxy)methyl]-1,4-dioxane is used in the preparation of cyclic oligoglycerols as standards.<br>References Nemoto, H., et al.: J. Med. Chem., 38, 1673 (1995), Koerner, T., et al.: Carbohydr. Res., 59, 403 (1977),<br></p>

<p>Applications 2,4,6-Trimethyliodobenzene (cas# 4028-63-1) is a useful research chemical.<br></p>

<p>Applications Acetamidine Hydrochloride (cas# 124-42-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2,3-Trichlorobenzene is an isomer of 1,2,4-Trichlorobenzene which is a solvent in various organic chemical reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Legrand, Y. et al.: J. Am. Chem. Soc., 125, 15789 (2003); Aver'yanov, V. et al.: Kin. Cata., 43,175 (2002);<br></p>

<p>Applications 3-Bromo-2-hydroxybenzoic Acid is a potential an intermediate formed in the synthesis of 3-[4-(2-Pyridylsulfamoyl)phenyl] Sulfasalazine (P995810), an impurity of Sulfasalazine (S699084), an anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.<br>References Schroder, H., et al.: Clin. Pharmacol. Ther.,13, 539 (1972); McDonnell, J.P., et al.: Anal. Profiles Drug Subs., 5, 515 (1976); Klotz, U., et al.: Clin. Pharmacokinet.,10, 285 (1985)<br></p>

<p>Applications α-Chlorophenylacetyl Chloride is a reagent used for dehydrohalogenation of ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brady, W.T., et al.: J. Org. Chem., 45, 3525 (1980); Brady, W.T., et al.: J. Org. Chem., 45, 2025 (1980);<br></p>

<p>Stability Moisture Sensitive<br>Applications Cyclopropanecarbonyl Chloride is a reagent used in the synthesis of orally bioavailable HCV NS5A inhibitor for the treatment of Hepatitis C virus.<br>References Kang, IJ. Med. Chem., 60, 228 (2017);<br></p>

<p>Applications ISOPROPYL TRIFLUOROACETATE (cas# 400-38-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>